Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist.

scientific article published on 30 October 2012

Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/ANNONC/MDS520
P698PubMed publication ID23110808
P5875ResearchGate publication ID232740629

P50authorLuca GianniQ56629673
Massimo BrogginiQ58377329
P2093author name stringC Sessa
A Fasolo
P2860cites workAntiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisQ24608039
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197Q24608143
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancerQ27851588
Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrenceQ27851725
A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivoQ28270305
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survivalQ28282398
Development of c-MET pathway inhibitorsQ34198905
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
Drug development of MET inhibitors: targeting oncogene addiction and expedienceQ34782774
Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.Q35203637
The MET receptor tyrosine kinase in invasion and metastasisQ36868644
Targeting the MET oncogene in cancer and metastases.Q37792116
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer.Q38409218
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growthQ39472261
Ron kinase transphosphorylation sustains MET oncogene addictionQ39611289
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.Q39702478
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenograftsQ40050768
MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterationsQ42731321
A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2.Q43062314
A phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumorsQ43091672
Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factorQ46121750
Targeting the HGF/c-Met axis: state of play.Q54676546
P433issue1
P921main subjectpharmacologyQ128406
P304page(s)14-20
P577publication date2012-10-30
P1433published inAnnals of OncologyQ326122
P1476titleSeminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist
P478volume24

Reverse relations

cites work (P2860)
Q27302940Combination of the c-Met inhibitor tivantinib and zoledronic acid prevents tumor bone engraftment and inhibits progression of established bone metastases in a breast xenograft model
Q90119555Development of c‑MET‑specific chimeric antigen receptor‑engineered natural killer cells with cytotoxic effects on human liver cancer HepG2 cells
Q38940200Essential role of Her3 in two signaling transduction patterns: Her2/Her3 and MET/Her3 in proliferation of human gastric cancer
Q36574080Evaluation of safety and efficacy of tivantinib in the treatment of inoperable or recurrent non-small-cell lung cancer
Q38199128Recent advances and future trends in the targeted therapy of metastatic gastric cancer
Q48140297Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma
Q89967621The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
Q38956071Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines

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