Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma

scientific article

Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.15645
P932PMC publication ID5438684
P698PubMed publication ID28404924

P50authorScott KopetzQ51789838
Jaffer AjaniQ64913003
Sunil KrishnanQ89944934
Dipen MaruQ91302122
Wayne L. HofstetterQ107450763
Sushovan GuhaQ114453617
Zhimin TongQ114453640
Omkara VeerankiQ114453641
P2093author name stringSteven Lin
Defeng Deng
Alicia Mejia
Devkumar Chatterjee
P2860cites workCDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression.Q36962507
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseasesQ37333518
Barrett's esophagus: diagnostic challenges and recent developmentsQ37477732
Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancersQ37536656
Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancerQ37636710
Targeting cyclin-dependent kinases in anti-neoplastic therapyQ38135008
Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosisQ38332838
EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancerQ38392935
Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.Q39577806
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiationQ39895438
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effectsQ40216003
Biomarker analysis in oesophagogastric cancer: Results from the REAL3 and TransMAGIC trialsQ44261463
Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancerQ46487396
The selective P-TEFb inhibitor CAN508 targets angiogenesis.Q54572692
Changes in age, stage distribution, and survival of patients with esophageal adenocarcinoma over three decades in the United StatesQ82749733
Anti-phosphorylated histone H3 expression in Barrett's esophagus, low-grade dysplasia, high-grade dysplasia, and adenocarcinomaQ84522311
The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508Q27676963
Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expressionQ28146067
Cdks, cyclins and CKIs: roles beyond cell cycle regulationQ28294632
Cancer statistics, 2016Q29547383
Mcl-1 ubiquitination: unique regulation of an essential survival proteinQ33883844
A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261Q34023223
PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cellsQ34140712
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaQ34342934
Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancerQ35037270
Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junctionQ35208151
Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemiaQ35550068
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemiaQ35615823
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomasQ35681702
Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation.Q35868187
Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal AdenocarcinomaQ36547753
Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testisQ36565158
Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.Q36610386
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)28696-28710
P577publication date2017-04-01
P1433published inOncotargetQ1573155
P1476titleAntitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma
P478volume8

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cites work (P2860)
Q59797085Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma
Q92434462Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma
Q92434912Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma

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