Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors

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Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C4OB00364K
P698PubMed publication ID24781551

P2093author name stringSheng Liu
Fajun Nan
Jing Ai
Xia Peng
Meiyu Geng
Jimin Xu
Linqian Yu
P2860cites workIdentification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survivalQ28282398
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumorsQ28295039
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretionQ29617359
Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesisQ31053049
Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasisQ33786959
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidatesQ34088416
Small molecule c-Met kinase inhibitors: a review of recent patentsQ34094632
Development of c-MET pathway inhibitorsQ34198905
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Drug development of MET inhibitors: targeting oncogene addiction and expedienceQ34782774
Mechanisms and significance of bifunctional NK4 in cancer treatment.Q36160343
Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivoQ37133949
Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.Q37223558
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
Targeting the heat shock protein 90 dimer with dimeric inhibitorsQ38604353
Enantioselective total syntheses of trichodermamides A and B.Q39922084
Expeditious synthesis of benzopyrans via Lewis acid-catalyzed C-H functionalization: remarkable enhancement of reactivity by an ortho substituentQ43123804
Biscoumarin: new class of urease inhibitors; economical synthesis and activity.Q44401752
C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neuQ45083973
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.Q51759767
Effect of c-Met Expression on Survival in Head and Neck Squamous Cell CarcinomaQ57765077
P433issue22
P304page(s)3721-3734
P577publication date2014-04-30
P1433published inOrganic and Biomolecular ChemistryQ3355939
P1476titleDesign and synthesis of 3,3'-biscoumarin-based c-Met inhibitors
P478volume12

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Q50245721Total syntheses of gerberinol I and the pterophyllins 2 and 4 using the Casnati-Skattebøl reaction under different conditionscites workP2860

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