Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma.

scientific article published on 29 January 2016

Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00428-016-1905-1
P698PubMed publication ID26832731

P50authorEde BirtalanQ56811247
Bianka GurbiQ87203128
P2093author name stringTibor Krenács
István Peták
Diána Brauswetter
Nóra Meggyesházi
László Tamás
Kornél Dános
Éva Fruzsina Félegyházi
P2860cites workC-Met pathway promotes self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cellQ38212355
Human papillomavirus and Epstein Barr virus in head and neck carcinomas: suggestions for the new WHO classificationQ38255620
Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplificationQ38370754
Correlations between prognosis and regional biomarker profiles in head and neck squamous cell carcinomasQ38388575
Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancerQ39503071
Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirusQ42674338
Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomasQ46127298
Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA statusQ49215383
Differential biomarker expression in head and neck cancer correlates with anatomical localization.Q51871346
PIK3CA Pathway Mutations Predictive of Poor Response Following Standard Radiochemotherapy ± Cetuximab in Cervical Cancer Patients.Q54287725
Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.Q54341358
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS studyQ57152185
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patientsQ58813317
Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinomaQ58827057
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME studyQ27851592
EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX studyQ27851683
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkersQ27852227
Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangementQ27852650
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Q27861047
Met, metastasis, motility and moreQ28235183
Comprehensive genomic characterization of head and neck squamous cell carcinomasQ28256121
COSMIC: exploring the world's knowledge of somatic mutations in human cancerQ29615725
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaQ30494514
Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinomaQ31096247
Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistanceQ34161089
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
Targeting MET Amplification as a New Oncogenic Driver.Q34309927
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.Q34536780
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancerQ34557318
PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.Q35068192
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patientsQ35926926
Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinomaQ35994228
EGFR status in oral squamous cell carcinoma: comparing immunohistochemistry, FISH and CISH detection in a case series studyQ36584164
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patientsQ36755257
Cetuximab: its unique place in head and neck cancer treatmentQ36880604
The biological role of HGF-MET axis in tumor growth and development of metastasisQ36992086
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients.Q37321772
MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinomaQ37490555
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
The molecular biology of head and neck cancerQ37821229
Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinomaQ37990112
P433issue5
P304page(s)579-587
P577publication date2016-01-29
P1433published inVirchows ArchivQ19059548
P1476titleCopy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma
P478volume468

Reverse relations

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