| scholarly article | Q13442814 |
| review article | Q7318358 |
| P819 | ADS bibcode | 1999PNAS...96.7680Y |
| P356 | DOI | 10.1073/PNAS.96.14.7680 |
| P932 | PMC publication ID | 33601 |
| P698 | PubMed publication ID | 10393880 |
| P5875 | ResearchGate publication ID | 12905122 |
| P2093 | author name string | T L Yaksh | |
| X Y Hua | |||
| N Nozaki-Taguchi | |||
| M Marsala | |||
| I Kalcheva | |||
| P2860 | cites work | International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes | Q28239501 |
| The NMDA-receptor antagonist CPP abolishes neurogenic 'wind-up pain' after intrathecal administration in humans | Q28243687 | ||
| Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma | Q28512432 | ||
| Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain | Q35953747 | ||
| Intracellular calcium mobilization and neurite outgrowth in mammalian neurons | Q36751532 | ||
| Electrophysiological mechanisms in inflammatory pain | Q37778411 | ||
| Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain | Q39453466 | ||
| Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. | Q39459817 | ||
| Pre-emptive Analgesia: A Systematic Review of Clinical Studies | Q39476283 | ||
| Calcium signaling in neurons: molecular mechanisms and cellular consequences | Q40506441 | ||
| Phase I safety assessment of intrathecal neostigmine methylsulfate in humans | Q40593727 | ||
| Psychophysiology of experimentally induced pain | Q40825822 | ||
| Peptides and the primary afferent nociceptor | Q40911083 | ||
| alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984-1995). | Q41148480 | ||
| A review of intrathecal baclofen in the management of spasticity | Q41473564 | ||
| Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids | Q41613425 | ||
| Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. | Q43708326 | ||
| Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. | Q43774001 | ||
| Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity | Q44125385 | ||
| Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha 2 receptor systems | Q44900399 | ||
| Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. | Q45167806 | ||
| Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. | Q45931253 | ||
| A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat. | Q45943942 | ||
| Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction | Q46008800 | ||
| Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB). | Q46046424 | ||
| Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine | Q46165072 | ||
| Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats | Q46176636 | ||
| Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. | Q46192578 | ||
| Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition | Q46223466 | ||
| Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. | Q46240462 | ||
| The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship | Q46293391 | ||
| Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input | Q46446826 | ||
| Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase | Q46490168 | ||
| The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. | Q46510308 | ||
| Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia | Q46654746 | ||
| Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. | Q46709876 | ||
| Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity | Q46914865 | ||
| Chronic catheterization of the spinal subarachnoid space | Q48344815 | ||
| Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis | Q48509003 | ||
| Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord | Q48617112 | ||
| Role of spinal cyclooxygenase (COX)-2 on thermal hyperalgesia evoked by carageenan injection in the rat. | Q48659701 | ||
| Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons | Q48694926 | ||
| Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites | Q48708894 | ||
| Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats | Q48726569 | ||
| Effects of preemptive or postinjury intrathecal local anesthesia on persistent nociceptive responses in rats. Confounding influences of peripheral inflammation and the general anesthetic regimen. | Q50749894 | ||
| Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats. | Q50766799 | ||
| Intrathecal adenosine administration: a phase 1 clinical safety study in healthy volunteers, with additional evaluation of its influence on sensory thresholds and experimental pain. | Q51490776 | ||
| Epidural ketamine reduces post-operative epidural PCA consumption of fentanyl/bupivacaine. | Q51527863 | ||
| Effect of spinal kainic acid receptor activation on spinal amino acid and prostaglandin E2 release in rat. | Q51558714 | ||
| Physiological contributions of neurokinin 1 receptor activation, and interactions with NMDA receptors, to inflammatory-evoked spinal c-Fos expression | Q60679679 | ||
| An A1-Selective Adenosine Agonist Abolishes Allodynia Elicited by Vibration and Touch After Intrathecal Injection | Q60683333 | ||
| AMPA/Kainate Receptor Antagonists as Novel Analgesic Agents | Q60718817 | ||
| Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin | Q69431040 | ||
| The effects of intrathecal neostigmine on somatic and visceral pain: improvement by association with a peripheral anticholinergic | Q71064530 | ||
| Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation | Q71256145 | ||
| Altered calcitonin gene-related peptide, substance P and enkephalin immunoreactivities and receptor binding sites in the dorsal spinal cord of the polyarthritic rat | Q71630981 | ||
| Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model | Q71659962 | ||
| Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons | Q71666735 | ||
| Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study | Q71852011 | ||
| Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application | Q72124185 | ||
| Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C | Q72240763 | ||
| Intrathecal delta-receptor ligand produces analgesia in man | Q72554052 | ||
| Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase | Q72684695 | ||
| Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice | Q72692259 | ||
| Small Intrathecal Doses of Lysine-Acetylsalicylate Relieve Intractable Pain in Man | Q72785003 | ||
| The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception | Q73275106 | ||
| [What is a nociceptor?] | Q73302242 | ||
| The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin | Q73485116 | ||
| Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord | Q73760403 | ||
| Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models | Q74296487 | ||
| Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat | Q74372681 | ||
| Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission | Q77581275 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 7680-7686 | |
| P577 | publication date | 1999-07-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | The spinal biology in humans and animals of pain states generated by persistent small afferent input | |
| P478 | volume | 96 |
| Q46065881 | Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats |
| Q48697449 | Alteration of medullary dorsal horn neuronal activity following inferior alveolar nerve transection in rats |
| Q43610769 | An automated flinch detecting system for use in the formalin nociceptive bioassay. |
| Q43558504 | Analgesia to pressure-pain develops in the ipsilateral forehead after high- and low-frequency electrical stimulation of the forearm |
| Q35064559 | Antagonism of nerve growth factor-TrkA signaling and the relief of pain |
| Q41921616 | Antinociceptive effect of some biuret derivatives on formalin test in mice |
| Q46713327 | Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions |
| Q41835834 | Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain |
| Q28191762 | Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models |
| Q73766092 | Bone cancer gain without the pain |
| Q40639418 | Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A2, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw. |
| Q35551507 | Bronchopulmonary afferent nerves |
| Q35967268 | Cell therapy for neuropathic pain in spinal cord injuries |
| Q37414465 | Central regulation of the cough reflex: therapeutic implications |
| Q35421957 | Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception |
| Q48666804 | Changes in amino acids and nitric oxide concentration in cerebrospinal fluid during labor pain |
| Q28365869 | Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice |
| Q42548830 | Combination Drug Therapy for Pain following Chronic Spinal Cord Injury |
| Q46306888 | Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice |
| Q38727831 | Current and Future Issues in the Development of Spinal Agents for the Management of Pain |
| Q35658521 | Current gene therapy using viral vectors for chronic pain |
| Q44589927 | Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation |
| Q30761400 | Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw. |
| Q36969685 | Distribution of Spinal Sensitization Evoked by Inflammatory Pain Using Local Spinal Cord Glucose Utilization Combined with (3) H-Phorbol 12,13-Dibutyrate Binding in Rats |
| Q48323251 | Dopamine D3 receptor specifically modulates motor and sensory symptoms in iron-deficient mice. |
| Q44182795 | Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats |
| Q44066792 | Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch |
| Q37177965 | Effect of Electroacupuncture Intervention on Expression of CGRP, SP, COX-1, and PGE2 of Dorsal Portion of the Cervical Spinal Cord in Rats with Neck-Incision Pain |
| Q28210737 | Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice |
