BRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model

scientific article

BRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.22034/APJCP.2017.18.8.2209
P932PMC publication ID5697482
P698PubMed publication ID28843257

P2093author name stringSatyajit Patra
Vanesa Young
Jesil Mathew
Jitendra N Senapati
Leslie Llewellyn
P2860cites workPI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerQ24338724
Comprehensive molecular portraits of human breast tumoursQ24630844
Neoadjuvant therapy of early stage human epidermal growth factor receptor 2 positive breast cancer: latest evidence and clinical implicationsQ27001729
Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor designQ27729300
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicQ27824826
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.Q27851582
Cancer statistics, 2016Q29547383
The clonal and mutational evolution spectrum of primary triple-negative breast cancersQ29619914
Trastuzumab emtansine: mechanisms of action and drug resistanceQ33759627
Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic interventionQ34103963
Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic ImplicationsQ34223494
HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug developmentQ34499609
Personalized drug combinations to overcome trastuzumab resistance in HER2-positive breast cancerQ34664129
Spectrum of EGFR gene copy number changes and KRAS gene mutation status in Korean triple negative breast cancer patientsQ35036895
Intrinsic subtypes, PIK3CA mutation, and the degree of benefit from adjuvant trastuzumab in the NSABP B-31 trialQ35419840
The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer--a systematic reviewQ36294151
Optimal targeting of HER2-PI3K signaling in breast cancer: mechanistic insights and clinical implicationsQ36986099
Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancerQ37145885
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapyQ37163797
Antibody-based therapy for solid tumorsQ37184302
Mechanisms of Adipocytokine-Mediated Trastuzumab Resistance in HER2-Positive Breast Cancer Cell LinesQ37263096
ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation.Q37317337
Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancerQ37317395
Predicting degree of benefit from adjuvant trastuzumab in NSABP trial B-31.Q37360367
PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancerQ37380424
Outcome of patients with HER2-positive breast cancer treated with or without adjuvant trastuzumab in the Finland Capecitabine Trial (FinXX).Q37489864
Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor activity in HER2+ breast cancer cellsQ37690005
Molecular determinants of trastuzumab efficacy: What is their clinical relevance?Q38096651
Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer.Q38238740
Pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancerQ38286163
The role of p95HER2 in trastuzumab resistance in breast cancerQ38379899
Gamma-irradiation induces HER-2/neu overexpression in breast cancer cell lines and sensitivity to treatment with trastuzumabQ39212216
The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell LinesQ39669204
Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.Q39771406
Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer.Q45945230
Phase Ib study of Buparlisib plus Trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on Trastuzumab-based therapyQ87177751
P433issue8
P921main subjecttrastuzumabQ412616
cancer cell lineQ23058136
P304page(s)2209-2213
P577publication date2017-08-27
P1433published inAsian Pacific Journal of Cancer PreventionQ15759519
P1476titleBRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model
P478volume18

Reverse relations

cites work (P2860)
Q53686361LMO4 mediates trastuzumab resistance in HER2 positive breast cancer cells.
Q61447406Silencing the Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt

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