Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use.

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Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1019189671
P356DOI10.2165/00003495-199549010-00005
P698PubMed publication ID7705216

P50authorGregory McanultyQ71397574
P2093author name stringJ Cashman
P2860cites workIndomethacin and aspirin abolish prostaglandin release from the spleenQ28251299
Conformational requirements at the prostaglandin cyclooxygenase receptor site: A template for designing non-steroidal anti-inflammatory drugsQ28319283
Renal disease and use of topical non-steroidal anti-inflammatory drugsQ28378469
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugsQ29617192
Indomethacin in rheumatoid arthritis: clinical effects, pharmacokinetics, and platelet studies in responders and nonrespondersQ33551852
Stereoselective analysis of ketorolac in human plasma by high-performance liquid chromatographyQ70596966
Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritisQ71440415
Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesisQ71508323
Aspirin and the stomachQ71532174
Influence of the route of administration on the area under the plasma concentration-time curveQ72340804
Double-blind controlled trial of indomethacin as an adjunct to narcotic analgesia after major abdominal surgeryQ72528573
Inflammation and hyperalgesia: highlighting the team effortQ72628890
Aspirin-induced asthmaQ72633749
Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugsQ72674958
Small Intrathecal Doses of Lysine-Acetylsalicylate Relieve Intractable Pain in ManQ72785003
Kinetics of pharmacologic effectsQ72847354
Influence of the route of administration on the pharmacokinetics of pirprofen enantiomers in the ratQ72861707
On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)Q80329338
Demonstration of specific E-type prostaglandin receptors using enriched preparations of canine parietal cells and [3H]misoprostol free acidQ69903894
Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agentsQ69964826
A clinical evaluation of a sustained-release aspirinQ69977768
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritisQ34403797
Variability in response to nonsteroidal anti-inflammatory analgesics: evidence from controlled clinical therapeutic trial of flurbiprofen in rheumatoid arthritisQ34418215
Efficacy and pharmacokinetics of aspirin in post-operative dental painQ34449921
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction proteinQ34481430
Variations in responses to non-steroidal anti-inflammatory drugsQ34511202
Clinical pharmacokinetics of salicylates: a re-assessmentQ34519571
Effect of aspirin in "aspirin sensitive" patientsQ34556450
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activityQ34602844
Stereoselective disposition of ibuprofen enantiomers in manQ34622724
Prostaglandins, Aspirin-like Drugs and AnalgesiaQ34699629
Intravenous indomethacin or oxycodone in prevention of post-operative pain.Q34995752
Acetylation of prostaglandin synthase by aspirinQ35085661
Potential Renal, Haematological and Allergic Adverse Effects Associated with Nonsteroidal Anti-Inflammatory DrugsQ35170419
Are Perioperative Nonsteroidal Anti-Inflammatory Drugs Ulcerogenic in the Short Term?Q35170421
The effect of acetylsalicylic acid on renal function in the Pekin duckQ36003965
Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacyQ36660298
Misoprostol--a logical therapeutic approach to gastroduodenal mucosal injury induced by non-steroidal anti-inflammatory drugs?Q36911181
Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugsQ37464266
Nonsteroidal anti-inflammatory drugs and peptic ulcer diseaseQ37624998
Nonsteroidal antiinflammatory drugs--differences and similaritiesQ37719404
The mode of action of anti-inflammatory drugsQ37832319
Pain relief after major gynaecological surgeryQ39486706
Preoperative indomethacin for pain relief after thoracotomy: comparison with postoperative indomethacinQ39495241
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.Q39495280
IV diclofenac in post-thoracotomy painQ39501976
Administration of lysine acetylsalicylate and meperidine in acute postoperative painQ39502344
Comparison of intravenous diclofenac, indomethacin and oxycodone as post-operative analgesics in patients undergoing knee surgeryQ39504301
Effect of indomethacin on pain relief after thoracotomyQ39514170
A multiple-dose comparison of ketorolac tromethamine with diflunisal and placebo in postmeniscectomy painQ39541367
Comparison of infusions of morphine and lysine acetyl salicylate for the relief of pain following thoracic surgeryQ39549995
Comparison of infusions of morphine and lysine acetyl salicylate for the relief of pain after surgeryQ39550002
Diclofenac for pain after hip surgeryQ39550378
The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequencesQ40092311
Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonistsQ40122474
Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesicsQ40294198
The mode of action of aspirin and similar compoundsQ40627989
Central and peripheral antialgesic action of aspirin-like drugsQ40700649
Prostacyclin as a potent dilator of arterioles in the hamster cheek pouch [proceedings]Q40869977
The hyperalgesic effects of prostacyclin and prostaglandin E2Q40948882
Inflammatory effects of prostacyclin (PGI2) and 6-oxo-PGF1α in the rat pawQ40948895
Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs--1. In vitro studies of ibuprofen and flurbiprofenQ41284725
Central analgesic effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over studyQ41323889
Variations in response to non-steroidal anti-inflammatory drugsQ41905119
Anti-inflammatory analgesic drug responders and non-responders: a clinico-pharmacological study of flurbiprofenQ41990007
Stereoselective disposition of ibuprofen enantiomers in synovial fluidQ42213910
Effects of anti-inflammatory drugs on prostaglandin biosynthesisQ42233235
Acute renal failure associated with intramuscular ketorolac.Q42287082
Renal failure and hyperkalemia associated with ketorolac tromethamineQ42558552
Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findingsQ42713139
S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritisQ43457156
Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzymeQ43949902
The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers: a gastroscopic and photographic studyQ44064730
The role of prostaglandins in the control of renal functionQ44149149
Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferentsQ44348601
The morphine sparing effects of diclofenac sodium following abdominal surgeryQ44901965
Drugs which inhibit prostaglandin biosynthesisQ45293232
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibitionQ46223466
Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamusQ49027269
Treatment of postoperative pain. Double-blind comparison of diclofenac and pentazocineQ50184101
Multimodal analgesia before thoracic surgery does not reduce postoperative pain.Q51628835
Effects of ketorolac trometamol on renal function.Q51690950
Double-blind comparison of the morphine sparing effect of continuous and intermittent i.m. administration of ketorolac.Q51706652
Intravenous diclofenac sodium. Does its administration before operation suppress postoperative pain?Q51727835
Indomethacin as an analgesic after hysterectomy.Q51750309
The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery.Q51788868
Variance in NSAID studies: contribution of patient variance.Q52682572
New Method for Calculating the Intrinsic Absorption Rate of DrugsQ53021749
The analgesic effect of indomethacin in the early post-operative period following abdominal surgery. A double-blind controlled studyQ57071022
Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioestersQ57415346
The stereoselective uptake of ibuprofen enantiomers into adipose tissueQ57415361
Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugsQ57945428
Pharmacokinetics and biochemical effects in responders and non-responders to non-steroidal anti-inflammatory drugs.Q65002766
Four new anti-inflammatory drugs: responses and variationsQ67481302
Stereoselective systemic disposition of ibuprofen enantiomers in the dogQ67852136
Pharmacokinetics of ibuprofen enantiomers after single and repeated doses in manQ68009664
Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, sodium diclofenacQ68032986
Prostaglandin biosynthesis: consequences of oxygenase mechanism upon in vitro assays of drug effectivenessQ68288526
Treatment and prevention of NSAID induced gastroduodenal mucosal damageQ68300894
Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparisonQ68504271
The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleedingQ68812075
Ibuprofen in the management of postoperative painQ68921775
Similar effects of acetylsalicylic acid and morphine on immediate responses to acute noxious stimulationQ69038097
Misoprostol heals gastroduodenal injury in patients with rheumatoid arthritis receiving aspirinQ69189585
Topical non-steroidal anti-inflammatory drugsQ69376508
Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcerQ69482364
The clinical dose response to aspirinQ69842504
Variability in response to NSAIDQ69853646
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
pain managementQ621261
P1104number of pages20
P304page(s)51-70
P577publication date1995-01-01
P1433published inDrugsQ3040094
P1476titleNonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use
P478volume49

