A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

scientific article published on 05 October 2016

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.12480
P932PMC publication ID5346661
P698PubMed publication ID27713176

P2093author name stringCarol A Lange
Benjamin E Rich
David J Burns
Sara A Hurvitz
Yao Huang
Leo T Furcht
Brian F Sullivan
Abhijit Dandapat
Ian A MacNeil
Lance G Laing
Sajjad M Soltani
Samantha Myhre
P2860cites workThe ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
Activating HER2 mutations in HER2 gene amplification negative breast cancerQ27851987
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effectsQ28678663
Label-free and real-time cell-based kinase assay for screening selective and potent receptor tyrosine kinase inhibitors using microelectronic sensor arrayQ33251283
Discovery and validation of breast cancer subtypesQ33257139
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based reviewQ33561966
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studiesQ33593016
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activationQ33733313
Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic ImplicationsQ34223494
Targeting HER2 in other tumor typesQ34346131
Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mappingQ34436356
Label-Free Receptor AssaysQ34473007
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinaseQ34720797
Assessment of HER2 status in breast cancer: overall positivity rate and accuracy by fluorescence in situ hybridization and immunohistochemistry in a single institution over 12 years: a quality control studyQ35078787
The significance of HER-2/neu receptor positivity and immunophenotype in ductal carcinoma in situ with early invasive diseaseQ35201328
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family BromodomainsQ35533503
HER Targeting in HER2-Negative Breast Cancers: Looking for the HER3 PositiveQ35812023
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancerQ35895370
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Q36221780
Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cellsQ36311216
The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicineQ37433324
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.Q37523202
Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation.Q37568043
Bistability in one equation or fewerQ38077718
HER2 testing: current status and future directions.Q38147681
Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancerQ38463900
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast CancerQ38888022
Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients.Q39742222
Serum-free solutions for cryopreservation of cellsQ40078788
Strategies for cell permeabilization and fixation in detecting surface and intracellular antigensQ40844876
Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapyQ42025768
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersQ42457867
HER3 overexpression and survival in solid tumors: a meta-analysisQ43659959
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growthQ44120544
mRNA in situ hybridization (HistoSonda): a new diagnostic tool for HER2-status in breast cancer-a multicentric Spanish study.Q44383595
High concordance between HercepTest immunohistochemistry and ERBB2 fluorescence in situ hybridization before and after implementation of American Society of Clinical Oncology/College of American Pathology 2007 guidelinesQ46452729
Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancerQ46701849
Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapiesQ48205560
HER3 status by immunohistochemistry is correlated with poor prognosis in hormone receptor-negative breast cancer patients.Q50949577
Evaluation of HER2/neu Status by Immunohistochemistry Using Computer-Based Image Analysis and Correlation With Gene Amplification by Fluorescence In Situ Hybridization Assay: A 10-Year Experience and Impact of Test Standardization on Concordance RatQ55054330
Reconstruction of human mammary tissues in a mouse modelQ80092812
HER2 status and benefit from adjuvant trastuzumab in breast cancerQ80959592
Prognostic relevance of gene amplifications and coamplifications in breast cancerQ81085059
Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patientsQ81414756
P433issue48
P407language of work or nameEnglishQ1860
P304page(s)78577-78590
P577publication date2016-10-05
P1433published inOncotargetQ1573155
P1476titleA functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity
P478volume7

Reverse relations

Q89612527New HER2-negative breast cancer subtype responsive to anti-HER2 therapy identifiedcites workP2860

Search more.