Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin—Increased Late Sodium Current in Rabbit Ventricular Myocytes

scientific article published on October 1, 2012

Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin—Increased Late Sodium Current in Rabbit Ventricular Myocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/FJC.0B013E318262C932
P953full work available at URLhttps://journals.lww.com/10.1097/FJC.0b013e318262c932
P698PubMed publication ID23064241

P2093author name stringShuo Zhang
Ji-Hua Ma
Pei-Hua Zhang
An-Tao Luo
Ling-Hao Kong
Zhi-Qiang Ren
P2860cites workAnti-nociceptive and anti-inflammatory activity of sophocarpine.Q45927781
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Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytesQ46550780
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulationQ46624550
Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytesQ46689827
Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injuryQ46716871
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytesQ46725746
An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit heartsQ46761474
Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytesQ48196534
Effects of ApC, a sea anemone toxin, on sodium currents of mammalian neuronsQ48445874
Anemone toxin (ATX II)-induced increase in persistent sodium current: effects on the firing properties of rat neocortical pyramidal neuronesQ48496496
The sea anemone toxins BgII and BgIII prolong the inactivation time course of the tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons.Q49012140
Hypoxia increases persistent sodium current in rat ventricular myocytesQ51556510
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loadingQ51630231
Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunctionQ53630608
Congenital long QT syndromeQ58010712
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchangeQ67494061
Electrical heterogeneity, cardiac arrhythmias, and the sodium channelQ73221469
Induction of persistent sodium current by exogenous and endogenous nitric oxideQ73838505
Relation between Spontaneous Contraction and Sarcoplasmic Reticulum Function in Cultured Neonatal Rat Cardiac MyocytesQ74844210
Gating of the late Na+ channel in normal and failing human myocardiumQ78513854
Vitamin C pretreatment attenuates hypoxia-induced disturbance of sodium currents in guinea pig ventricular myocytesQ79242530
Sodium channel gating modes during redox reactionQ79798982
Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for LessQ81097337
Sophocarpine alleviates non-alcoholic steatohepatitis in ratsQ82333268
Yao xue xue baoQ26853820
Acta Pharmacologica SinicaQ27708787
Distribution of a persistent sodium current across the ventricular wall in guinea pigsQ28143616
Hypoxia and persistent sodium current.Q30331627
Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injuryQ33194970
Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heartQ33493045
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarizationQ33641630
Sodium/calcium exchange: its physiological implicationsQ33676901
Cardiac ionic currents and acute ischemia: from channels to arrhythmiasQ33676912
Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failureQ33936393
Effects of the Anemonia sulcata toxin (ATX II) on intracellular sodium and contractility in rat and guinea-pig myocardiumQ34321583
Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.Q34323654
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic propertiesQ34339876
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.Q34571615
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium currentQ34693729
Forefront of Na+/Ca2+ exchanger studies: role of Na+/Ca2+ exchanger--lessons from knockout miceQ35883522
Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heartQ36954069
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidineQ37159534
A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazineQ37427347
Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agentQ37728831
Role of ranolazine in angina, heart failure, arrhythmias, and diabetesQ37963638
Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathwaysQ39462224
Comparative effects of sophocarpine and sophoridine on hERG K+ channelQ39882551
Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in miceQ39942531
HERG K+ channel blockade by the novel antiviral drug sophocarpineQ39996591
Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-κB inactivationQ40328939
Role of Intracellular Sodium Overload in the Genesis of Cardiac ArrhythmiasQ41520008
Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injuryQ43686059
In vitro Inhibition of HHV-6 replication by sophocarpinesQ43947559
Importance of Ca2+ influx by Na+/Ca2+ exchange under normal and sodium-loaded conditions in mammalian ventriclesQ44348268
Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndromeQ44805574
Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytesQ44970567
Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.Q45284438
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectAnemonia sulcataQ5293826
P304page(s)357-366
P577publication date2012-10-01
P1433published inJournal of Cardiovascular PharmacologyQ2125808
P1476titleSophocarpine attenuates the Na(+)-dependent Ca2(+) overload induced by Anemonia sulcata toxin-increased late sodium current in rabbit ventricular myocytes
Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin—Increased Late Sodium Current in Rabbit Ventricular Myocytes
P478volume60

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cites work (P2860)
Q41868437Andrographolide inhibits arrhythmias and is cardioprotective in rabbits
Q33681289Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions
Q36254549Ketamine attenuates the Na+-dependent Ca2+ overload in rabbit ventricular myocytes in vitro by inhibiting late Na+ and L-type Ca2+ currents
Q38204723New antiarrhythmic targets to control intracellular calcium handling
Q53629078Protein kinase C and Ca(2+) -calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit ventricular myocytes
Q34525246Resveratrol Attenuates the Na+-Dependent Intracellular Ca2+ Overload by Inhibiting H2O2-Induced Increase in Late Sodium Current in Ventricular Myocytes
Q33604007The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms
Q37399383Tolterodine reduces veratridine-augmented late INa, reverse-INCX and early afterdepolarizations in isolated rabbit ventricular myocytes
Q48252718Wenxin Keli diminishes Ca2+ overload induced by hypoxia/reoxygenation in cardiomyocytes through inhibiting INaL and ICaL.

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