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cites work (P2860)
Q35847296A Comparative Efficacy of Propacetamol and Ketorolac in Postoperative Patient Controlled Analgesia
Q50098732Analgesic, Antiinflammatory, and Antipyretic Effects of S(+)-Ketoprofen In Vivo
Q41217588Chirality and nonsteroidal anti-inflammatory drugs
Q34257894Clinical pharmacokinetics of dexketoprofen
Q35204319Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial
Q50098747Comparison of Dexketoprofen Trometamol and Ketoprofen in the Treatment of Osteoarthritis of the Knee
Q39379158Comparison of rofecoxib and oxycodone plus acetaminophen in the treatment of acute pain: a randomized, double-blind, placebo-controlled study in patients with moderate to severe postoperative pain in the third molar extraction model
Q24240354Diclofenac for acute pain in children
Q24246170Diclofenac for acute pain in children
Q39467450Evaluation and management of chronic pelvic pain
Q39345716Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery
Q38168838Intravenous paracetamol reduces postoperative opioid consumption after orthopedic surgery: a systematic review of clinical trials
Q39459778Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management
Q55258705Magnetic field distribution modulation of intrathecal delivered ketorolac iron-oxide nanoparticle conjugates produce excellent analgesia for chronic inflammatory pain.
Q35179307Maximizing the safety of nonsteroidal anti-inflammatory drug use for postoperative dental pain: an evidence-based approach.
Q33948672Nimesulide: some pharmaceutical and pharmacological aspects--an update
Q47138648Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
Q73434556Platelet dysfunction after intravenous ketorolac or propacetamol
Q80221603Pre-emptive and postoperative analgesia for dentoalveolar surgery
Q39468679Preclinical and clinical development of dexketoprofen
Q33651424Selective cyclooxygenase-2 inhibitors
Q33915681The effects of paracetamol, ketorolac, and paracetamol plus morphine on pain control after thyroidectomy
Q33542921The use of analgesics in the management of pain in rheumatic diseases
Q24186675WITHDRAWN: Diclofenac for acute pain in children
Q77339493[Role of non-steroidal anti-inflammatory agents in the perioperative period. Usefulness and limitations]

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