Determination of a novel anticancer c-Met inhibitor LS-177 in rat plasma and tissues with a validated UPLC-MS/MS method: application to pharmacokinetics and tissue distribution study

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Determination of a novel anticancer c-Met inhibitor LS-177 in rat plasma and tissues with a validated UPLC-MS/MS method: application to pharmacokinetics and tissue distribution study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/BMC.3397
P698PubMed publication ID25472760

P2093author name stringXiaohui Chen
Xing Tang
Yuanyuan Zhang
Yu Jiang
Kaishun Bi
Liqiang Gu
Zhenzhen Liu
Ping Ju
Simin Zhao
Lunhui Zhang
P2860cites workAn adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl bindingQ24316997
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitorsQ27650612
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinasesQ27657708
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaQ30494514
Nanoparticulate systems for brain delivery of drugsQ33938252
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidatesQ34088416
Small molecule c-Met kinase inhibitors: a review of recent patentsQ34094632
c-Met as a target for human cancer and characterization of inhibitors for therapeutic interventionQ34422211
Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.Q35203637
MET receptor tyrosine kinase as a therapeutic anticancer targetQ37356047
Design, synthesis, and structure-activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agentsQ39099004
Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitorsQ39158608
Down-regulation of c-Met expression inhibits human HCC cells growth and invasion by RNA interferenceQ39797652
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitorsQ43255650
Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluationQ44192096
A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors.Q54478410
A comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors.Q54649963
P433issue7
P921main subjectpharmacokineticsQ323936
P304page(s)1103-1111
P577publication date2014-12-04
P1433published inBiomedical ChromatographyQ4915104
P1476titleDetermination of a novel anticancer c-Met inhibitor LS-177 in rat plasma and tissues with a validated UPLC-MS/MS method: application to pharmacokinetics and tissue distribution study
P478volume29

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cites work (P2860)
Q37520428Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy
Q38845681miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-Met

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