| Q34007087 | Effect of clonidine as adjuvant in bupivacaine-induced supraclavicular brachial plexus block: A randomized controlled trial |
| Q37413759 | Effectiveness of adding ketamine to ropivacaine infusion via femoral nerve catheter after knee anterior cruciate ligament repair |
| Q37210075 | Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn |
| Q43809089 | Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord |
| Q33975112 | Emerging cell and molecular strategies for the study and treatment of painful peripheral neuropathies |
| Q41962544 | Ethanol withdrawal hyper‐responsiveness mediated by NMDA receptors in spinal cord motor neurons |
| Q60061940 | Expression and regulation of prostaglandin E receptor subtype mRNAs in rat sensory ganglia and spinal cord in response to peripheral inflammation |
| Q36457293 | Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways |
| Q44380439 | Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid |
| Q43702423 | High frequency electrical stimulation concurrently induces central sensitization and ipsilateral inhibitory pain modulation |
| Q80130959 | Impact of chronic nicotine on the development and maintenance of neuropathic hypersensitivity in the rat |
| Q40616071 | Indomethacin attenuates the immunosuppressive and tumor-promoting effects of surgery |
| Q44349317 | Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation |
| Q45230168 | Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats |
| Q44247459 | Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors |
| Q24553796 | Neuropathic pain: a practical guide for the clinician |
| Q40554185 | Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways |
| Q51385252 | Nitrous oxide analgesia--a 'sting in the tail'. |
| Q44007939 | Nociceptors and mediators in acute inflammatory pain |
| Q28250553 | Non-opioid analgesics for perioperative pain therapy. Risks and rational basis for use |
| Q44762691 | Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. |
| Q28196259 | Nonsteroidal anti-inflammatory agents in neonates |
| Q34303611 | Opioid-NMDA receptor interactions may clarify conditioned (associative) components of opioid analgesic tolerance. |
| Q34490380 | Overview of pain in the lame patient |
| Q43820595 | PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons |
| Q30722206 | Peripheral metabotropic glutamate receptors as drug targets for pain relief |
| Q30039702 | Polyanalgesic Consensus Conference 2012: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel |
| Q43832418 | Possible involvement of tachykinin NK(1) and NMDA receptors in histamine-induced hyperalgesia in mice |
| Q42218600 | Predifferentiated GABAergic neural precursor transplants for alleviation of dysesthetic central pain following excitotoxic spinal cord injury |
| Q60728707 | Proteases and Inflammatory Pain |
| Q44332303 | Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy |
| Q37115274 | Reduced acute nociception and chronic pain in Shank2-/- mice. |
| Q35203059 | Reflex mechanisms in gastroesophageal reflux disease and asthma |
| Q35086847 | Review article: visceral hypersensitivity |
| Q35048685 | Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse |
| Q73919665 | Selective suppression of inhibitory synaptic transmission by nocistatin in the rat spinal cord dorsal horn |
| Q37350085 | Short-term synaptic plasticity in the nociceptive thalamic-anterior cingulate pathway |
| Q73822604 | Spinal CSF from rats with painful peripheral neuropathy evokes catecholamine release from chromaffin cells in vitro |
| Q37965860 | Spinal Cord Stimulation Modulates Visceral Nociception and Hyperalgesia via the Spinothalamic Tracts and the Postsynaptic Dorsal Column Pathways: A Literature Review and Hypothesis |
| Q51360893 | Spinal allografts of adrenal medulla block nociceptive facilitation in the dorsal horn. |
| Q43263513 | Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats |
| Q28740599 | Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing |
| Q46134287 | Spinal cord stimulation reverses pain and diarrheal episodes of irritable bowel syndrome: a case report |
| Q35048741 | Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2 |
| Q37345025 | Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain |
| Q46624491 | Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs |
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| Q37149019 | The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain |
| Q43697187 | The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. |
| Q35779153 | The amygdala and persistent pain |
| Q51343489 | The anti-arthritic and anti-oxidative effect of NBD (6-nitro-1,3-benzodioxane) in adjuvant-induced arthritis (AIA) in rats. |
| Q34668480 | The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 - inflammatory profile of pain syndromes |
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