Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate.

scientific article published in October 1996

Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF02311085
P698PubMed publication ID8912014

P2093author name stringS H Ferreira
B B Lorenzetti
P2860cites workGlutamate spinal retrograde sensitization of primary sensory neurons associated with nociceptionQ34719658
Central and peripheral antialgesic action of aspirin-like drugsQ40700649
Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathwayQ41086458
Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious miceQ42276965
Excitatory amino acids are released from rat primary afferent neurons in vitroQ42464647
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.Q45267214
Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonistsQ46025693
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibitionQ46223466
Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neuronesQ46227920
Inhibition of nitric oxide synthesis by methylene blueQ50785727
Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.Q50878315
The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injuryQ67503828
Behavioural effects of receptor-specific substance P agonistsQ69017111
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious miceQ72692259
Spontaneous and evoked release of prostaglandins from frog spinal cordQ72883308
P433issue10
P921main subjectprostaglandin E2Q416554
P304page(s)499-502
P577publication date1996-10-01
P1433published inInflammation ResearchQ1819367
P1476titleIntrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate.
P478volume45

Reverse relations

cites work (P2860)
Q44288444A spinal mechanism for the peripheral anti-inflammatory action of indomethacin
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Q34422385Cellular and molecular actions of Methylene Blue in the nervous system
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Q43505670Chronic intrathecal cannulation enhances nociceptive responses in rats
Q32062037Direct activation of rat spinal dorsal horn neurons by prostaglandin E2.
Q43809089Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord
Q37624813Increased interleukin-1α and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation
Q34793517Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells
Q39007494Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain
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Q62056185The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord

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