Apparent antinociceptive and anti-inflammatory effects of GYKI 52466

scientific article published on 01 October 1997

Apparent antinociceptive and anti-inflammatory effects of GYKI 52466 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-2999(97)01262-4
P698PubMed publication ID9384226

P2093author name stringTörök K
Székely JI
Tarnawa I
Kedves R
Máté I
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Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmittersQ39370851
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New pharmacological strategies for pain reliefQ39469281
The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammationQ41102806
Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo studyQ42370058
Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependenceQ42371046
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathyQ43547058
Antinociceptive effects of mu- and kappa-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanismQ44343710
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Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibitionQ46223466
Glutamate participates in the peripheral modulation of thermal hyperalgesia in ratsQ47631048
Intrathecal co-administration of morphine and excitatory amino acid agonists produce differential effects on the tail-flick of intact and spinal ratsQ48154752
Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.Q48193147
A novel specific binding site for homophthalazines in the rat brain.Q48285497
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Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655Q48346752
Differential effects of NMDA and non-NMDA receptor antagonists on spinal cutaneous vs muscular nociception in the cat.Q48387201
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responsesQ48392369
MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathyQ48690138
Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466.Q51750154
The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity statesQ52237708
UPREGULATION OF SPINAL GLUTAMATE RECEPTORS IN CHRONIC PAINQ58852488
GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 miceQ60639364
Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the ratQ68083253
Receptor site specificity for the acute effects of beta-N-methylamino-alanine in miceQ68165011
Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 miceQ70612498
AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmissionQ71640817
The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in ratsQ72049202
Selective antinociceptive effect of excitatory amino acid antagonists in intact and acute spinal ratsQ72061477
GYKI 52466 inhibits AMPA/kainate and peripheral mechanical sensory activityQ72130883
Joint inflammation and hyperalgesia are reduced by spinal bicucullineQ72249070
Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammationQ72667869
Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the ratQ72830126
P433issue2-3
P304page(s)143-154
P577publication date1997-10-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleApparent antinociceptive and anti-inflammatory effects of GYKI 52466
P478volume336

Reverse relations

cites work (P2860)
Q34314547Glutamate receptors and nociception: implications for the drug treatment of pain
Q42016580Kainate receptors are primarily postsynaptic to SP-containing axon terminals in the trigeminal dorsal horn
Q33863397Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders
Q39019429Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats
Q74582907The distribution of neurons expressing calcium-permeable AMPA receptors in the superficial laminae of the spinal cord dorsal horn
Q48284194The induction of pain: an integrative review

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