PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas

scientific article

PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1007306347
P356DOI10.1038/BJC.2015.306
P932PMC publication ID4651122
P698PubMed publication ID26325104
P5875ResearchGate publication ID281520847

P50authorSalvatore LopezQ43122922
Elena BonazzoliQ85217898
P2093author name stringAlessandro D Santin
Stefania Bellone
Peter E Schwartz
Emiliano Cocco
Elena Ratner
Dan-Arin Silasi
Masoud Azodi
Carlton L Schwab
Diana P English
Jonathan D Black
Federica Predolini
Francesca Ferrari
Gary Altwerger
P2860cites workHER2 expression beyond breast cancer: therapeutic implications for gynecologic malignanciesQ26822730
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingQ27851446
Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group studyQ27851528
Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo.Q27853078
Cancer statistics, 2015Q27860576
Integrated genomic characterization of endometrial carcinomaQ28289962
HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic ChallengesQ28308118
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cellsQ33564297
Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic ImplicationsQ34223494
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancersQ34497057
A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomasQ34694344
Two pathogenetic types of endometrial carcinomaQ34713298
T-DM1, a novel antibody-drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivoQ34998509
Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumabQ35527141
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genesQ36447819
Therapeutic targets: MTOR and related pathwaysQ36592032
Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?Q36613598
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinomaQ36637663
Surgical management and adjuvant therapy for patients with uterine clear cell carcinoma: a multi-institutional reviewQ37039136
Targeting the human EGFR family in esophagogastric cancerQ37862077
HER2/neu gene amplification determines the sensitivity of uterine serous carcinoma cell lines to AZD8055, a novel dual mTORC1/2 inhibitor.Q39098938
Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).Q39119683
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinibQ39700483
Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell linesQ39820639
The biology of erbB-2/neu/HER-2 and its role in cancerQ40567924
NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancerQ41925146
Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage diseaseQ44617061
Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinomaQ46684059
Analysis of HER-2/neu amplification in endometrial carcinoma by chromogenic in situ hybridization. Correlation with fluorescence in situ hybridization, HER-2/neu, p53 and Ki-67 protein expression, and outcomeQ47231231
HER-2/neu overexpression in uterine papillary serous cancers and its possible therapeutic implications.Q53587822
Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2Q62604209
Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancerQ68090336
The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavageQ72235719
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cellsQ74650838
Uterine papillary serous carcinoma: what have we learned over the past quarter century?Q81088714
HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patientsQ83367544
Para-aortic lymphadenectomy in the management of preoperative grade 1 endometrial cancer confined to the uterine corpusQ84495683
P4510describes a project that usesUSPC-ARK-1Q54991940
USPC-ARK-2Q54991963
USPC-ARK-20Q54991965
USPC-ARK-21Q54991967
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
cell lineQ21014462
overexpressionQ61643320
P304page(s)1020-1026
P577publication date2015-09-01
P1433published inBritish Journal of CancerQ326309
P1476titlePIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.
P478volume113

Reverse relations

described by source (P1343)
Q54991940USPC-ARK-1
Q54991963USPC-ARK-2
Q54991965USPC-ARK-20
Q54991967USPC-ARK-21

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Q37644791Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
Q37551185Effect of Fu-Zheng-Xiao-Liu Granules on Expression of Human Epidermal Growth Factor Receptor 2 (HER-2) and Proliferation and Apoptosis of Breast Cancer Cell Line SKBR-3.
Q91906091Efficacy of afatinib in a HER2 amplification-positive endometrioid adenocarcinoma patient- a case report
Q38598081Emerging strategies for targeting PI3K in gynecologic cancer
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Q90987627PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers
Q92864431PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer
Q37696147Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells
Q61447406Silencing the Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt
Q38680412Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression
Q57169683Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late
Q55435506The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment.

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