Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications

scientific article published on 16 August 2016

Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10120-016-0625-1
P698PubMed publication ID27530622

P50authorArmando SantoroQ56335956
Riccardo RosatiQ57655362
Marina BarettiQ61151248
Nicola PersoneniQ38524333
Lorenza RimassaQ38524354
P2093author name stringMaria Chiara Tronconi
Uberto Fumagalli Romario
Massimo Roncalli
Laura Giordano
Luca Rubino
Paola Spaggiari
Silvia Bozzarelli
P2860cites workIntratumoral heterogeneity determines discordant results of diagnostic tests for human epidermal growth factor receptor (HER) 2 in gastric cancer specimens.Q54559293
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Combined HER2 analysis of biopsies and surgical specimens to optimize detection of trastuzumab-eligible patients in eso-gastric adenocarcinoma: a GERCOR study.Q54784542
Significance of Histopathological Tumor Regression After Neoadjuvant Chemotherapy in Gastric AdenocarcinomasQ60056779
Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization studyQ80206188
Human epidermal growth factor receptor 2 testing in gastric carcinoma: issues related to heterogeneity in biopsies and resectionsQ82547098
Matched biopsy and resection specimens of gastric and gastroesophageal adenocarcinoma show high concordance in HER2 statusQ87492670
Chemotherapy for advanced gastric cancerQ24236634
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
HER2 testing in gastric cancer: a practical approachQ28256814
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerQ29619394
Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patientsQ33390513
HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient dataQ34019589
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.Q34554455
Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trialQ34627996
Clinicopathologic factors associated with HER2-positive gastric cancer and its impact on survival outcomes--a systematic reviewQ34631121
Gastric cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ34656353
Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but AlsoQ35610564
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomasQ35681702
Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancerQ35809752
Comparison on Clinicopathological Features and Prognosis Between Esophagogastric Junctional Adenocarcinoma (Siewert II/III Types) and Distal Gastric Adenocarcinoma: Retrospective Cohort Study, a Single Institution, High Volume Experience in ChinaQ36153084
Her2/neu testing in gastric cancer: evaluating the risk of sampling errorsQ36615782
Five biopsy specimens from the proximal part of the tumor reliably determine HER2 protein expression status in gastric cancerQ36778082
Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trialQ36950483
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapyQ37180708
Targeting anthracyclines in early breast cancer: new candidate predictive biomarkers emergeQ37777021
Chemotherapy in the treatment of metastatic gastric cancer: is there a global standard?Q37832986
Effect of HER2 on prognosis and benefit from peri-operative chemotherapy in early oesophago-gastric adenocarcinoma in the MAGIC trialQ43712233
Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial.Q44354605
Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines.Q50999355
Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis.Q53128686
Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: Results of GASTric cancer HER2 reassessment study 1 (GASTHER1).Q53179955
Esophageal and esophagogastric junction cancers, version 1.2015.Q53612616
Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer.Q54483761
P433issue3
P921main subjectgastroesophageal adenocarcinomaQ61913383
P304page(s)428-437
P577publication date2016-08-16
P1433published inGastric CancerQ15724608
P1476titleAssessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications
P478volume20

Reverse relations

cites work (P2860)
Q46129222Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.
Q57798725Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma