Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications

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Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2014/852748
P932PMC publication ID4170925
P698PubMed publication ID25276427
P5875ResearchGate publication ID266573809

P2093author name stringNida Iqbal
Naveed Iqbal
P2860cites workUpdate on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family membersQ21195197
A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumabQ24594725
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancerQ27851553
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancerQ27851691
Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
The distinctive nature of HER2-positive breast cancersQ28278028
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
EGF-ERBB signalling: towards the systems levelQ29619032
An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: a Gynecologic Oncology Group study.Q30439393
Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598.Q33359693
Role of HER2 gene overexpression in breast carcinomaQ33810080
Biologic and therapeutic role of HER2 in cancerQ34267775
Development of Herceptin resistance in breast cancer cellsQ34293506
The role of overexpressed HER2 in transformationQ34346141
Lung cancer: intragenic ERBB2 kinase mutations in tumoursQ34354426
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisQ34493341
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancerQ34496969
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.Q34554455
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneQ34560337
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancerQ35583927
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomasQ35681702
The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancerQ36135007
HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladderQ36671182
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancerQ36678853
Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinomaQ36910400
Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell lineQ36911274
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridizationQ37054834
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Expression of c-erbB-2 oncogene product in Barrett's adenocarcinoma: pathological and prognostic correlationsQ37245090
Anti-HER agents in gastric cancer: from bench to bedsideQ37885725
HER-2/neu amplification and overexpression in endometrial carcinoma.Q38468928
Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.Q38485006
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.Q40144433
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.Q40449400
Trastuzumab, paclitaxel, cisplatin, and radiation for adenocarcinoma of the esophagus: a phase I study.Q40463186
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancerQ40544950
The c-erbB-2 protein in oncogenesis: molecular structure to molecular epidemiology.Q40587964
Receptor protein-tyrosine kinases and their signal transduction pathwaysQ40611453
Epidermal growth factor stimulates phosphorylation in membrane preparations in vitroQ40693948
Expression of Her-2/neu in human lung cancer cell lines by immunohistochemistry and fluorescence in situ hybridization and its relationship to in vitro cytotoxicity by trastuzumab and chemotherapeutic agentsQ40775553
Specificity within the EGF family/ErbB receptor family signaling networkQ41721612
HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testingQ42431264
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cellsQ42807469
Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomasQ42825581
Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinomaQ46684059
c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinomaQ47373020
HER-2/neu protein overexpression and gene amplification in human transitional cell carcinoma of the bladderQ47794879
Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancerQ48371008
Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma.Q51056791
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigenQ52827123
HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry.Q53597732
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline updateQ57130157
Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancerQ68090336
Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancerQ68290745
Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomasQ68740689
Lack of expression of c-erbB-2 oncoprotein in human esophageal squamous cell carcinomasQ71159389
Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study GroupQ72234622
Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patientsQ72658430
The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomasQ77386062
NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancerQ77626728
HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptinQ79289949
Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagusQ79401515
Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trialQ80406288
HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patientsQ83367544
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectoverexpressionQ61643320
P304page(s)852748
P577publication date2014-09-07
P1433published inMolecular Biology InternationalQ26841791
P1476titleHuman Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications
P478volume2014

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cites work (P2860)
Q37734452"Targeted" Chemotherapy for Esophageal Cancer
Q89623377'Omics Approaches to Explore the Breast Cancer Landscape
Q101166804A DNA-nanoassembly-based approach to map membrane protein nanoenvironments
Q90117982A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks
Q37694673A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity
Q89172835A pharmacokinetics phase 1 bioequivalence study of the trastuzumab biosimilar MYL-1401O vs. EU-trastuzumab and US-trastuzumab
Q26773907Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer
Q33608593Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes
Q64950548Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer.
Q64124307Advances in bacterial cancer therapies using synthetic biology
Q90029476Alternative ORFs and small ORFs: shedding light on the dark proteome
Q26797471Analysis of different HER-2 mutations in breast cancer progression and drug resistance
Q60924652Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression
Q54252199Antibody response to HER2 extracellular domain and subdomains in mouse following DNA immunization.
