Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models

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Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...743874H
P356DOI10.1371/JOURNAL.PONE.0043874
P932PMC publication ID3427312
P698PubMed publication ID22937115
P5875ResearchGate publication ID230769846

P2093author name stringTian Lan
Xiaoyan Shen
Juan Huang
Peiqing Liu
Jing Peng
Heqing Huang
Weihua Liu
Kaipeng Huang
Shaogui Wang
Xi Xie
P2860cites workThe S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes.Q53424335
Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptorQ28262554
Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathwayQ28573256
Sphingosine-1-phosphate: an enigmatic signalling lipidQ29620563
Platelet-released phospholipids link haemostasis and angiogenesisQ31882372
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient miceQ34245331
An update on sphingosine-1-phosphate and other sphingolipid mediatorsQ34402916
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsQ34552498
Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucoseQ34777983
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cellsQ35595685
Biologically active sphingolipids in cancer pathogenesis and treatmentQ35852313
Pathogenetic mechanisms of diabetic nephropathyQ36153062
Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseasesQ36393610
Diabetic nephropathy: from mechanisms to rational therapies.Q36541571
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphateQ36797828
Autocrine and paracrine roles of sphingosine-1-phosphateQ36955411
A glimpse of various pathogenetic mechanisms of diabetic nephropathyQ36979205
Dissecting the role of the S1P/S1PR axis in health and disease.Q37830235
Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy.Q37871339
TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signalingQ39634008
Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cellsQ40429151
Connective tissue growth factor (CTGF) promotes activated mesangial cell survival via up-regulation of mitogen-activated protein kinase phosphatase-1 (MKP-1).Q41824997
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose conditionQ42720652
Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathwayQ42963879
Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injuryQ43071829
Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cellsQ43935598
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptorsQ44578313
Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy.Q46100345
Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progressionQ46156477
Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose conditionQ46163975
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectdiabetic nephropathyQ1129105
P304page(s)e43874
P577publication date2012-08-24
P1433published inPLOS OneQ564954
P1476titleBerberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models
P478volume7

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cites work (P2860)
Q50089534Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway
Q51243597Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text].
Q39208146Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats
Q52586128Cell Adhesion Molecules are Mediated by Photobiomodulation at 660 nm in Diabetic Wounded Fibroblast Cells.
Q49858961Chinese medicine for diabetic kidney disease in China
Q36119717Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries
Q34081401Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells
Q28115790Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression
Q92619096Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease by regulating the p38 MAPK signaling pathway
Q90219783Lipid mediators of insulin signaling in diabetic kidney disease
Q92853737Lysophosphatidic Acid Signaling in Diabetic Nephropathy
Q40704553Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Q38879580Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation
Q37210162Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice
Q89582740Renoprotective effects of Gushen Jiedu capsule on diabetic nephropathy in rats
Q38217707Research progress in signalling pathway in diabetic nephropathy
Q92510491Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review
Q37675523Sphingosine-1-phosphate acts as a key molecule in the direct mediation of renal fibrosis.
Q53070283Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor.
Q47945057The role and mechanism of glutamic NMDA receptor in the mechanical hyperalgesia in diabetic rats.
Q94950021Therapeutic Application of Nutraceuticals in Diabetic Nephropathy: Current Evidence and Future Implications
Q34256862Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats

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