Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups.

scientific article published on 11 May 2016

Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES21050612
P932PMC publication ID6272887
P698PubMed publication ID27187326

P2093author name stringJian Huang
Ke Zhang
Lixia Chen
Jinhui Wang
Guihua Wang
Suyu Gao
Yingnan Jiang
P2860cites workDiscovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.Q54333619
The anti-angiogenic and anti-tumor activity of synthetic phenylpropenone derivatives is mediated through the inhibition of receptor tyrosine kinases.Q54540532
Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors.Q55073600
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptorQ24294589
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptorQ24564783
Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformationsQ27660113
Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitorsQ27687506
Development and testing of a general amber force fieldQ29547642
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkitQ29615867
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaQ30494514
BAY 43-9006: preclinical dataQ30736965
Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory ActivitiesQ33636098
Development of c-MET pathway inhibitorsQ34198905
Scatter-factor and semaphorin receptors: cell signalling for invasive growthQ34632043
Drug development of MET inhibitors: targeting oncogene addiction and expedienceQ34782774
From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancerQ34939284
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activityQ34959266
Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signalingQ36020888
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cellsQ36236279
Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitorsQ36723753
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repairQ37357884
Multi-targeted tyrosine kinase inhibitors in clinical development: focus on XL-184 (cabozantinib).Q37965292
Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitorsQ39028418
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agentsQ39196016
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.Q39399221
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.Q39641906
BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ringQ39741030
N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinasesQ39777862
Met gene copy number predicts the prognosis for completely resected non-small cell lung cancerQ39911616
The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair.Q44812445
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P577publication date2016-05-11
P1433published inMoleculesQ151332
P1476titleDiscovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups
P478volume21

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cites work (P2860)
Q52607160Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
Q90748947Synthesis and Antibacterial Activities of Different Five-Membered Heterocyclic Rings Incorporated with Pyridothienopyrimidine

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