Digital image analysis of HER2 immunohistochemistry in gastric- and oesophageal adenocarcinoma: a validation study on biopsies and surgical specimens

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Digital image analysis of HER2 immunohistochemistry in gastric- and oesophageal adenocarcinoma: a validation study on biopsies and surgical specimens is …
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scholarly articleQ13442814

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P356DOI10.1111/HIS.13322
P698PubMed publication ID28746978

P50authorGeertruida H de BockQ37842361
Bert van der VegtQ50889999
P2093author name stringAlex L T Imholz
Henk J Buikema
Maarten Louwen
Maria M Smits
Mariska Hage
Timco Koopman
P2860cites workThe Measurement of Observer Agreement for Categorical DataQ26778373
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
HER2 testing in gastric cancer: a practical approachQ28256814
Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalitiesQ33612658
HER2 amplification in gastroesophageal adenocarcinoma: correlation of two antibodies using gastric cancer scoring criteria, H score, and digital image analysis with fluorescence in situ hybridizationQ33863322
Image analysis as an adjunct to manual HER-2 immunohistochemical review: a diagnostic tool to standardize interpretationQ34044859
HER2 in gastric cancer: a digital image analysis in pre-neoplastic, primary and metastatic lesions.Q34324291
Updated UK Recommendations for HER2 assessment in breast cancerQ35048548
HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma.Q35111575
Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarraysQ35318918
Optimizing HER2 assessment in breast cancer: application of automated image analysisQ35673706
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomasQ35681702
Human epidermal growth factor receptor 2 (HER2) immunoreactivity: specificity of three pharmacodiagnostic antibodiesQ35686959
Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemopreventionQ36120729
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Quantitation of HER2/neu expression in primary gastroesophageal adenocarcinomas using conventional light microscopy and quantitative image analysisQ37251780
Comparing subjective and digital image analysis HER2/neu expression scores with conventional and modified FISH scores in breast cancerQ39792766
Digital image analysis of membrane connectivity is a robust measure of HER2 immunostainsQ39980300
Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinomaQ40217601
Free digital image analysis software helps to resolve equivocal scores in HER2 immunohistochemistryQ40324533
HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testingQ42431264
Image cytometric HER2 in gastric carcinoma: is a new algorithm needed?Q44196543
Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis.Q53128686
Pathologic diagnostics of HER2 positivity in gastroesophageal adenocarcinoma.Q53163402
Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.Q53252056
HER2 positivity in gastric and esophageal adenocarcinoma: clinicopathological analysis and comparison.Q53657591
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline updateQ57130157
P433issue2
P921main subjectbiopsyQ179991
adenocarcinomaQ356033
immunohistochemistryQ899285
P304page(s)191-200
P577publication date2017-07-26
P1433published inHistopathologyQ1524040
P1476titleDigital image analysis of HER2 immunohistochemistry in gastric- and oesophageal adenocarcinoma: a validation study on biopsies and surgical specimens
P478volume72

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cites work (P2860)
Q90178792A Validation Study of Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Digital Imaging Analysis and its Correlation with Human Epidermal Growth Factor Receptor 2 Fluorescence In situ Hybridization Results in Breast Carcinoma
Q57822882Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma