The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma

scientific article

The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-08-2881
P8608Fatcat IDrelease_agsag5phrjbovkzgflifcu2wai
P932PMC publication ID2871252
P698PubMed publication ID19318576

P50authorEverett E VokesQ73567428
Ravi SalgiaQ73567837
Tanguy Y SeiwertQ89776148
Mark W. LingenQ113027272
Rajani KantetiQ113027596
Ezra E CohenQ38641744
P2093author name stringLeslie Martin
James G Christensen
Leonardo Faoro
Soheil Yala
Soundararajan Krishnaswamy
Ramasamy Jagadeeswaran
Andres Klein-Szanto
Vidya Nallasura
Mohamed El Dinali
Varalakshmi Janamanchi
P2860cites workAmplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752Q24541450
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinibQ24646295
Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.Q54017063
Open-Label, Uncontrolled, Multicenter Phase II Study to Evaluate the Efficacy and Toxicity of Cetuximab As a Single Agent in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Who Failed to Respond to Platinum-BaseQ57949385
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expressionQ59565588
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomasQ73586595
Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastasesQ73911408
Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significanceQ74287365
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Cancer statistics, 2008Q27860585
c-Met: structure, functions and potential for therapeutic inhibitionQ28190143
Targeting the c-Met signaling pathway in cancerQ28246393
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variantsQ28254690
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasionQ28263339
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survivalQ28282398
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
Platinum-based chemotherapy plus cetuximab in head and neck cancerQ33381094
Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samplesQ33950256
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinaseQ34263863
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissuesQ35575126
Signaling networks assembled by oncogenic EGFR and c-MetQ36392991
Activating mutations for the met tyrosine kinase receptor in human cancerQ36595980
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesisQ36601812
Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.Q36882696
The role of phosphoinositide 3-kinase pathway inhibitors in the treatment of lung cancerQ36899915
Expression and mutational analysis of MET in human solid cancersQ36975055
Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynxQ38450015
Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinomaQ38512195
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenograftsQ40144642
Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesotheliomaQ40333091
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.Q40453775
Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion.Q40514504
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functionsQ40626106
SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.Q40749632
Scatter factor expression and regulation in human glial tumorsQ41184022
MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.Q43827034
Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factorQ45143177
Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR.Q46813416
Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neckQ47257497
c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastasesQ47349579
Scatter factor receptor (c-Met) as possible prognostic factor in patients with oral squamous cell carcinoma.Q47576232
Expression of hepatocyte growth factor and c-met protein is significantly associated with the progression of oral squamous cell carcinoma in Taiwan.Q47828818
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.Q53479014
Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients.Q53875696
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecthead and neck squamous cell carcinomaQ18348812
P304page(s)3021-3031
P577publication date2009-03-24
P1433published inCancer ResearchQ326097
P1476titleThe MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
P478volume69

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