review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1517/13543784.2011.600687 |
P698 | PubMed publication ID | 21740293 |
P2093 | author name string | Xiangdong Liu | |
Peggy A Scherle | |||
Robert C Newton | |||
P2860 | cites work | Molecular cloning and expression of human hepatocyte growth factor | Q24305558 |
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis | Q24683896 | ||
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily | Q27654013 | ||
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo | Q27658318 | ||
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling | Q27851406 | ||
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer | Q27851588 | ||
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors | Q27851633 | ||
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis | Q28139783 | ||
Met, metastasis, motility and more | Q28235183 | ||
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family | Q28285975 | ||
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis | Q28295920 | ||
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor | Q28307227 | ||
Scatter factor/hepatocyte growth factor is essential for liver development | Q28504542 | ||
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud | Q28506228 | ||
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses | Q28513246 | ||
Epidermal growth factor receptor mutations in lung cancer | Q29615474 | ||
Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells | Q33922202 | ||
c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention | Q34422211 | ||
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. | Q34454578 | ||
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms | Q34625881 | ||
Drug development of MET inhibitors: targeting oncogene addiction and expedience | Q34782774 | ||
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases | Q35199181 | ||
Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation | Q35277738 | ||
Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells | Q36090650 | ||
Signaling networks assembled by oncogenic EGFR and c-Met | Q36392991 | ||
RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors | Q36540061 | ||
The mutationally activated Met receptor mediates motility and metastasis | Q36735738 | ||
Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia | Q36988579 | ||
Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer | Q37111358 | ||
Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells | Q37141943 | ||
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer | Q37293236 | ||
Novel therapeutic inhibitors of the c-Met signaling pathway in cancer | Q37422804 | ||
Molecularly targeted therapies for thyroid cancers. | Q37527371 | ||
Clinical implications of MET gene copy number in lung cancer | Q37690299 | ||
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele | Q37705080 | ||
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor | Q38432619 | ||
Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma | Q38466547 | ||
Missense mutation of the MET gene detected in human glioma | Q38525862 | ||
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. | Q39702478 | ||
E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models | Q39787136 | ||
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. | Q39813764 | ||
Small molecule c-MET inhibitor PHA665752: effect on cell growth and motility in papillary thyroid carcinoma | Q40004623 | ||
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts | Q40050768 | ||
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum | Q40240700 | ||
MET overexpression turns human primary osteoblasts into osteosarcomas. | Q40285015 | ||
Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma | Q40333091 | ||
Somatic mutations lead to an oncogenic deletion of met in lung cancer | Q40333112 | ||
Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation | Q40408804 | ||
HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion | Q40490783 | ||
Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels | Q40546756 | ||
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. | Q40761395 | ||
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth | Q40765252 | ||
c-met proto-oncogene expression in benign and malignant human prostate tissues | Q40981774 | ||
Amplified met gene linked to double minutes in human glioblastoma | Q41584617 | ||
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. | Q42454085 | ||
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility | Q42807925 | ||
Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo | Q42809563 | ||
Novel mutations of the MET proto-oncogene in papillary renal carcinomas. | Q42815807 | ||
Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemia | Q43212290 | ||
c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. | Q44810921 | ||
Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells | Q44986030 | ||
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas | Q45345804 | ||
Molecular cloning of a new transforming gene from a chemically transformed human cell line. | Q45345810 | ||
Prognostic significance of c-Met expression in glioblastomas | Q46170165 | ||
Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherin | Q46176116 | ||
MET receptor tyrosine kinase sequence alterations in differentiated thyroid carcinoma | Q46379055 | ||
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice. | Q51828709 | ||
c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma. | Q52122642 | ||
Clinical correlations and prognostic relevance of HGF, VEGF AND FGF expression in Brazilian patients with non-Hodgkin lymphoma. | Q53221535 | ||
Frequent amplification of the c-met gene in scirrhous type stomach cancer. | Q53486015 | ||
Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. | Q53875696 | ||
Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. | Q54158447 | ||
Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. | Q54584505 | ||
Correlation of clinicopathological parameters with HGF, c-Met, EGFR, and IGF-1R expression in uveal melanoma. | Q54699355 | ||
Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma. | Q55043279 | ||
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. | Q55284672 | ||
Amplification of the MET gene in glioma. | Q55481480 | ||
Effect of c-Met Expression on Survival in Head and Neck Squamous Cell Carcinoma | Q57765077 | ||
Comparison of hepatocyte growth factor levels of epithelial ovarian cancer cyst fluids with benign ovarian cysts | Q75421957 | ||
P433 | issue | 9 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1225-1241 | |
P577 | publication date | 2011-07-11 | |
P1433 | published in | Expert Opinion on Investigational Drugs | Q5421208 |
P1476 | title | Development of c-MET pathway inhibitors | |
P478 | volume | 20 |
Q39016480 | A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers |
Q33635671 | Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway |
Q35159738 | Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors |
Q39781895 | Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors |
Q38770450 | Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups. |
Q33551889 | Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations |
Q36762751 | Hepatic Radiofrequency Ablation-induced Stimulation of Distant Tumor Growth Is Suppressed by c-Met Inhibition |
Q37017085 | Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer |
Q92400515 | Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis |
Q39236947 | Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors |
Q37018397 | Ligand-independent activation of MET through IGF-1/IGF-1R signaling |
Q54196176 | LncRNA expression profiles of EGFR exon 19 deletions in lung adenocarcinoma ascertained by using microarray analysis. |
Q64069891 | Matrix Metalloproteinase 11 Is a Potential Therapeutic Target in Lung Adenocarcinoma |
Q38390049 | Molecular determinants of lung cancer metastasis to the central nervous system |
Q37984612 | Novel targets for VEGF-independent anti-angiogenic drugs. |
Q35036012 | Proliferation of colorectal cancer is promoted by two signaling transduction expression patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK |
Q35051588 | Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors |
Q38056554 | Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist. |
Q26764899 | Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications |
Q39127629 | Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors. |
Q28513426 | Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation |
Q35740444 | The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy |
Q34365135 | The current status of tailor-made medicine with molecular biomarkers for patients with clear cell renal cell carcinoma |