| scholarly article | Q13442814 |
| P50 | author | Lauren M Aleksunes | Q59690593 |
| P2093 | author name string | Curtis D Klaassen | |
| Juergen Thomale | |||
| Michael J Goedken | |||
| Jose E Manautou | |||
| Cheryl E Rockwell | |||
| P2860 | cites work | Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 |
| Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers | Q24643974 | ||
| Identification of platform-independent gene expression markers of cisplatin nephrotoxicity | Q24811646 | ||
| Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway | Q28238852 | ||
| Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element | Q28240487 | ||
| The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity | Q28296400 | ||
| Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology | Q28377171 | ||
| Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic | Q28580384 | ||
| Multidrug resistance associated protein 2 mediates transport of prostaglandin E2 | Q28580790 | ||
| Transcription factor-kappa B (NF-kappa B) and renal disease. | Q34135831 | ||
| Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter | Q34278223 | ||
| Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury | Q34572978 | ||
| Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. | Q34604202 | ||
| The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs | Q35234371 | ||
| Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease | Q36846919 | ||
| Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment | Q36944317 | ||
| Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. | Q36971772 | ||
| Cisplatin nephrotoxicity: mechanisms and renoprotective strategies | Q37084089 | ||
| Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity | Q37353430 | ||
| Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice | Q38340562 | ||
| Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells | Q39812532 | ||
| Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells | Q39973157 | ||
| The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta | Q40200280 | ||
| Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene | Q40327011 | ||
| The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling | Q40414479 | ||
| Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines. | Q41518542 | ||
| Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. | Q41648408 | ||
| Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide | Q42155559 | ||
| Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin | Q42162315 | ||
| Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice | Q42165757 | ||
| CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes | Q43130338 | ||
| Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei | Q43157204 | ||
| Nrf2-deficient female mice develop lupus-like autoimmune nephritis | Q43750335 | ||
| EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice | Q44426584 | ||
| A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate | Q44987535 | ||
| Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells | Q45249189 | ||
| Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. | Q46193503 | ||
| Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer | Q46587567 | ||
| Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells | Q47968983 | ||
| The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats | Q68159953 | ||
| The role of prostaglandins in early polyuria induced by cisplatin in the rat | Q69079752 | ||
| Intracellular metabolites of cisplatin in the rat kidney | Q69627145 | ||
| Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance | Q72932284 | ||
| Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice | Q77073068 | ||
| MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions | Q94705291 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2-12 | |
| P577 | publication date | 2010-07-06 | |
| P1433 | published in | Journal of Pharmacology and Experimental Therapeutics | Q1500272 |
| P1476 | title | Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity | |
| P478 | volume | 335 |
| Q38180565 | A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity |
| Q36463474 | Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor |
| Q37219376 | Aging increases the susceptibility of cisplatin-induced nephrotoxicity |
| Q42517747 | Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice |
| Q46453487 | Ameliorative effect of an oxovanadium (IV) complex against oxidative stress and nephrotoxicity induced by cisplatin. |
| Q38038498 | An overview of transcriptional regulation in response to toxicological insult. |
| Q43475358 | Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects |
| Q46448963 | Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice |
| Q34473644 | Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway |
| Q28546838 | Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways |
| Q50198506 | Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study |
| Q34979691 | Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1. |
| Q34415403 | Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties |
| Q45926436 | Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity. |
| Q30614574 | Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. |
| Q41879656 | Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo |
| Q38807055 | CDDO and Its Role in Chronic Diseases. |
| Q37978306 | Comparative nephrotoxicity of Cisplatin and nedaplatin: mechanisms and histopathological characteristics |
| Q46654417 | Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress |
| Q47617733 | Danshen modulates Nrf2-mediated signaling pathway in cisplatin-induced renal injury |
| Q43679311 | Diabetic nephropathy: Could problems with bardoxolone methyl have been predicted? |
| Q34441024 | Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling |
| Q28078928 | Emerging roles of Nrf2 signal in non-small cell lung cancer |
| Q59202699 | Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats |
| Q47739726 | Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus |
| Q42141815 | Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy |
| Q36364169 | Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney |
| Q91635364 | Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway |
| Q90703196 | Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways |
| Q41645053 | Keap1 hypomorphism protects against ischemic and obstructive kidney disease |
| Q37233557 | Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer |
| Q34289003 | NRF2 and cancer: the good, the bad and the importance of context. |
| Q38167610 | Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. |
| Q24632281 | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress |
| Q41679697 | Nrf2 activators as potential modulators of injury in human kidney cells |
| Q36991534 | Nrf2: a potential target for new therapeutics in liver disease |
| Q33849235 | PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells |
| Q36412220 | Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin. |
| Q40600080 | Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin. |
| Q37210162 | Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice |
| Q47215463 | Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice. |
| Q37479069 | Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice |
| Q54978951 | Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity. |
| Q28390004 | Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules |
| Q36017543 | Renal efflux transporter expression in pregnant mice with Type I diabetes |
| Q94594727 | Renoprotective Effects of a New Free Radical Scavenger, XH-003, against Cisplatin-Induced Nephrotoxicity |
| Q38115682 | Role of Nrf2 in protection against acute kidney injury |
| Q47093575 | Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria |
| Q36293645 | Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. |
| Q37145435 | Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives |
| Q38786854 | Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression |
| Q36788430 | Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease |
| Q38114031 | The Nrf2 pathway in the progression of renal disease |
| Q37616058 | The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice. |
| Q64116359 | The role of nuclear factor erythroid-2-related factor 2 expression in radiocontrast-induced nephropathy |
| Q33716356 | The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease |
| Q42776770 | Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury |
| Q28080723 | TrxR1 as a potent regulator of the Nrf2-Keap1 response system |
| Q52718396 | UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response. |
| Q26778360 | Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress |
| Q28395772 | miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury |
| Q42722024 | xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells |
Search more.