Activated HGF-c-Met Axis in Head and Neck Cancer

scientific article published on 12 December 2017

Activated HGF-c-Met Axis in Head and Neck Cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CANCERS9120169
P932PMC publication ID5742817
P698PubMed publication ID29231907

P2093author name stringSufi Mary Thomas
Levi Arnold
Jonathan Enders
P2860cites workThe Hallmarks of CancerQ221226
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphataseQ24316395
Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitorQ24321843
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitorQ24322087
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityQ24336040
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptorsQ24339620
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in miceQ24561588
ret transforming gene encodes a fusion protein homologous to tyrosine kinasesQ24628687
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3Q24633878
An overview of the c-MET signaling pathwayQ24633986
Wnt signal transduction pathwaysQ24641814
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c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regenerationQ27300880
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)Q27671432
Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survivalQ27851502
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor proteinQ28114826
Met receptor tyrosine kinase: enhanced signaling through adapter proteinsQ28140219
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLQ28141139
Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa BQ28216726
Met, metastasis, motility and moreQ28235183
Induction of epithelial tubules by growth factor HGF depends on the STAT pathwayQ28259695
Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cellsQ28270220
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinaseQ28280668
Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoproteinQ28281666
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Scatter factor/hepatocyte growth factor is essential for liver developmentQ28504542
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase-type plasminogen activator receptorQ48017929
Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneuronsQ48046833
Overexpression of the Met/HGF receptor in ovarian cancer.Q48079353
Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomasQ48146638
Characterization of the mouse met proto-oncogene.Q48322818
Changes in gene expression during progression of ovarian carcinomaQ49222374
Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis.Q53394866
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.Q53479014
Evidence for non-covalent clusters of the c-met proto-oncogene productQ54269961
Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c-Met signaling.Q54295790
Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas.Q54315132
Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.Q54351298
Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells.Q54391771
Hepatocyte growth factor receptor, c-Met, in human embryo salivary glands. An immunohistochemical study.Q54685062
MET Y1253D-activating point mutation and development of distant metastasis in advanced head and neck cancers.Q54729777
Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric ReactionQ57281116
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene AddictionQ58164795
Abstract 1889: Smad4 inactivation correlates with EMT and cetuximab resistance in head and neck squamous cell carcinomaQ59089010
A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulationQ59971496
Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized ratsQ60034429
Structure and biological property of fibroblast-derived tumor cytotoxic factor (F-TCF)Q67929913
The human met oncogene is a member of the tyrosine kinase familyQ68241918
A study of an in vitro model for invasion of oral squamous cell carcinomaQ69418700
Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomasQ71061803
Expression of Met protein in thyroid tumoursQ71870884
Expression and localization of hepatocyte growth factor in rat submandibular glandQ72146134
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuitQ72560868
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancerQ72571222
Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factorQ73067636
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomasQ73586595
Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastasesQ73911408
u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinomaQ74108509
Overexpression of scatter factor and its receptor (c-met) in oral squamous cell carcinomaQ77303734
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancerQ77555522
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomasQ77931840
Purification and characterization of hepatocyte growth factor from injured liver of carbon tetrachloride-treated ratsQ28567221
Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphataseQ28577402
The mutational landscape of head and neck squamous cell carcinomaQ29614654
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapiesQ29615606
Wnt activity defines colon cancer stem cells and is regulated by the microenvironmentQ29618024
Functions of cell surface heparan sulfate proteoglycansQ29618521
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaQ29618875
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaQ30494514
Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant proteinQ33324580
Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factorQ33324581
Platinum-based chemotherapy plus cetuximab in head and neck cancerQ33381094
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survivalQ33515519
Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-MetQ33702320
Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissuesQ33842687
Hepatocyte growth factor promotes lymphatic vessel formation and functionQ33919993
Chemically oversulfated glycosaminoglycans are potent modulators of contact system activation and different cell signaling pathwaysQ34003880
Clinicopathological predictors of lymphatic metastasis in HNSCC: implications for molecular mechanisms of metastatic diseaseQ34091198
Characterization of the rearranged tpr-met oncogene breakpointQ34191799
Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neckQ34287207
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinaseQ34358610
Proteoglycans: pericellular and cell surface multireceptors that integrate external stimuli in the mammary glandQ34362776
Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinaseQ34384347
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locusQ34407347
Detection of MET oncogene/hepatocyte growth factor receptor in lymph node metastases from head and neck squamous cell carcinomas.Q34419289
Common critical pathways in embryogenesis and cancerQ34535747
Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic degradative pathway.Q34632213
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximabQ35001415
Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Q35056355
Novel role for endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms.Q35079472
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cellsQ35110418
HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancerQ35174872
Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.Q35782214
Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinomaQ35796063
CD44 is required for two consecutive steps in HGF/c-Met signaling.Q35805198
Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancerQ35829554
Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas.Q38777541
Mitigation of Tumor-Associated Fibroblast-Facilitated Head and Neck Cancer Progression With Anti-Hepatocyte Growth Factor Antibody Ficlatuzumab.Q38821826
Crizotinib Fails to Enhance the Effect of Radiation in Head and Neck Squamous Cell Carcinoma XenograftsQ38824660
Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cellsQ38862494
Cancer Statistics, 2017.Q39038674
A fibroblast-derived tumor cytotoxic factor/F-TCF(hepatocyte growth factor/HGF) has multiple functions in vitroQ39101294
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factorQ39101924
Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitorsQ39158608
A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.Q39473718
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growthQ39750624
E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft modelsQ39787136
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
Mature hepatocyte growth factor/scatter factor on the surface of human granulocytes is released by a mechanism involving activated factor Xa.Q40278091
The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivoQ40377167
Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failureQ40510836
Oligomerization-induced Modulation of TPR-MET Tyrosine Kinase ActivityQ40652658
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesisQ40755904
Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cellsQ40935169
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivoQ41052630
Transient and locally restricted expression of the ros1 protooncogene during mouse developmentQ41083296
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-METQ41152225
Overexpression of the met/HGF receptor in renal cell carcinomasQ41190769
The receptor encoded by the human C-MET oncogene is expressed in testicular tissue and on human spermatozoaQ41241902
Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cellsQ41375138
Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger.Q41554332
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growthQ41596252
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factorQ41656206
Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell linesQ41660621
Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishableQ41666984
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinaseQ41690281
Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formationQ41711750
HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletionQ41834933
Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factorQ42435592
Silencing Met receptor tyrosine kinase signaling decreased oral tumor growth and increased survival of nude mice.Q42735478
Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesisQ42796653
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).Q42802867
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
Mechanism of met oncogene activationQ42811433
Tyrosine kinase receptor indistinguishable from the c-met proteinQ42814654
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and NeckQ43164702
Down-regulation of MET, the receptor for hepatocyte growth factor.Q43649368
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neuronsQ43819365
An epithelial scatter factor released by embryo fibroblasts.Q43820611
MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.Q43827034
Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinomaQ43865519
Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophilsQ43945200
Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomasQ44363232
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignanciesQ45246419
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Do morphogen gradients arise by diffusion?Q46502677
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cellsQ46722158
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domainQ47072621
Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis.Q47975607
Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancerQ36005545
Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogeneQ36065558
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cellsQ36223889
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary glandQ36236069
Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.Q36236835
Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancerQ36286731
Expression of c-Met Is Different along the Location and Associated with Lymph Node Metastasis of Head and Neck CarcinomaQ36518737
c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-MetQ36545205
Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis networkQ36557528
Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.Q36660533
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylationQ36687206
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.Q36689648
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factorQ36705281
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of MetQ36777999
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.Q36860354
Targeting HER proteins in cancer therapy and the role of the non-target HER3.Q36898642
Heparanase 2 Attenuates Head and Neck Tumor Vascularity and GrowthQ36917969
Ten years of progress in head and neck cancersQ37002445
Hepatocyte growth factor--scatter factor: mitogen, motogen, and metQ37105518
Cancer as an overhealing wound: an old hypothesis revisitedQ37217254
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesisQ37329953
Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary culturesQ37397472
Alteration status and prognostic value of MET in head and neck squamous cell carcinomaQ37514050
Evidence for the identity of human scatter factor and human hepatocyte growth factorQ37574028
MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapyQ37597858
Mechanisms of hepatocyte growth factor activation in cancer tissuesQ38255480
Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynxQ38450015
Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinomaQ38466547
Cellular and molecular mechanisms of HGF/Met in the cardiovascular system.Q38631649
Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectinQ38730122
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and TreatmentQ38761147
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P577publication date2017-12-12
P1433published inCancersQ27722963
P1476titleActivated HGF-c-Met Axis in Head and Neck Cancer
P478volume9

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cites work (P2860)
Q91902169Clinical update on head and neck cancer: molecular biology and ongoing challenges
Q89823731Crosstalk Mechanisms Between HGF/c-Met Axis and ncRNAs in Malignancy
Q60920855HGF/c-MET Signaling in Melanocytes and Melanoma
Q58574781HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers
Q92531037Hepatocyte Growth Factor Receptor overexpression predicts reduced survival but its targeting is not effective in unselected HNSCC patients
Q64238086Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma
Q97074416Structural and Functional Insight Into the Glycosylation Impact Upon the HGF/c-Met Signaling Pathway
Q90620359Targeting cancer stem cells in squamous cell carcinoma
Q92661565The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma
Q61818143c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells

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