Neurotoxic mechanisms of degeneration in motor neuron diseases

scientific article

Neurotoxic mechanisms of degeneration in motor neuron diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1081/DMR-100101938
P698PubMed publication ID10461543

P2093author name stringLudolph AC
Münch C
P2860cites workAggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1Q22299419
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloproteaseQ24309083
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An excitatory amino-acid transporter with properties of a ligand-gated chloride channelQ24323343
Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brainQ24563212
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisQ28131805
Cloning and expression of a rat brain L-glutamate transporterQ28203723
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosisQ28267385
Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosisQ28270636
RNA editing in brain controls a determinant of ion flow in glutamate-gated channelsQ28279138
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutaseQ28284593
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injuryQ28511628
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndromeQ28592168
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1Q28592689
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationQ29547561
Superoxide radical and superoxide dismutasesQ29614204
Cloned glutamate receptorsQ29619950
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamateQ29620128
Tissue specific variants of glutamate transporter GLT-1.Q30090179
Comparison of sporadic and familial disease amongst 580 cases of motor neuron diseaseQ33631319
Primary structure and functional characterization of a high-affinity glutamate transporterQ34205379
Brain lesions in an infant rhesus monkey treated with monsodium glutamateQ34240164
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosisQ34300016
Glutamate neurotoxicity and diseases of the nervous systemQ34560997
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neuronsQ34667159
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosisQ34736976
Alternative excitotoxic hypothesesQ35227246
Are human neurodegenerative disorders linked to environmental chemicals with excitotoxic properties?Q35230778
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?Q35254212
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activityQ35693516
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicityQ36420529
A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxideQ37550536
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesionsQ37688651
Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampusQ38300706
Genomic organization of the human excitatory amino acid transporter gene GLT-1.Q38348472
Excitotoxicity, energy metabolism and neurodegenerationQ40713305
Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of functionQ41111012
Toxic models of upper motor neuron diseaseQ41194822
Mitochondria, free radicals, and neurodegenerationQ41235574
Ischemia-induced neuronal apoptosisQ41235586
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).Q41351491
The EAAT2 (GLT-1) gene in motor neuron disease: absence of mutations in amyotrophic lateral sclerosis and a point mutation in patients with hereditary spastic paraplegiaQ41843474
Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.Q42201775
Splicing of the glutamate transporter EAAT2: a candidate gene of amyotrophic lateral sclerosisQ42912839
Excitotoxic disordersQ44405122
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosisQ45291121
The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosisQ45882912
Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesisQ46162628
Deficient glutamate transport is associated with neurodegeneration in Alzheimer's diseaseQ46372282
5'-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1).Q47959438
Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic miceQ47996542
Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor geneQ48045866
Parvalbumin and calbindin D-28k in the human motor system and in motor neuron diseaseQ48241885
Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.Q48242571
Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patientsQ48466261
Alternative splicing of the glutamate transporter EAAT2 (GLT-1).Q48510470
Studies of the coding region of the neuronal glutamate transporter gene in amyotrophic lateral sclerosis.Q53011672
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondriaQ54965159
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNSQ57378339
Immunohistochemical mapping of calcium-binding protein immunoreactivity in the rat central nervous systemQ70337731
Oxidative stress in neurodegenerative diseasesQ71306903
Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosisQ71483679
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectneurotoxicityQ3338704
P304page(s)619-634
P577publication date1999-08-01
P1433published inDrug Metabolism ReviewsQ5308857
P1476titleNeurotoxic mechanisms of degeneration in motor neuron diseases
P478volume31

Reverse relations

cites work (P2860)
Q49047132Calcineurin A and calbindin immunoreactivity in the spinal cord of G93A superoxide dismutase transgenic mice
Q39747906Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage
Q28190140Glutamate uptake
Q44807720Physiopathology of ALS: therapeutic approach
Q24681228Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis