The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains

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The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.190.5.597
P932PMC publication ID2195621
P698PubMed publication ID10477545
P5875ResearchGate publication ID12821670

P50authorMassimo AlfanoQ73268464
P2093author name stringH Schmidtmayerova
M Bukrinsky
T Pushkarsky
C A Amella
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface moleculesQ28246564
Pertussis toxin and target eukaryotic cells: binding, entry, and activationQ28269020
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
Pertussis toxin triggers rapid second messenger production in human T lymphocytesQ70038268
Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTKQ74106115
Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120Q28287967
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotypeQ28646874
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G proteinQ30459108
Evidence that lipopolysaccharide and pertussis toxin bind to different domains on the same p73 receptor on murine splenocytesQ33619945
Bacterial toxins affect early events of T lymphocyte activationQ34564560
G proteinsQ35557485
Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytesQ35888738
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domainsQ36186612
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transductionQ36324324
Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirusQ36352167
Change in coreceptor use correlates with disease progression in HIV-1--infected individualsQ36376800
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.Q36380882
Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.Q36401415
Pertussis toxin has eukaryotic-like carbohydrate recognition domainsQ36759213
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activityQ36765049
The 70-kilodalton pertussis toxin-binding protein in Jurkat cells.Q38307893
Pharmacology of pertussis toxin B-oligomerQ38358142
The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaqueQ38501268
HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.Q38869431
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptorQ38878235
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionQ38949380
HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.Q39000361
Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulationQ39036696
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entryQ39464591
Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: replication is restricted at a postentry levelQ39580343
Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells.Q39581009
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptorQ39585768
Lymphocyte receptors for pertussis toxin.Q40429107
Chemokine receptors and human immunodeficiency virus infectionQ41667150
Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin.Q41728052
Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxisQ42951587
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line JurkatQ43525127
Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infectionQ45854138
HIV-1 subtype and second-receptor useQ59068400
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)597-605
P577publication date1999-09-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleThe B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains
P478volume190

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