Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

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Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084130870
P356DOI10.1038/S41598-017-00777-6
P932PMC publication ID5429600
P698PubMed publication ID28386062

P50authorAdolfo H MoraesQ58763060
Guilherme A P de OliveiraQ88938539
Jerson LimaQ37838168
Fernando L. PalhanoQ41046195
José Renato PintoQ46720244
P2093author name stringEwa A Bienkiewicz
Guilherme A P de Oliveira
Martha M Sorenson
Mayra de A Marques
Tiago Veltri
P2860cites workTemperature Dependence of Dynamics and Thermodynamics of the Regulatory Domain of Human Cardiac Troponin C†Q57986091
A comparative study of the interactions of synthetic peptides of the skeletal and cardiac troponin I inhibitory region with skeletal and cardiac troponin CQ68000642
The effect of temperature on some calcium-binding properties of troponin C and calmodulinQ71469666
Comparative studies on thermostability of calmodulin, skeletal muscle troponin C and their tryptic fragmentsQ71664056
Optical spectroscopic characterization of single tryptophan mutants of chicken skeletal troponin C: evidence for interdomain interactionQ73046489
Temperature dependence of 1H chemical shifts in proteinsQ73584658
Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac troponin C: evidence for communication with the structural calcium binding sitesQ85318244
Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated formQ24306847
Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-CQ27618840
Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033Q27631341
Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridilQ27639160
The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin IQ27652246
Solution Structure of Human Cardiac Troponin C in Complex with the Green Tea Polyphenol, (-)-Epigallocatechin 3-GallateQ27656100
Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory DomainQ27740365
Calcium-induced structural transition in the regulatory domain of human cardiac troponin CQ27745491
The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift dataQ27860592
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
Calcium plays distinctive structural roles in the N- and C-terminal domains of cardiac troponin CQ28264709
Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?Q28264798
Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin CQ28284750
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin CQ28287686
The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopyQ28293625
Regulation of contraction in striated muscleQ28610114
Implications of protein conformational diversity for binding and development of new biological active compounds.Q30358794
Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.Q30360846
Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.Q30397033
Random coil chemical shifts in acidic 8 M urea: implementation of random coil shift data in NMRViewQ30619296
Characterisation of low free-energy excited states of folded proteins.Q31940086
A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin bindingQ33885078
Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory functionQ34179870
Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.Q34488809
Force and velocity of sarcomere shortening in trabeculae from rat heart. Effects of temperatureQ34563703
A delicate interplay of structure, dynamics, and thermodynamics for function: a high pressure NMR study of outer surface protein A.Q35769962
Thermodynamics of protein destabilization in live cellsQ36155123
The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.Q36201836
An interdomain distance in cardiac troponin C determined by fluorescence spectroscopyQ36281916
Influence of temperature on the calcium sensitivity of the myofilaments of skinned ventricular muscle from the rabbitQ36410193
The effect of altered temperature on Ca2(+)-sensitive force in permeabilized myocardium and skeletal muscle. Evidence for force dependence of thin filament activationQ36434728
Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathyQ36452032
Sarcomeric proteins and inherited cardiomyopathies.Q37023249
A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.Q37254027
Molecular and functional consequences of mutations in the central helix of cardiac troponin C.Q39748609
Circular dichroismQ40400685
The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29QQ40572286
Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.Q40987953
Mutation of the high affinity calcium binding sites in cardiac troponin CQ43479732
Insights into the intramolecular coupling between the N- and C-domains of troponin C derived from high-pressure, fluorescence, nuclear magnetic resonance, and small-angle X-ray scattering studiesQ44811083
Stability and folding studies of the N-domain of troponin C. Evidence for the formation of an intermediate.Q44936399
Proceedings: Effect of temperature on the pCa-tension relation of skinned ventricular muscle of the catQ45078028
Expanding the range of free calcium regulation in biological solutionsQ46804677
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)691
P577publication date2017-04-06
P1433published inScientific ReportsQ2261792
P1476titleAmide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C
P478volume7

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cites work (P2860)
Q47710503Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E).
Q89620094Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants
Q91828823Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hotspots that are associated with worse clinical outcomes
Q58903690Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle
Q90748901The missing links within troponin
Q94560954Thermal Activation of Thin Filaments in Striated Muscle
Q49376239Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction
Q92421071Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

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