Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas

scientific article published on January 2012

Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-11-2272
P8608Fatcat IDrelease_wd5nfilr75g7vbybu5sdmr2syu
P932PMC publication ID3261584
P698PubMed publication ID22252257

P2093author name stringQian Shi
Tsung-Teh Wu
Axel Grothey
William R Sukov
Harry H Yoon
Robert B Diasio
Robert B Jenkins
Frank A Sinicrope
Maliha Khan
Christopher A Sattler
Anne E Wiktor
P2860cites workAdenocarcinomas of esophagus and cardia in comparison with gastric carcinomaQ72680681
Adenocarcinomas of the distal oesophagus and gastric cardia are one clinical entity. Rotterdam Oesophageal Tumour Study GroupQ77363051
Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagusQ79401515
HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trialQ79816337
The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidenceQ81290009
HER-2/neu expression in locally advanced breast carcinomas: pre-and post-neoadjuvant chemotherapyQ81478000
Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinomaQ81621756
Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelinesQ83722585
Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesisQ24602426
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequenceQ30837765
Cancer of the esophagus and esophagogastric junction: data-driven staging for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer Cancer Staging ManualsQ33610263
Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagusQ33611018
The prognostic value of clinical and pathologic factors in esophageal adenocarcinoma: a mayo cohort of 796 patients with extended follow-up after surgical resectionQ34374254
Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific reviewQ34605352
Clinicopathologic factors associated with HER2-positive gastric cancer and its impact on survival outcomes--a systematic reviewQ34631121
Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagusQ34761782
HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma.Q35111575
The national practice for patients receiving radiation therapy for carcinoma of the esophagus: results of the 1996-1999 Patterns of Care StudyQ35163880
Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.Q35354276
Chemoradiation in the management of esophageal cancerQ36935105
Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patientsQ37135262
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (IBC): analysis of 2,014 IBC patient cases from the California Cancer RegistryQ37205563
c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett's oesophagusQ37256684
Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancerQ37626334
HER2 testing in gastric cancerQ37822236
Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival.Q38412375
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer StudyQ39605778
Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagusQ39977382
Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia.Q40622495
HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testingQ42431264
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence ratesQ42521534
Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer--a study from the IMPACT trialistsQ46378890
Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance.Q51741363
Comprehensive analysis of HER2 expression and gene amplification in gastric cancers using immunohistochemistry and in situ hybridization: which scoring system should we use?Q53410042
Assessment of ErbB2 (Her2) in oesophageal adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisation.Q54594739
Expression of Her-2 in carcinomas of the esophagus.Q54630658
HER-2 amplification is highly homogenous in gastric cancer.Q54709456
Esophageal CancerQ56209683
Barrett's oesophagus is characterized by a predominantly humoral inflammatory responseQ57939544
Significance of HER2 Low-Level Copy Gain in Barrett's Cancer: Implications for Fluorescence In situ Hybridization Testing in TissuesQ60056797
Gains and Amplifications of c-myc, EGFR, and 20.q13 Loci in the No Dysplasia-Dysplasia-Adenocarcinoma Sequence of Barrett's EsophagusQ61814005
Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancerQ69926364
Macrophage infiltrate and prognosis in c-erbB-2-overexpressing breast carcinomasQ70891361
Comparative studies of cardia carcinoma and infracardial gastric carcinomaQ72680677
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)546-554
P577publication date2012-01-01
P1433published inClinical Cancer ResearchQ332253
P1476titleAssociation of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas
P478volume18

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cites work (P2860)
Q36097775A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy
Q47757344A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion
Q58763391A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas
Q38153443Advances in biomarkers for esophageal cancer
Q36910400Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma
Q33709855Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma
Q40619773Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications
Q34852929Association between HSP90 and Her2 in gastric and gastroesophageal carcinomas
Q39114318Bile acid at low pH reduces squamous differentiation and activates EGFR signaling in esophageal squamous cells in 3-D culture
Q39751816Central nervous system relapse in patients with untreated HER2-positive esophageal or gastroesophageal junction adenocarcinoma
Q54501808Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis.
Q36410392Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma.
Q35151182Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies.
Q40107322Digital image analysis of HER2 immunohistochemistry in gastric- and oesophageal adenocarcinoma: a validation study on biopsies and surgical specimens
Q36666667Discordant HER2 expression and response to neoadjuvant chemoradiotherapy in esophagogastric adenocarcinoma.
Q49571137EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas.
Q38392935EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer
Q43712233Effect of HER2 on prognosis and benefit from peri-operative chemotherapy in early oesophago-gastric adenocarcinoma in the MAGIC trial
Q57072196Efficacy and safety of trastuzumab as maintenance or palliative therapy in advanced HER2-positive gastric cancer
Q38284597Emerging mAbs for the treatment of esophagogastric cancer
Q38110962Emerging tyrosine kinase inhibitors for esophageal cancer
Q38968846ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways
Q37328638Expression of Human Epidermal Growth Factor Receptor-2 in Resected Rectal Cancer
Q89391950Gastric cancer
Q36020920HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.
Q37599574HER-2/neu gene amplification in relation to expression of HER2 and HER3 proteins in patients with esophageal adenocarcinoma
Q89879114HER2 Heterogeneity in Personalized Therapy of Gastro-Oesophageal Malignancies: An Overview by Different Methodologies
Q28078111HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists
Q41839228HER2 gene amplification in esophageal squamous cell carcinoma is less than in gastroesophageal junction and gastric adenocarcinoma
Q26741253HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice
Q53657591HER2 positivity in gastric and esophageal adenocarcinoma: clinicopathological analysis and comparison.
Q30837184HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer
Q37522215HER2 status in Barrett's esophagus & esophageal cancer: a meta analysis
Q90242172HER2-targeted therapies - a role beyond breast cancer
Q60915393HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma
Q42936269Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus
Q55014435Her-2 Expression in Gastroesophageal Intestinal Metaplasia, Dysplasia, and Adenocarcinoma.
Q34223494Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications
Q51103473Human epidermal growth factor receptor 2 overexpression and amplification in endoscopic biopsies and resection specimens in esophageal and junctional adenocarcinoma.
Q39069439Human epidermal growth factor receptor 2 status of gastric cancer patients in Asia: results from a large, multicountry study
Q34559419Human epidermal growth factor receptor 2 testing in gastric cancer: recommendations of an Asia-Pacific task force
Q35051918Human epidermal growth factor receptor-2 expression in locally advanced rectal cancer: association with response to neoadjuvant therapy and prognosis
Q90271677Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma
Q38316610Introducing biomarker panel in esophageal, gastric, and colon cancers; a proteomic approach
Q99565418Investigation of HER-2 Expression an Its Correlation with Clinicopathological Parameters and Overall Survival of Esophageal Squamous Cell Carcinoma Patients
Q40571939Lipase member H frequently overexpressed in human esophageal adenocarcinomas
Q34820809MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer.
Q47967299Met, IGF1R, and other new targets in upper GI malignancies
Q33750142Multi-colour FISH in oesophageal adenocarcinoma-predictors of prognosis independent of stage and grade
Q58783978New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment
Q38653309Pertuzumab in gastrointestinal cancer
Q39115912STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.
Q35619400STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells
Q34409666Strategies to improve outcomes in esophageal adenocarcinoma.
Q28085367Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma
Q35037270Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer
Q38254375The potential for targeting HER2 therapeutically in esophageal cancer - a grasp at straws?
Q28069924The promise of PD-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. PD-L1
Q89700506Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer
Q55039208Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression.
Q87376791[Update on Barrett esophagus and Barrett carcinoma]

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