Q91845207Assessment of ERBB2 and TOP2α gene status and expression profile in feline mammary tumors: findings and guidelines
Q90247804Assessment of the Molecular Mechanism of Action of SB3, a Trastuzumab Biosimilar
Q37648136Associations between pathologic tumor features and preadjuvant therapy cognitive performance in women diagnosed with breast cancer.
Q38694128BRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model
Q104471894C-demethylation and 1, 2-amino shift in (E)-2-(1-(3-aminophenyl) ethylidene)hydrazinecarboxamide to (E)-2-(2-aminobenzylidene)hydrazinecarboxamide and their applications
Q40903579Change in CD3ζ-chain expression is an independent predictor of disease status in head and neck cancer patients
Q41595482Circulating tumor DNA functions as an alternative for tissue to overcome tumor heterogeneity in advanced gastric cancer
Q58803669Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer
Q92557334Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
Q64076747Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex
Q62495036Current Strategies and Applications for Precision Drug Design
Q45943585Designed Ankyrin Repeat Proteins as Her2 Targeting Domains in Chimeric Antigen Receptor-Engineered T Cells.
Q41661216Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload
Q90473436Development and verification of a three-dimensional (3D) breast cancer tumor model composed of circulating tumor cell (CTC) subsets
Q64955074Differential Effects of Inhibitory and Stimulatory Anti-HER2 Monoclonal Antibodies on AKT/ERK Signaling Pathways
Q92550910Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor
Q36312110Distinct ErbB2 receptor populations differentially interact with beta1 integrin in breast cancer cell models
Q41835996Driving better and safer HER2-specific CARs for cancer therapy
Q93155695Elimination of Osteosarcoma by Necroptosis with Graphene Oxide-Associated Anti-HER2 Antibodies
Q42281218Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers
Q26746909Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy
Q90266694Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7
Q54994574FGFR1 and HER1 or HER2 co-amplification in breast cancer indicate poor prognosis.
Q91980872Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
Q37377544Genetic Heterogeneity of HER2 Amplification and Telomere Shortening in Papillary Thyroid Carcinoma
Q90393213Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
Q64063349HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer
Q47304027HER2 Overexpression in Retinoblastoma: A Potential Therapeutic Target?
Q91728336HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis
Q37269081HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth
Q41934319HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Q47222791Hitting the Target: How T Cells Detect and Eliminate Tumors
Q99408079Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer
Q41660817Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells
Q90211923Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro
Q37045824Human Epidermal Growth Factor Receptor 2 (HER-2/neu)-Directed Therapy for Rare Metastatic Epithelial Tumors with HER-2 Amplification
Q37221158Human epidermal growth factor receptor 2/neu protein expression in meningiomas: An immunohistochemical study
Q37013995Identification of Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma
Q35842236Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role
Q90469063Impact of Molybdenum Compounds as Anticancer Agents
Q42070603Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer
Q55264153Incorporation of p-53 mutation status and Ki-67 proliferating index in classifying Her2-neu positive gastric adenocarcinoma.
Q99565418Investigation of HER-2 Expression an Its Correlation with Clinicopathological Parameters and Overall Survival of Esophageal Squamous Cell Carcinoma Patients
Q30250289Is the false-positive rate in mammography in North America too high?
Q47160829Ki-67 Expression by Immunohistochemistry and Quantitative Real-Time Polymerase Chain Reaction as Predictor of Clinical Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer.
Q38569109Membrane microparticles: shedding new light into cancer cell communication.
Q49375694Molecular pathological predictive diagnostics in a patient with non-small cell lung cancer treated with crizotinib therapy: A case report
Q92890127NDRG1 suppresses vasculogenic mimicry and tumor aggressiveness in gastric carcinoma
Q98167111Nanoparticulate RNA delivery systems in cancer
Q50201250Neratinib: First Global Approval
Q47221234New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness
Q48924057Non-fluorescent quantification of single mRNA with transient absorption microscopy.
