Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

scientific article published on 25 August 2017

Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS18091860
P932PMC publication ID5618509
P698PubMed publication ID28841157

P2093author name stringYanming Wang
Song Li
Wu Zhong
Xinbo Zhou
Shiyong Fan
P2860cites workSGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.Q50904360
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Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cellsQ28201813
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Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinomaQ37606966
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HER2-targeted antibody drug conjugates for ovarian cancer therapyQ38752699
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Development and properties of beta-glucuronide linkers for monoclonal antibody-drug conjugatesQ40279317
Dipeptide-based highly potent doxorubicin antibody conjugatesQ40353611
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): a phase 3, randomised, double-blind, multicentre trial.Q41655720
Efficient elimination of CD103-expressing cells by anti-CD103 antibody drug conjugates in immunocompetent miceQ41735350
Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activityQ44066317
HER2 aberrations in cancer: implications for therapyQ44936056
Micro- and mid-scale maleimide-based conjugation of cytotoxic drugs to antibody hinge region thiols for tumor targetingQ45244928
Cathepsin B Cleavage of vcMMAE-Based Antibody-Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier SpecificQ46596240
Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer PayloadQ47139670
Drug-to-antibody ratio (DAR) and drug load distribution by hydrophobic interaction chromatography and reversed phase high-performance liquid chromatographyQ47864055
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P577publication date2017-08-25
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleDevelopment and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload
P478volume18

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cites work (P2860)
Q92040902An FDA oncology analysis of toxicities associated with PBD-containing antibody-drug conjugates
Q47103332Development and clinical application of anti-HER2 monoclonal and bispecific antibodies for cancer treatment
Q64072797Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy
Q91747362Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy
Q92165417Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3

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