Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment

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Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment is …
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scholarly articleQ13442814

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P356DOI10.3390/CANCERS9040039
P932PMC publication ID5406714
P698PubMed publication ID28441771

P2093author name stringLaura P Stabile
Natalie J Rothenberger
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Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cellsQ28140678
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cellsQ28143877
Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomasQ28182566
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Met, metastasis, motility and moreQ28235183
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Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinomaQ34085434
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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic MiceQ34627751
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c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptaseQ34883707
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of SnailQ34972866
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Epidemiology, staging, and screening of head and neck cancer.Q35078962
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cellsQ35110418
HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancerQ35174872
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Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancerQ36005545
E-cadherin expression and prognosis of head and neck squamous cell carcinoma: evidence from 19 published investigationsQ36027644
Prognostic value of c-Met expression in oral squamous cell carcinomaQ36375213
c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-MetQ36545205
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Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factorQ36705281
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A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular binsQ37139435
MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinomaQ37490555
Alteration status and prognostic value of MET in head and neck squamous cell carcinomaQ37514050
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The role of human papillomavirus infection in head and neck cancers.Q37799932
Novel therapeutic target for head and neck squamous cell carcinoma: HGF-MET signaling pathwayQ37895099
Overcoming resistance to EGFR inhibitor in head and neck cancer: a review of the literatureQ38030130
Focus on the potential role of ficlatuzumab in the treatment of non-small cell lung cancerQ38089600
Biological, diagnostic and therapeutic relevance of the MET receptor signaling in head and neck cancer.Q38208571
The role of the PD-L1:PD-1 pathway in squamous cell carcinoma of the head and neckQ38211236
Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinomaQ38322099
c-Met expression is a marker of poor prognosis in patients with locally advanced head and neck squamous cell carcinoma treated with chemoradiation.Q38392890
Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynxQ38450015
Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinomaQ38512195
Systemic Therapy for Metastatic or Recurrent Squamous Cell Carcinoma of the Head and NeckQ38544333
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease StudyQ38787080
Mitigation of Tumor-Associated Fibroblast-Facilitated Head and Neck Cancer Progression With Anti-Hepatocyte Growth Factor Antibody Ficlatuzumab.Q38821826
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trialQ38849759
HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.Q38883827
Tivantinib (ARQ-197) exhibits anti-tumor activity with down-regulation of FAK in oral squamous cell carcinomaQ38916240
LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growthQ38955519
Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell linesQ38956071
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.Q38959172
Cancer Statistics, 2017.Q39038674
Preclinical models in HNSCC: A comprehensive reviewQ39097398
EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomasQ39111192
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HGF-MET cascade, a key target for inhibiting cancer metastasis: the impact of NK4 discovery on cancer biology and therapeuticsQ39214964
EMT and tumor metastasisQ39216425
Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.Q39442106
Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulationQ39566894
Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions.Q39674871
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.Q39702478
Novel xenograft model expressing human hepatocyte growth factor shows ligand-dependent growth of c-Met-expressing tumorsQ40146257
Change of E-cadherin by hepatocyte growth factor and effects on the prognosis of hypopharyngeal carcinomaQ40172206
Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusionQ40698534
An orthotopic nude mouse model of oral tongue squamous cell carcinoma.Q40756187
Roles of HGF as a pleiotropic factor in organ regeneration.Q40870023
Three-dimensional cell cultures: from molecular mechanisms to clinical applicationsQ41633372
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjecthead and neck cancerQ1783924
head and neck carcinomaQ18554836
neck cancerQ18966654
P577publication date2017-04-24
P1433published inCancersQ27722963
P1476titleHepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment
P478volume9

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cites work (P2860)
Q64086042Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives
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