Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation

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Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.084335
P932PMC publication ID2836056
P698PubMed publication ID20018857

P2093author name stringLeena P Desai
Steven R White
Christopher M Waters
P2860cites workRegulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activationQ24678943
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Integrin activation and matrix binding mediate cellular responses to mechanical stretchQ30436223
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Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.Q36977342
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Role of ErbB2 in Corneal Epithelial Wound HealingQ37152335
Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cellsQ37337513
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinaseQ38330900
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Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via PI3K activationQ40011710
Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cellsQ40106257
Dominant-negative Rac increases both inherent and ionizing radiation-induced cell migration in C6 rat glioma cellsQ40351675
Laminin 5 expression protects against anoikis at aerogenous spread and lepidic growth of human lung adenocarcinoma.Q40430155
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptorQ40491784
Alpha-melanocyte stimulating hormone protects against H2O2-induced inhibition of wound restitution in IEC-6 cells via a Syk kinase- and NF-kappabeta-dependent mechanismQ40503192
RhoA and Rac1 are both required for efficient wound closure of airway epithelial cellsQ40527674
The basement membrane protein laminin-5 acts as a soluble cell motility factorQ40542384
Culture and transformation of human airway epithelial cellsQ40618101
Calcium regulates the PI3K-Akt pathway in stretched osteoblastsQ40670822
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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.Q41075804
Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.Q41270218
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The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.Q42189937
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Epidermal growth factor receptor-dependent PI3K-activation promotes restitution of wounded human gastric epithelial monolayersQ42517723
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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinaseQ42807993
Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domainQ42834604
Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cellsQ44342317
Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cellsQ44456822
Mechanosensitive p27Kip1 regulation and cell cycle entry in vascular smooth muscle cellsQ44497564
Ras-induced spreading and wound closure in human epidermal keratinocytesQ46709543
Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cellsQ46843762
Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cellsQ46966252
Mathematical modeling of airway epithelial wound closure during cyclic mechanical strainQ48033304
Airway structural alterations selectively associated with severe asthma.Q51690348
HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation.Q54650079
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Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitroQ64381136
Migration of bovine bronchial epithelial cells to extracellular matrix componentsQ70523645
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Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroidQ73730842
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasionQ74037504
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Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strainQ77341921
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migrationQ77353628
Collagen deposition in large airways may not differentiate severe asthma from milder forms of the diseaseQ77660831
Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signalingQ80609623
Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathwaysQ81668348
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)4511-4519
P577publication date2009-12-14
P1433published inJournal of Biological ChemistryQ867727
P1476titleCyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation
P478volume285

Reverse relations

cites work (P2860)
Q33708583A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing.
Q34717955Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis
Q35325284Balance of life and death in alveolar epithelial type II cells: proliferation, apoptosis, and the effects of cyclic stretch on wound healing
Q90230200Cancer invasion into musculature: Mechanics, molecules and implications
Q33916933Epithelial repair mechanisms in the lung
Q30799346Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching.
Q34364747Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun
Q41752423Hybrid mechanosensing system to generate the polarity needed for migration in fish keratocytes
Q61811617Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip
Q36309746Kymographic Imaging of the Elastic Modulus of Epithelial Cells during the Onset of Migration
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Q36621928Myosin-II-mediated directional migration of Dictyostelium cells in response to cyclic stretching of substratum
Q34228582PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration
Q35543310Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells
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Q58566840The Role of PI3K in Met Driven Cancer: A Recap
Q60302238Type VI collagen promotes lung epithelial cell spreading and wound-closure

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