The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells

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The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...513445M
P356DOI10.1371/JOURNAL.PONE.0013445
P932PMC publication ID2956662
P698PubMed publication ID20976148
P5875ResearchGate publication ID47545532

P50authorMarvin J FritzlerQ63302292
Joanna J MoserQ38319954
P2860cites workGenome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell linesQ21143768
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54Q21146051
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencingQ24310166
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic specklesQ24515264
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencingQ24537488
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodiesQ24540223
A microRNA expression signature of human solid tumors defines cancer gene targetsQ24541455
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesQ24554481
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cellsQ24603505
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
miR-34a repression of SIRT1 regulates apoptosisQ24652720
Most mammalian mRNAs are conserved targets of microRNAsQ24655061
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoreQ24682934
The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencingQ27654194
Argonaute2 is the catalytic engine of mammalian RNAiQ27860545
Unique microRNA molecular profiles in lung cancer diagnosis and prognosisQ27860631
MicroRNA gene expression deregulation in human breast cancerQ27860690
A comparison of normalization methods for high density oligonucleotide array data based on variance and biasQ27860710
A microRNA polycistron as a potential human oncogeneQ27860720
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Q27860893
MicroRNA signatures in human cancersQ27860962
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing BodiesQ27931286
MicroRNA expression profiles classify human cancersQ28032481
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexesQ28115751
Switching from repression to activation: microRNAs can up-regulate translationQ28131790
Tumour invasion and metastasis initiated by microRNA-10b in breast cancerQ28131829
MicroRNA signatures in human ovarian cancerQ28249211
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cellsQ28249223
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cellsQ28262214
Extensive modulation of a set of microRNAs in primary glioblastomaQ28263314
P bodies: at the crossroads of post-transcriptional pathwaysQ28280058
Mechanisms of gene silencing by double-stranded RNAQ28282560
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cellsQ28287986
A microRNA component of the p53 tumour suppressor networkQ28305330
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Astrocytes are active players in cerebral innate immunityQ29620562
microRNA-34a is tumor suppressive in brain tumors and glioma stem cellsQ30428366
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenesQ30434616
MicroRNAs in cancerQ30437444
Cytoplasmic ribonucleoprotein (RNP) bodies and their relationship to GW/P bodiesQ30925040
microRNAs join the p53 network--another piece in the tumour-suppression puzzleQ33344707
Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growthQ33348593
Correlation of expression profiles between microRNAs and mRNA targets using NCI-60 dataQ33444270
Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulationQ33529047
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.Q53306726
Association of microRNA-34a overexpression with proliferation is cell type-dependent.Q53328782
17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulationQ82081731
Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P bodiesQ33552925
The molecular basis of water transport in the brainQ34284711
The role of GW/P-bodies in RNA processing and silencingQ34578258
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.Q34986356
miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53.Q34991097
Formation of GW bodies is a consequence of microRNA genesisQ35016215
Autoimmune targeting of key components of RNA interferenceQ35605638
In situ synthesis of oligonucleotide microarraysQ35719447
Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibodyQ35878451
Revealing the world of RNA interferenceQ35889563
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodiesQ35949029
The MYCN oncogene is a direct target of miR-34aQ36926506
The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brainQ37395741
Emerging functions of microRNAs in glioblastomaQ37439491
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencingQ37522850
Advances in RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray profilingQ38292316
microParaflo biochip for nucleic acid and protein analysisQ38294233
MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC.Q38353056
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.Q39810065
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicityQ39893180
Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencingQ39908800
miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cellsQ39917469
Cell-cycle control of microRNA-mediated translation regulationQ39983744
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrestQ39992760
Regulation of p27Kip1 by miRNA 221/222 in glioblastomaQ40089204
Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodiesQ40100651
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.Q40154871
A C-terminal silencing domain in GW182 is essential for miRNA functionQ41908974
P-body formation is a consequence, not the cause, of RNA-mediated gene silencingQ42738042
Neuroscience. Glia tell neurons to build synapsesQ43535309
MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells.Q44738304
The spanish connection: transcription and mRNA processing get even closerQ46330518
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decayQ46698175
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectastrocytomaQ177755
microRNAQ310899
astrocyteQ502961
P304page(s)e13445
P577publication date2010-10-18
P1433published inPLOS OneQ564954
P1476titleThe microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells
P478volume5

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