PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

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PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1085558737
P356DOI10.1186/S12943-017-0660-5
P932PMC publication ID5441085
P698PubMed publication ID28532501

P50authorRoch-Philippe CharlesQ38642441
Michaela MedováQ81652681
P2093author name stringRoland Giger
Yitzhak Zimmer
Michaela Poliaková
Daniel Matthias Aebersold
Paola Francica
Lluís Nisa
Pascal Häfliger
P2860cites workmTOR signaling in growth control and diseaseQ24634174
Met in urological cancersQ26864988
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KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.Q27851616
Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrenceQ27851725
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkersQ27852227
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitorsQ27853166
The phosphoinositide 3-kinase pathwayQ27860738
Mapping the Pathways of Resistance to Targeted TherapiesQ28088791
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variantsQ28254690
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancerQ28298328
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101Q28678835
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
PI3K and cancer: lessons, challenges and opportunitiesQ30080017
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaQ30494514
Prognostic and predictive significance of MYC and KRAS alterations in breast cancer from women treated with neoadjuvant chemotherapyQ31114634
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumorsQ33929301
mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutationsQ34049613
MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesotheliomaQ34182679
Cabozantinib in progressive medullary thyroid cancerQ34185084
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cellsQ34234737
HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancerQ35174872
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targetingQ35260766
Retrospective Review of MET Gene MutationsQ35745037
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profilingQ36288956
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibitionQ36868012
Targeting the human epidermal growth factor receptor 2 (HER2) in the treatment of breast cancer: recent advances and future directionsQ37161255
Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R.Q37275769
Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.Q37301530
The role of EGFR inhibition in the treatment of non-small cell lung cancerQ37628306
Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancerQ37817718
Targeting MET in cancer: rationale and progressQ37978193
MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedsideQ38132874
Targeting the MET gene for the treatment of non-small-cell lung cancerQ38172700
The Met receptor tyrosine kinase: a key player in oncogenesis and drug resistanceQ38175267
KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.Q38880117
PIK3CA mutations in head and neck squamous cell carcinomaQ40305620
Mutant PIK3CA promotes cell growth and invasion of human cancer cellsQ40410776
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.Q40453775
A New Drug Combinatory Effect Prediction Algorithm on the Cancer Cell Based on Gene Expression and Dose-Response CurveQ40678957
New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitorsQ41127315
Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.Q42506362
The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants.Q42812957
Differential inhibition sensitivities of MET mutants to the small molecule inhibitor SU11274.Q42833570
Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinibQ45265090
Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family functionQ73759958
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of headQ86035602
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)93
P577publication date2017-05-22
P1433published inMolecular CancerQ15724585
P1476titlePIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models
P478volume16

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cites work (P2860)
Q47162757Actionable mutations in canine hemangiosarcoma.
Q64926935Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer.
Q64238086Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma
Q64967099POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
Q58566840The Role of PI3K in Met Driven Cancer: A Recap

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