Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.

scientific article

Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/1097-0215(20010220)96:1<41::AID-IJC5>3.0.CO;2-F
P698PubMed publication ID11241329

P2093author name stringD M Aebersold
R H Greiner
A Kollar
J Laissue
K T Beer
V Djonov
P2860cites workIdentification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondriaQ24311858
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complexQ28263687
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activityQ28306175
The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosisQ28611462
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Signal transduction and cellular radiation responsesQ33835066
Scatter factor induces blood vessel formation in vivoQ36141804
Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL-2-mediated neovascularizationQ36642174
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factorQ36705281
Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.Q41037685
EGF receptor phosphorylation is affected by ionizing radiationQ41079746
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells.Q41256548
The proto-oncogene Bcl-2 and its role in regulating apoptosisQ41492030
Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.Q41559408
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptorQ41879451
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
Tyrosine kinase receptor indistinguishable from the c-met proteinQ42814654
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Q42991716
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytesQ44192187
Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.MikoQ44863595
Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cellsQ45889537
The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiationQ46204815
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agentsQ47801960
Hepatocyte growth factor protects renal epithelial cells from apoptotic cell deathQ47999769
Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck.Q52533610
bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer.Q52922659
Cumulative prognostic value of p53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy.Q54072035
Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapyQ62690767
Bcl-2 overexpression and smoking history in head and neck cancerQ71943991
bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cellsQ73074287
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damageQ73316771
Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cellsQ73536153
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomasQ73586595
Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neckQ73779194
The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinaseQ73816403
Influence of p53 and bcl-2 on proliferative activity and treatment outcome in head and neck cancer patientsQ73979637
Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynxQ74107308
Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factorQ74424215
Bcl-2 expression correlates with apoptosis induction but not loss of clonogenic survival in small cell lung cancer cell lines treated with etoposideQ77639789
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)41-54
P577publication date2001-02-01
P1433published inInternational Journal of CancerQ332492
P1476titleInvolvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.
P478volume96

Reverse relations

cites work (P2860)
Q92821373Adaptive Responses to Monotherapy in Head and Neck Cancer: Interventions for Rationale-Based Therapeutic Combinations
Q35567264Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
Q37349935Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma
Q39838383Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis
Q49414583Clinicopathological impacts of high c-Met expression in head and neck squamous cell carcinoma: a meta-analysis and review
Q34707942Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression
Q28534291Control of cellular Bcl-xL levels by deamidation-regulated degradation
Q37694026Effect of PF-02341066 and radiation on non-small cell lung cancer cells.
Q37746309Epstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma.
Q35174872HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
Q38883827HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.
Q33607965Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment
Q55470167In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides.
Q34972637MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest
Q37490555MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma
Q38956316MET overexpression and gene amplification in NSCLC: a clinical perspective.
Q37392930Met and its ligand HGF are associated with clinical outcome in breast cancer
Q47281319Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor
Q36828371Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy
Q38118439Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibition
Q38602875Outcomes in Advanced Head and Neck Cancer Treated with Up-front Neck Dissection prior to (Chemo)Radiotherapy
Q51755668P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis.
Q38869428Personalized Radiation Oncology: Epidermal Growth Factor Receptor and Other Receptor Tyrosine Kinase Inhibitors
Q38045266Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: systematic review and meta-analysis.
Q55717696Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis.
Q40086138Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines
Q30971455Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family
Q64244272Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma
Q91306867Role of c-Met expression on prognosis of head and neck cancer: A literature review and meta-analysis
Q38167258Role of met axis in head and neck cancer
Q92258309Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma
Q26866936Targeting the Bcl-2 family for cancer therapy
Q37331862Targeting the Met signaling pathway in renal cancer.
Q30494514The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
Q35078950The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response-Biological and Clinical Aspects
Q48635543The clinical value of serum hepatocyte growth factor levels in patients undergoing primary radiotherapy for glioma: effect on progression-free survival
Q36720868The concurrent chemoradiation paradigm--general principles

Search more.