Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

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Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084821422
P356DOI10.1038/S41598-017-01056-0
P8608Fatcat IDrelease_hm5nyz3tsfc43ddh6udfvag4ka
P932PMC publication ID5430524
P698PubMed publication ID28428622

P2093author name stringYong Huo
Wei Yang
Ping Wang
Lin Wu
Lu Ren
Xiao-Hong Wei
Si-Hui Huang
Yan-Sheng Ding
Shan-Dong Yu
Qiao-Mei Yang
Yan-Peng Chu
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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismQ28117072
Inhibitors of arachidonate-regulated calcium channel signaling suppress triggered activity induced by the late sodium currentQ54407541
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytesQ54541558
Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusionQ64376598
Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarizationQ86741949
Atrial remodeling and atrial fibrillation: recent advances and translational perspectivesQ87419203
Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In VivoQ30973910
BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes.Q32112785
Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia.Q33147854
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarizationQ33641630
Resveratrol Attenuates the Na+-Dependent Intracellular Ca2+ Overload by Inhibiting H2O2-Induced Increase in Late Sodium Current in Ventricular MyocytesQ34525246
Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644.Q36433860
Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.Q36628319
The link between abnormal calcium handling and electrical instability in acquired long QT syndrome--Does calcium precipitate arrhythmic storms?Q36730574
Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modificationQ36952000
Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies.Q36975788
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidineQ37159534
Pathophysiology and pharmacology of the cardiac "late sodium current.".Q37228932
SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.Q37418216
Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.Q37735504
Inherited calcium channelopathies in the pathophysiology of arrhythmiasQ38021673
Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndromeQ38098506
Regulation of Ca(2+) transient by PP2A in normal and failing heartQ38358069
Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin—Increased Late Sodium Current in Rabbit Ventricular MyocytesQ39240103
Stretch current-induced abnormal impulses in CaMKIIδ knockout mouse ventricular myocytesQ39646211
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heartQ39826487
Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.Q41016215
Cardiac ultrastructural abnormalities in Syrian hamsters with spontaneous cardiomyopathy or subjected to cardiac overloadsQ41112140
Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanismsQ42065538
Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channelsQ42234927
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S miceQ43669272
Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathyQ43741617
Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndromeQ44805574
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic PropertiesQ46120532
An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit heartsQ46761474
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)981
P577publication date2017-04-20
P1433published inScientific ReportsQ2261792
P1476titleInhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions
P478volume7

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cites work (P2860)
Q58121711Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium
Q47139105Notoginsenoside R1 Alleviates Oxygen-Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC.
Q64087343Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

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