The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans

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The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI23048
P932PMC publication ID1051994
P698PubMed publication ID15765146

P50authorTibor Valyi-NagyQ96270950
John PanepintoQ124261626
P2093author name stringPeter R Williamson
Jianmin Fu
Saliha Eksi
Xudong Zhu
Brian Wickes
Lide Liu
H Ari Jaffe
Jeanie Ramos
P2860cites workFunctional characterization of the S. cerevisiae genome by gene deletion and parallel analysisQ27860815
Isolation and characterization of the gene encoding phosphoenolpyruvate carboxykinase from Saccharomyces cerevisiaeQ27930212
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing BodiesQ27931286
The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.Q27932152
Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexesQ27935131
Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiaeQ27935904
Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiaeQ27937817
Cryptococcus neoformans STE12alpha regulates virulence but is not essential for matingQ27939881
The glyoxylate cycle is required for fungal virulenceQ28206225
The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissuesQ28293569
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.Q30424017
Use of cerebrospinal fluid lactic acid concentration in the diagnosis of fungal meningitisQ30463293
Melanization of Cryptococcus neoformans in murine infectionQ31951268
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.Q33612121
Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformansQ33753934
Urease as a virulence factor in experimental cryptococcosisQ33886908
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformansQ33968048
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.Q33999899
Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophagesQ34002542
Laccase of Cryptococcus neoformans is a cell wall-associated virulence factorQ34008955
Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-Cell responsesQ34132009
Cryptococcosis: clinical and biological aspectsQ34154530
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformansQ34608349
RNA interference in the pathogenic fungus Cryptococcus neoformansQ34614419
Cloning, sequence analysis, and expression of ligninolytic phenoloxidase genes of the white-rot basidiomycete Coriolus hirsutusQ34942558
Genetics of Cryptococcus neoformansQ34995484
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.Q35197981
Global control of gene expression in yeast by the Ccr4-Not complexQ35212570
The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence.Q35495143
Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 geneQ35546019
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cellsQ35864616
Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.Q35953363
Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformansQ36045927
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccaseQ36105023
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformansQ36367081
Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulenceQ36657718
The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.Q36739266
Genetic association of mating types and virulence in Cryptococcus neoformansQ36958159
Cryptococcus neoformans: Gastronomic delight of a soil amebaQ38483173
Cryptococcal infection in a cohort of HIV-1-infected Ugandan adultsQ38884510
Natural habitat of Cryptococcus neoformans var. neoformans in decaying wood forming hollows in living treesQ39426670
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformansQ39618708
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformansQ40836371
Calcineurin is required for virulence of Cryptococcus neoformansQ42617596
Further analysis of the CAP59 locus of Cryptococcus neoformans: structure defined by forced expression and description of a new ribosomal protein-encoding geneQ42626369
The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negativelyQ42638627
Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicityQ43612702
Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide.Q43796047
Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1.Q43818294
Identification of metabolites of importance in the pathogenesis of pulmonary cryptococcoma using nuclear magnetic resonance spectroscopyQ44410707
Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes.Q46769778
The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specificQ46902678
Mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans is a zinc-containing long-chain alcohol/polyol dehydrogenase.Q47824197
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformansQ47863650
Dominant selection system for use in Cryptococcus neoformans.Q54577694
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformansQ62629892
Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformansQ62633172
Multiple signalling pathways trigger the exquisite sensitivity of yeast gluconeogenic mRNAs to glucoseQ71504307
Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformansQ71817869
Disseminated cryptococcal infection in immune competent patientsQ73725606
Haploid fruiting in Cryptococcus neoformans is not mating type alpha-specificQ73738271
A novel episomal shuttle vector for transformation of Cryptococcus neoformans with the ccdB gene as a positive selection marker in bacteriaQ73827973
Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusionQ73949020
Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicaseQ77130166
Immune reconstitution cryptococcosis after initiation of successful highly active antiretroviral therapyQ78627263
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCryptococcus neoformansQ131924
virulence associated ATP-dependent mRNA helicaseQ62631633
translation elongation factor TuQ62889630
ATP-dependent RNA helicase VAD1Q62905967
P304page(s)632-641
P577publication date2005-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleThe DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans
P478volume115

Reverse relations

cites work (P2860)
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Q36754718Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence
Q34961874Introns regulate gene expression in Cryptococcus neoformans in a Pab2p dependent pathway
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Q35611515New technology and resources for cryptococcal research
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Q62905967ATP-dependent RNA helicase VAD1described by sourceP1343

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