Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes

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Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1084/JEM.190.5.591
P932PMC publication ID2195610
P698PubMed publication ID10477544
P5875ResearchGate publication ID12821669

P2093author name stringJ J Oppenheim
J M Wang
P2860cites workHIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulationQ22003981
Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cellsQ22009940
Lymphocyte activation by HIV-1 envelope glycoproteinQ28281341
A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infectionQ28379184
A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptorQ28379187
Chemoattractant receptor cross-desensitizationQ33536432
Chemokine receptors and HIV-1: the fusion of two major research fieldsQ33546863
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domainsQ36186612
The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strainsQ36375284
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.Q36380882
Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.Q36401415
Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infectionQ36602638
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activityQ36765049
Pharmacology of pertussis toxin B-oligomerQ38358142
HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.Q38869431
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptorQ38878235
Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategyQ38941762
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionQ38949380
HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.Q39000361
Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulationQ39036696
T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: implications for HIV pathogenesisQ39097279
Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5.Q39160311
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.Q39464587
Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells.Q39581009
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptorQ39585768
Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal applicationQ41033142
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell linesQ41157521
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposureQ41212897
Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.Q41229926
HIV entry and tropism: the chemokine receptor connection.Q41694886
Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokinesQ46722581
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.Q47914580
Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptorQ49200390
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.Q55067967
A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cellsQ55489238
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural GeneQ56591978
Pertussis toxin triggers rapid second messenger production in human T lymphocytesQ70038268
Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87)Q71257950
Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalizationQ73836239
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
membrane proteinQ423042
cell surface receptorQ2476074
cellQ7868
virus receptorsQ66053321
hemic and immune systemsQ70202933
P304page(s)591-595
P577publication date1999-09-01
1999-09-06
P1433published inJournal of Experimental MedicineQ3186912
P1476titleInterference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes
P478volume190

Reverse relations

cites work (P2860)
Q40621689Cell-Free HIV Type 1 Infection is Restricted in the Human Trophoblast Choriocarcinoma BeWo Cell Line, Even with Expression of CD4, CXCR4 and CCR5
Q34731197Chemokine receptors on dendritic cells promote autoimmune reactions
Q34234127Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors
Q35027627Interactions between opioid and chemokine receptors: heterologous desensitization
Q74121926Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of CD14 and urokinase receptor
Q39732524Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages
Q42824844Poxvirus infection rapidly activates tyrosine kinase signal transduction
Q35022576Slit proteins, potential endogenous modulators of inflammation
Q35741691The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages
Q38292250Truncation of NH2-terminal amino acid residues increases agonistic potency of leukotactin-1 on CC chemokine receptors 1 and 3.

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