Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression

scientific article published on 4 June 2013

Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/JMF.2012.0175
P932PMC publication ID3684211
P698PubMed publication ID23734997
P5875ResearchGate publication ID237055188

P50authorVanja Vasiljev MarchesiQ62633229
Hrvoje JakovacQ62633232
P2093author name stringRobert Domitrović
Biljana Blažeković
P2860cites workThe role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachlorideQ23919498
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TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.Q39407549
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G proteinQ41097795
Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expressionQ41674065
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Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated miceQ42795444
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in miceQ43108235
Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysisQ43649929
Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liverQ44204335
Coptidis Rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active componentsQ44852668
Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects.Q45052402
Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.Q45964167
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Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice.Q53163497
Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea.Q53515180
TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells.Q54568076
Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesisQ70971793
Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the ratQ74136816
Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the ratQ77078692
Immunopathogenesis of hepatic fibrosis in chronic liver injury induced by repeatedly administered concanavalin AQ78177107
Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosisQ82604112
P433issue6
P921main subjectintoxicationQ18621601
P304page(s)518-528
P577publication date2013-06-04
P1433published inJournal of Medicinal FoodQ15759825
P1476titleResolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression
P478volume16

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cites work (P2860)
Q38588143A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives
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Q64914137Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice.
Q33819605Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities
Q47450466Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis
Q37718578Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging
Q38220772Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives
Q34551170Hepatoprotective and antioxidant activities of extracts from Salvia-Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice
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Q30374500Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.
Q34017968Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis
Q37210162Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice
Q41505591Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice
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Q64229967Salvianolic Acids: Potential Source of Natural Drugs for the Treatment of Fibrosis Disease and Cancer
Q26770933Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

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