Development of c-MET pathway inhibitors

scientific article

Development of c-MET pathway inhibitors is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1517/13543784.2011.600687
P698PubMed publication ID21740293

P2093author name stringXiangdong Liu
Peggy A Scherle
Robert C Newton
P2860cites workMolecular cloning and expression of human hepatocyte growth factorQ24305558
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesisQ24683896
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamilyQ27654013
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivoQ27658318
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancerQ27851588
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisQ28139783
Met, metastasis, motility and moreQ28235183
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factorQ28307227
Scatter factor/hepatocyte growth factor is essential for liver developmentQ28504542
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesQ28513246
Epidermal growth factor receptor mutations in lung cancerQ29615474
Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cellsQ33922202
c-Met as a target for human cancer and characterization of inhibitors for therapeutic interventionQ34422211
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.Q34454578
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Drug development of MET inhibitors: targeting oncogene addiction and expedienceQ34782774
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastasesQ35199181
Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulationQ35277738
Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cellsQ36090650
Signaling networks assembled by oncogenic EGFR and c-MetQ36392991
RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumorsQ36540061
The mutationally activated Met receptor mediates motility and metastasisQ36735738
Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemiaQ36988579
Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancerQ37111358
Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cellsQ37141943
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancerQ37293236
Novel therapeutic inhibitors of the c-Met signaling pathway in cancerQ37422804
Molecularly targeted therapies for thyroid cancers.Q37527371
Clinical implications of MET gene copy number in lung cancerQ37690299
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant alleleQ37705080
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptorQ38432619
Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinomaQ38466547
Missense mutation of the MET gene detected in human gliomaQ38525862
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.Q39702478
E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft modelsQ39787136
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.Q39813764
Small molecule c-MET inhibitor PHA665752: effect on cell growth and motility in papillary thyroid carcinomaQ40004623
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenograftsQ40050768
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinumQ40240700
MET overexpression turns human primary osteoblasts into osteosarcomas.Q40285015
Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesotheliomaQ40333091
Somatic mutations lead to an oncogenic deletion of met in lung cancerQ40333112
Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiationQ40408804
HGF converts ErbB2/Neu epithelial morphogenesis to cell invasionQ40490783
Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levelsQ40546756
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.Q40761395
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growthQ40765252
c-met proto-oncogene expression in benign and malignant human prostate tissuesQ40981774
Amplified met gene linked to double minutes in human glioblastomaQ41584617
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.Q42454085
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivoQ42809563
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemiaQ43212290
c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.Q44810921
Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cellsQ44986030
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Prognostic significance of c-Met expression in glioblastomasQ46170165
Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherinQ46176116
MET receptor tyrosine kinase sequence alterations in differentiated thyroid carcinomaQ46379055
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice.Q51828709
c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma.Q52122642
Clinical correlations and prognostic relevance of HGF, VEGF AND FGF expression in Brazilian patients with non-Hodgkin lymphoma.Q53221535
Frequent amplification of the c-met gene in scirrhous type stomach cancer.Q53486015
Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients.Q53875696
Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors.Q54158447
Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome.Q54584505
Correlation of clinicopathological parameters with HGF, c-Met, EGFR, and IGF-1R expression in uveal melanoma.Q54699355
Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma.Q55043279
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance.Q55284672
Amplification of the MET gene in glioma.Q55481480
Effect of c-Met Expression on Survival in Head and Neck Squamous Cell CarcinomaQ57765077
Comparison of hepatocyte growth factor levels of epithelial ovarian cancer cyst fluids with benign ovarian cystsQ75421957
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1225-1241
P577publication date2011-07-11
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleDevelopment of c-MET pathway inhibitors
P478volume20

Reverse relations

cites work (P2860)
Q39016480A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers
Q33635671Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway
Q35159738Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors
Q39781895Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors
Q38770450Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups.
Q33551889Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations
Q36762751Hepatic Radiofrequency Ablation-induced Stimulation of Distant Tumor Growth Is Suppressed by c-Met Inhibition
Q37017085Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer
Q92400515Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis
Q39236947Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors
Q37018397Ligand-independent activation of MET through IGF-1/IGF-1R signaling
Q54196176LncRNA expression profiles of EGFR exon 19 deletions in lung adenocarcinoma ascertained by using microarray analysis.
Q64069891Matrix Metalloproteinase 11 Is a Potential Therapeutic Target in Lung Adenocarcinoma
Q38390049Molecular determinants of lung cancer metastasis to the central nervous system
Q37984612Novel targets for VEGF-independent anti-angiogenic drugs.
Q35036012Proliferation of colorectal cancer is promoted by two signaling transduction expression patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK
Q35051588Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors
Q38056554Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist.
Q26764899Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications
Q39127629Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors.
Q28513426Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation
Q35740444The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy
Q34365135The current status of tailor-made medicine with molecular biomarkers for patients with clear cell renal cell carcinoma