Q92384079Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer
Q38845078Oncolytic potency of HER-2 retargeted VSV-FH hybrid viruses: the role of receptor ligand affinity
Q89622510Ovarian Cancer Targeted Theranostics
Q47281580Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?
Q90482989Overcome trastuzumab resistance of breast cancer using anti-HER2 chimeric antigen receptor T cells and PD1 blockade
Q100490609Overview of current targeted therapy in gallbladder cancer
Q90987627PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers
Q36295013PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas
Q98177661Peptide Vaccine Combined Adjuvants Modulate Anti-tumor Effects of Radiation in Glioblastoma Mouse Model
Q61810424Phase 3 LILAC study sets standard for clinical evaluation of oncology biosimilars
Q36344901Polymeric oncolytic adenovirus for cancer gene therapy
Q26775315Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives
Q55175195Prevalence of HER2 Positivity and Its Clinicopathological Correlation in Locally Advanced/Metastatic Gastric Cancer Patients in Malaysia.
Q97094411Producing defucosylated antibodies with enhanced in vitro antibody-dependent cellular cytotoxicity via FUT8 knockout CHO-S cells
Q91984696Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation
Q58601833Prognostic value of ErbB2/HER2 in human meningiomas
Q64891425Proteasome 26S Subunit, non-ATPase 3 (PSMD3) Regulates Breast Cancer by Stabilizing HER2 from Degradation.
Q40975738Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Q64056483Pyrotinib treatment on HER2-positive gastric cancer cells promotes the released exosomes to enhance endothelial cell progression, which can be counteracted by apatinib
Q36583265Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy.
Q57162471RAS-expanded Mutations and HER2 Expression in Metastatic Colorectal Cancer: A New Step of Precision Medicine
Q89541984Radiosensitization of HER2-positive esophageal cancer cells by pyrotinib
Q38662712Review: circulating tumor cells in the practice of breast cancer oncology.
Q38704805SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression
Q64288884Screening of potential phytocompounds from Euclea crispa (Thunb.) leaves targeting human epidermal growth factor receptor 2 (HER2) signaling pathway
Q97094559Silica-based organic-inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery
Q57477210Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2
Q51708755Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.
Q91637215Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer
Q58798280Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody
Q48042475Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants
Q93006248Structure-Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy
Q52346962Study of Interactions of an Anticancer Drug Neratinib With Bovine Serum Albumin: Spectroscopic and Molecular Docking Approach.
Q30835291Superresolution Imaging of Clinical Formalin Fixed Paraffin Embedded Breast Cancer with Single Molecule Localization Microscopy
Q47190264Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review
Q33822560Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines
Q96950520Systems biology comprehensive analysis on breast cancer for identification of key gene modules and genes associated with TNM-based clinical stages
Q55210424Target-specific delivery of oxaliplatin to HER2-positive gastric cancer cells in vivo using oxaliplatin-au-fe3o4-herceptin nanoparticles.
Q26781278Targeting RTK Signaling Pathways in Cancer
Q91634586Targeting fusions for improved outcomes in oncology treatment
Q39390640Targeting the mTOR pathway in breast cancer
Q47411655The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
Q35687706The Clinicopathologic and Prognostic Value of Altered Chromosome 17 Centromere Copy Number in HER2 Fish Equivocal Breast Carcinomas
Q95841155The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review
Q47167746The crossroads of breast cancer progression: insights into the modulation of major signaling pathways
Q49887908The role of RICTOR downstream of receptor tyrosine kinase in cancers.
Q95661084The strategic combination of trastuzumab emtansine with oncolytic rhabdoviruses leads to therapeutic synergy
Q89700506Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer
Q93167098Triggered Immune Response Induced by Antigenic Epitopes Covalently Linked with Immunoadjuvant-Pulsed Dendritic Cells as a Promising Cancer Vaccine
Q28069898Tumour biomarkers: homeostasis as a novel prognostic indicator
Q37743486mTOR function and therapeutic targeting in breast cancer