Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils

scientific article published in September 1995

Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.1995.TB16686.X
P932PMC publication ID1909089
P698PubMed publication ID8528583
P5875ResearchGate publication ID14671077

P2093author name stringWilliams AR
Rupniak NM
Webb JK
Hill RG
Boyce S
Carlson E
P2860cites workSpecies differences in affinities of non-peptide antagonists for substance p receptorsQ46925772
Differential effects of non-peptidic tachykinin receptor antagonists on Ca2+ channelsQ56987648
The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cordQ60679697
Time course of the alteration in dorsal horn substance p levels following formalin: blockade by naloxoneQ67661327
Non-specific inhibition of dopamine receptor agonist-induced behaviour by the tachykinin NK1 receptor antagonist CP-99,994 in guinea-pigsQ71666896
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin testQ71697377
Intrathecal morphine in mice: a new techniqueQ71852099
CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the ratQ72073185
Non-specific effects of the tachykinin NK1 receptor antagonist, CP-99,994, in antinociceptive tests in rat, mouse and gerbilQ72130439
Altered tachykinin expression by dorsal root ganglion neurons in a rat model of neuropathic painQ72397161
Ethical guidelines for investigations of experimental pain in conscious animalsQ29617510
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaQ29620385
Pharmacological properties of a potent and selective nonpeptide substance P antagonistQ37621800
Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulationQ37646935
Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisationQ41474244
Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptorQ41525212
Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.Q41764247
Non-specific activity of (+/-)-CP-96,345 in models of pain and inflammationQ41825174
The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, produces antinociceptive and anti‐oedema effects in the ratQ42238959
Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345Q42710885
Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat.Q42920499
Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.Q44774749
Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulationQ45156648
Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunctionQ46008800
(+/-)-CP-96,345, an NK1 receptor antagonist, has local anaesthetic-like effects in a mammalian sciatic nerve preparationQ46178031
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibitionQ46223466
The substance P receptor antagonist CP-96,345 interacts with Ca2+ channelsQ46414844
Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the ratQ46646080
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttachykinin receptorQ426034
P304page(s)1937-1943
P577publication date1995-09-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAntinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils
P478volume116

Reverse relations

cites work (P2860)
Q36104085Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.
Q41319496From acute to chronic pain: mechanisms and hypotheses.
Q48705594In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists
Q60682495Maturation of NK1 receptor involvement in the nociceptive response to formalin
Q41242320Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets
Q41757345The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles
Q38870522Transmission pathways and mediators as the basis for clinical pharmacology of pain

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