Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors.

scientific article published on 10 July 2013

Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ARDP.201300087
P698PubMed publication ID23843304

P50authorDi WuQ64532738
P2093author name stringPing Gong
Baohui Qi
Haiyan Tao
Jinying Bai
Yandan Shi
P2860cites workPreclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihyQ39616531
Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.Q39751438
Toward safer processes for C-C biaryl bond construction: catalytic direct C-H arylation and tin-free radical coupling in the synthesis of pyrazolophenanthridinesQ43226335
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitorsQ43255650
Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domainsQ44103436
N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptorQ44388155
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compoundsQ44476042
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinaseQ27650405
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activitiesQ27651475
Design, synthesis, and biological evaluation of potent c-Met inhibitorsQ27651910
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinasesQ27657708
Met, metastasis, motility and moreQ28235183
Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3Q28256422
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidatesQ34088416
Small molecule c-Met kinase inhibitors: a review of recent patentsQ34094632
Development of c-MET pathway inhibitorsQ34198905
c-Met as a target for human cancer and characterization of inhibitors for therapeutic interventionQ34422211
Structural basis of hepatocyte growth factor/scatter factor and MET signallingQ34572895
Progress in cancer therapy targeting c-Met signaling pathwayQ38007133
Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitorsQ39457824
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffoldQ39526161
Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networksQ39528185
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)596-609
P577publication date2013-07-10
P1433published inArchiv der Pharmazie - Chemistry in Life SciencesQ10533542
P1476titleSynthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors
P478volume346

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cites work (P2860)
Q35603900A rapid and sensitive LC-MS/MS method for evaluation of the absolute oral bioavailability of a novel c-Met tyrosine kinase inhibitor QBH-196 in rats
Q38718891Design and Synthesis of Novel 4-Phenoxyquinolines Bearing 3-Hydrosulfonylacrylamido or 1H-Imidazole-4-carboxamido Scaffolds as c-Met Kinase Inhibitors
Q38765409Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors

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