scholarly article | Q13442814 |
P356 | DOI | 10.1126/SCIENCE.1381521 |
P698 | PubMed publication ID | 1381521 |
P2093 | author name string | Yaksh TL | |
Malmberg AB | |||
P433 | issue | 5074 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | substance P | Q411041 |
P304 | page(s) | 1276-1279 | |
P577 | publication date | 1992-08-01 | |
P1433 | published in | Science | Q192864 |
P1476 | title | Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition | |
P478 | volume | 257 |
Q40394251 | A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization |
Q47850527 | A possible role for saliva as a diagnostic fluid in patients with chronic pain |
Q40932806 | A review on the strategies for the development and application of new anti-arthritic agents |
Q44209140 | A role for endocannabinoids in indomethacin-induced spinal antinociception |
Q44288444 | A spinal mechanism for the peripheral anti-inflammatory action of indomethacin |
Q92227580 | Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch |
Q28379551 | Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice |
Q41663135 | Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P |
Q41780863 | Acetaminophen prevents hyperalgesia in central pain cascade |
Q35633022 | Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord |
Q34809091 | Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization |
Q36449385 | Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons |
Q41809903 | Activin acts with nerve growth factor to regulate calcitonin gene-related peptide mRNA in sensory neurons |
Q34418309 | Acute pain management in children |
Q33649053 | Acute pain mechanisms |
Q37150552 | Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder |
Q72684125 | Advances in anti-inflammatory therapy |
Q40646776 | Altered pain perception and inflammatory response in mice lacking prostacyclin receptor |
Q40735769 | Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats |
Q38167857 | An intricate relationship between pain and depression: clinical correlates, coactivation factors and therapeutic targets |
Q40810874 | Analgesic effects of nonsteroidal anti-inflammatory drugs in cancer pain due to somatic or visceral mechanisms. |
Q34371837 | Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance |
Q70865314 | Antinociceptive activities of non-steroidal antiinflammatory drugs (NSAIDs) following intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration in mice |
Q35873011 | Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils |
Q28191762 | Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models |
Q73910670 | Apparent antinociceptive and anti-inflammatory effects of GYKI 52466 |
Q72033041 | Attenuation of NMDA-induced spinal hypersensitivity by adrenal medullary transplants |
Q41240200 | Biochemical aspects of chronic pain and its relationship to treatment |
Q45082670 | Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine |
Q38365855 | Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior |
Q46044403 | COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons |
Q24653404 | COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia |
Q37073724 | COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice |
Q24337300 | Calcium influx and protein kinase C alpha activation mediate arachidonic acid mobilization by the human NK-2 receptor expressed in Chinese hamster ovary cells |
Q40721486 | Central analgesic activity of nonsteroidal antiinflammatory drugs in animal and human pain models |
Q53961214 | Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes. |
Q34469703 | Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin |
Q44594631 | Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia |
Q48345104 | Central effect of ketorolac involving NMDA receptors activity. |
Q82028755 | Chapter 14 Descending excitatory systems |
Q28365869 | Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice |
Q42701449 | Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice |
Q41718971 | Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist |
Q43548479 | Characterization of the glutamatergic system for induction and maintenance of allodynia. |
Q43505670 | Chronic intrathecal cannulation enhances nociceptive responses in rats |
Q30360728 | Clinical Pharmacology and Cardiovascular Safety of Naproxen |
Q40328713 | Co-induction of cyclooxygenase-2 [correction of cyclooxyenase-2] and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia |
Q42757575 | Comparative effects of cyclo-oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance |
Q46669656 | Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. |
Q37699479 | Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans |
Q51507983 | Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels. |
Q51524955 | Controlled release gel of ibuprofen and lidocaine in epidural use--analgesia and systemic absorption in pigs. |
Q34139435 | Current experience with 5-HT3 receptor antagonists in fibromyalgia |
Q44589927 | Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation |
Q43621348 | Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes. |
Q41646498 | Cyclooxygenases and the central nervous system |
Q40473376 | Cytokine-to-brain communication: A review & analysis of alternative mechanisms |
Q44264983 | Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats |
Q73784501 | Differential potentiative effects of glutamate receptor antagonists in the production of antinociception induced by opioids administered intrathecally in the mouse |
Q33679568 | Distinct neurochemical features of acute and persistent pain |
Q33944600 | Distribution and function of prostanoid receptors: studies from knockout mice |
Q36969685 | Distribution of Spinal Sensitization Evoked by Inflammatory Pain Using Local Spinal Cord Glucose Utilization Combined with (3) H-Phorbol 12,13-Dibutyrate Binding in Rats |
Q34346670 | Dose-related effects of ibuprofen on pain-related potentials |
Q44004715 | Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain |
Q40604188 | Drug chirality: on the mechanism of R-aryl propionic acid class NSAIDs. Epimerization in humans and the clinical implications for the use of racemates |
Q35062919 | Drug therapy in dental practice: nonopioid and opioid analgesics |
Q35152153 | Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development |
Q45129816 | Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. |
Q42276965 | Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice |
Q36516256 | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial. |
Q53441224 | Effect of a single dose of meloxicam prior to band or knife castration in 1-wk-old beef calves: I. Acute pain. |
Q51557669 | Effect of pre- vs postoperative tonsillar infiltration with local anesthetics on postoperative pain after tonsillectomy. |
Q42453123 | Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices |
Q42023129 | Effect of the NMDA-antagonist, MK 801, on benzodiazepine-opioid interactions at the spinal and supraspinal level in rats |
Q74238294 | Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells |
Q34074682 | Effects of intrathecal ketorolac on human experimental pain |
