Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans

scientific article published on 8 February 2007

Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI30006
P932PMC publication ID1784002
P698PubMed publication ID17290306
P5875ResearchGate publication ID6515245

P50authorTibor Valyi-NagyQ96270950
John PanepintoQ124261626
P2093author name stringPeter R Williamson
Yoon-Dong Park
Xudong Zhu
Shahid Husain
Nina Singh
Scott R Waterman
Craig Beam
Soowan Shin
Guowu Hu
Moshe Hacham
P2860cites workMAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeastQ27938740
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformansQ28354724
Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasmQ30476172
An efficiently regulated promoter system for Cryptococcus neoformans utilizing the CTR4 promoterQ30954801
Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infectionQ33598508
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformansQ33683735
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascadeQ33719196
Urease as a virulence factor in experimental cryptococcosisQ33886908
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of AmericaQ33898624
Phenotypic switching in Candida glabrata accompanied by changes in expression of genes with deduced functions in copper detoxification and stressQ33995600
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.Q33999899
Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophagesQ34532068
Transition metal transport in yeastQ34762758
The damage-response framework of microbial pathogenesisQ35709086
From aging to virulence: forging connections through the study of copper homeostasis in eukaryotic microorganismsQ35737975
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccaseQ36105023
Pulmonary fungal infection with yeasts and pneumocystis in patients with hematological malignancy.Q36194915
Trace metal regulation of neuronal apoptosis: from genes to behaviorQ36241919
Fungal CNS infections in patients with hematologic malignancy.Q36278069
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformansQ36367081
Evolution of protein fold in the presence of functional constraintsQ36464994
Intersection of fungal fitness and virulence in Cryptococcus neoformansQ36476676
CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistenceQ36575404
Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channelsQ36795682
Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron effluxQ36851918
Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformansQ36956326
Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrierQ37521730
The fission yeast copper-sensing transcription factor Cuf1 regulates the copper transporter gene expression through an Ace1/Amt1-like recognition sequenceQ38302567
Role of a VPS41 homologue in starvation response, intracellular survival and virulence of Cryptococcus neoformansQ40249599
Visualization of nitric oxide in living cells by a copper-based fluorescent probeQ40274302
Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimensQ40771289
Gamma delta + T cells in Wilson's disease.Q40959618
Copper induces cytoplasmic retention of fission yeast transcription factor cuf1.Q41823951
Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1.Q43818294
Micronutrients in HIV-infection and the relationship with the inflammatory responseQ44276549
The Schizosaccharomyces pombe Cuf1 is composed of functional modules from two distinct classes of copper metalloregulatory transcription factors.Q44310055
A CLC‐type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformansQ44658462
Quantitative analysis of phagolysosome fusion in intact cells: inhibition by mycobacterial lipoarabinomannan and rescue by an 1alpha,25-dihydroxyvitamin D3-phosphoinositide 3-kinase pathwayQ44848244
Melanin-deficient mutants of Cryptococcus neoformans.Q46102131
An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipientsQ46503386
Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infectionQ46797332
A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.Q47902129
The yeast Cryptococcus neoformans uses 'mammalian' enhancer sites in the regulation of the virulence gene, CNLAC1.Q47987302
Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25H expressed in yeast and purified using nickel-NTA agaroseQ48004480
Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environmentQ48251808
Liver transplantation: the Italian experienceQ48616512
Serum copper concentration in HIV-infection patients and relationships with other biochemical indices.Q50871706
The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1.Q51646269
Dominant selection system for use in Cryptococcus neoformans.Q54577694
Allograft Loss in Renal Transplant Recipients with Cryptococcus Neoformans Associated Immune Reconstitution SyndromeQ57569326
Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusionQ73949020
Augmented metalloproteinase activity and acute lung injury in copper-deficient ratsQ74129504
The clinical epidemiology of pulmonary cryptococcosis in non-AIDS patients at a tertiary care medical centerQ74500230
Cryptococcaemia: clinical features and prognostic factorsQ74530603
Immune reconstitution cryptococcosis after initiation of successful highly active antiretroviral therapyQ78627263
Cryptococcus neoformans var. gattii can exploit Acanthamoeba castellanii for growthQ80046392
Translational and clinical science--time for a new visionQ81344965
CaMac1, a Candida albicans copper ion-sensing transcription factor, promotes filamentous and invasive growth in Saccharomyces cerevisiaeQ82736005
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcopperQ753
Cryptococcus neoformansQ131924
Copper uptake transporterQ62632259
Copper uptake transporterQ62872354
Copper uptake transporterQ62872359
Copper uptake transporterQ62872365
Copper uptake transporterQ62872369
Metal-binding regulatory protein CUF1Q62890674
P304page(s)794-802
P577publication date2007-02-08
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleRole of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans
P478volume117

Reverse relations

described by source (P1343)
Q62632259Copper uptake transporter
Q62872354Copper uptake transporter
Q62872359Copper uptake transporter
Q62872365Copper uptake transporter
Q62872369Copper uptake transporter

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