Q39467172 | Effects of metamizol on nociceptive responses to stimulation of the ureter and on ureter motility in anaesthetised rats |
Q39419211 | Efficacy and safety of repeated postoperative administration of intramuscular diclofenac sodium in the treatment of post-cesarean section pain: a double-blind study |
Q34037670 | Electroacupuncture mediates extracellular signal-regulated kinase 1/2 pathways in the spinal cord of rats with inflammatory pain |
Q46083475 | Emerging drugs for neuropathic pain |
Q64889058 | Endoperoxide 4 receptors play a role in evoking the exercise pressor reflex in rats with simulated peripheral artery disease. |
Q42066400 | Evaluation of Postoperative Anti-nociceptive Efficacy of Intrathecal Dexketoprofen in Rats |
Q51577891 | Evaluation of periapical injection of Ketorolac for management of endodontic pain. |
Q42049298 | Evaluation of the combination of flurbiprofen and tramadol for management of endodontic pain |
Q60061940 | Expression and regulation of prostaglandin E receptor subtype mRNAs in rat sensory ganglia and spinal cord in response to peripheral inflammation |
Q34998028 | Function of prostanoid receptors: studies on knockout mice |
Q33784210 | Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat |
Q57990320 | GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain |
Q57318961 | Guidelines for Recognition, Assessment and Treatment of Pain |
Q74147278 | Hyperalgesia induced by peripheral inflammation is mediated by protein kinase C betaII isozyme in the rat spinal cord |
Q38326421 | Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites |
Q42706612 | In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs |
Q35028598 | In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin |
Q36007602 | Inflammatory mediators potentiate high affinity GABA(A) currents in rat dorsal root ganglion neurons |
Q43177787 | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. |
Q46973494 | Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia |
Q37740081 | Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs |
Q33939152 | Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity |
Q73676136 | Intrathecal N-methyl-D-aspartate (NMDA) induces paradoxical analgesia in the tail-flick test in rats |
Q44432820 | Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat |
Q50535515 | Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. |
Q71652889 | Intrathecal excitatory amino acid (EAA) agonists increase tail flick latencies (TFLs) of spinal rats |
Q34062378 | Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial |
Q71612212 | Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat |
Q41613425 | Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids |
Q34011229 | Is fibromyalgia a distinct clinical syndrome? |
Q39455901 | Ketorolac for postoperative pain management in children |
Q46920951 | Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat. |
Q44346622 | Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats |
Q77194690 | Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord |
Q53704943 | Lumbar epidural morphine infusions for children undergoing cardiac surgery. |
Q34040447 | Management of Inflammatory Pain with Selective COX-2 Inhibitors: Promises and Facts |
Q41078770 | Mechanisms of chronic pain |
Q78207290 | Mediation and modulation by eicosanoids of responses of spinal dorsal horn neurons to glutamate and substance P receptor agonists: results with indomethacin in the rat in vivo |
Q36374283 | Medical treatment of osteoarthritis in the horse - a review |
Q41815926 | Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons. |
Q33740802 | Modern concepts of paediatric analgesia |
Q28216291 | Molecular mechanisms of nociception |
Q78108265 | NMDA-induced spinal hypersensitivity is reduced by naturally derived peptide analog [Ser1]histogranin |
Q46378238 | NMDA-receptor regulation of substance P release from primary afferent nociceptors |
Q33664210 | NSAIDs and Acute Pancreatitis: A Systematic Review |
Q37929796 | Neoteric pharmacotherapeutic targets in fibromyalgia |
Q35030898 | Neurologic deficits and arachnoiditis following neuroaxial anesthesia |
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Q30834976 | Nitric oxide synthase and glutamate receptor immunoreactivity in the rat spinal trigeminal neurons expressing Fos protein after formalin injection |
Q41959104 | No preemptive analgesic effect of preoperative ketorolac administration following total abdominal hysterectomy: A randomized study |
Q44762691 | Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. |
Q41121621 | Nonopioid and opioid analgesic pharmacotherapy of cancer pain. |
Q72751829 | Nonsteroidal anti-inflammatory drugs |
Q39478947 | Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use. |
Q46647198 | Opioid-induced analgesia and hyperalgesia |
Q44807834 | Opioid-induced hyperalgesia. Pathophysiology and clinical relevance |
Q38157117 | Osteoarthritis of the hand II: chemistry, pharmacokinetics and pharmacodynamics of naproxen, and clinical outcome studies |
Q33822229 | Pain facilitatory circuits in the mammalian central nervous system: their behavioral significance and role in morphine analgesic tolerance |
Q36148700 | Pain management for dentists: the role of ibuprofen. |
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Q32052639 | Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches |
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Q32065380 | Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2. |
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Q35028007 | Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord |
Q37314270 | Peripheral mechanisms of pain and analgesia |
Q34282592 | Pharmacologic management of pain: the surgeon's responsibility. |
Q34185102 | Pharmacologic treatment of neuropathic pain |
Q36652103 | Pharmacological analysis of cyclooxygenase-1 in inflammation |
Q37915538 | Pharmacological treatment of opioid-induced hyperalgesia: a review of the evidence |
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Q43241364 | Postoperative pain control after cesarean section: can diclofenac sodium be used instead of meperidine? |
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Q39476283 | Pre-emptive Analgesia: A Systematic Review of Clinical Studies |
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Q38668522 | Preclinical Assessment of Inflammatory Pain |
Q39456105 | Principles of analgesic drug therapy. |
Q44341481 | Prior ibuprofen exposure does not augment opioid drug potency or modify opioid requirements for pain inhibition in total hip surgery |
Q46476096 | Production of prostaglandins D2 and E2 by mouse fibroblasts and astrocytes in culture caused by Trypanosoma brucei brucei products and endotoxin |
Q34199035 | Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord |
Q48556921 | Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. |
Q24801007 | Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link |
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Q51371003 | Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin. |
Q48771497 | Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients |
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