Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

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Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse is …
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scholarly articleQ13442814

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P356DOI10.3389/FNANA.2014.00042
P8608Fatcat IDrelease_a5kitmmme5gb7cza2eilfjjkli
P932PMC publication ID4051274
P698PubMed publication ID24959122
P5875ResearchGate publication ID263432585

P50authorLucy VulchanovaQ55708881
R Scott McIvorQ114401924
Lalitha R BelurQ114401927
P2093author name stringCarolyn A Fairbanks
Maureen S Riedl
Daniel J Schuster
Kelley F Kitto
Robert P Elde
Jaclyn A Dykstra
P2860cites workMicroglia-specific localisation of a novel calcium binding protein, Iba1Q28273977
Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responsesQ30531601
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapyQ30541880
Comparison of AAV serotypes for gene delivery to dorsal root ganglion neuronsQ33822237
Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar punctureQ33975660
Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice.Q34321271
Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndromeQ34365749
Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injectionQ34770058
Terminal N-linked galactose is the primary receptor for adeno-associated virus 9.Q34787342
Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brainQ35000819
The AAV9 receptor and its modification to improve in vivo lung gene transfer in miceQ35015807
Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primatesQ35086714
Spinal delivery of analgesics in experimental models of pain and analgesiaQ35205465
Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I.Q35559945
Genetic tracing of Nav1.8-expressing vagal afferents in the mouseQ35837465
Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primatesQ35892068
Glycan binding avidity determines the systemic fate of adeno-associated virus type 9.Q36276561
Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic painQ36458975
Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic fociQ36493030
Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primatesQ36745664
Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primatesQ36848703
Multiplicity of cerebrospinal fluid functions: New challenges in health and diseaseQ37163564
Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of deliveryQ37355740
Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injuryQ37562075
AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transductionQ37571781
Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice.Q37696025
The advent of AAV9 expands applications for brain and spinal cord gene deliveryQ38004089
Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transferQ39566137
Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.Q41080089
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineageQ41183035
Correction of neurological disease of mucopolysaccharidosis IIIB in adult mice by rAAV9 trans-blood-brain barrier gene deliveryQ42059455
Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal hornQ42177229
Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cordQ42257686
Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neuronsQ42263324
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression.Q42925040
AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injectionQ44655971
Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brainQ44686125
Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs.Q44899252
Transgene expression and effective gene silencing in vagal afferent neuronsin vivousing recombinant adeno-associated virus vectorsQ45373500
Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene deliveryQ45868795
Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult miceQ45879078
Clearance of albumin from mouse subarachnoid space: a measure of CSF bulk flowQ70520829
Intrathecal substance P elicits a caudally-directed biting and scratching behavior in miceQ72640892
P921main subjectvector-borne diseaseQ2083837
P304page(s)42
P577publication date2014-06-10
P1433published inFrontiers in NeuroanatomyQ1893158
P1476titleBiodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse
P478volume8

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cites work (P2860)
Q64287660A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice
Q91781812A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna
Q36352399A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord.
Q57165754A bright future? Optogenetics in the periphery for pain research and therapy
Q50015658A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.
Q100430604AAV9 Gene Therapy Increases Lifespan and Treats Pathological and Behavioral Abnormalities in a Mouse Model of CLN8-Batten Disease
Q36588788AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice
Q38826941Adeno-Associated Viral Vector Delivery to the Enteric Nervous System: A Review
Q92069614Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation
Q38703339Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration
Q54944159Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents.
Q47102617Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice.
Q49874005Advances in spinal muscular atrophy therapeutics
Q90305369Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models
Q55339450Autism spectrum disorder: prospects for treatment using gene therapy.
Q59354904Cerebrospinal Fluid-Directed rAAV9-rsATP7A Plus Subcutaneous Copper Histidinate Advance Survival and Outcomes in a Menkes Disease Mouse Model
Q36543422Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease
Q35658521Current gene therapy using viral vectors for chronic pain
Q38761724Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery
Q40235080Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders
Q27318087Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII.
Q90205161Fetal Gene Therapy Using a Single Injection of Recombinant AAV9 Rescued SMA Phenotype in Mice
Q38941931Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome.
Q92089380Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease
Q94503876Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9
Q47558790Gene therapy for Mucopolysaccharidoses.
Q45872420Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
Q40611143Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies
Q40228879Improved gene delivery to adult mouse spinal cord through the use of engineered hybrid adeno-associated viral serotypes.
Q94476154Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?
Q34341997Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice
Q95935116Intravenous delivery for treatment of mucopolysaccharidosis type I: A comparison of AAV serotypes 9 and rh10
Q41921977In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.
Q92615014MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
Q89879783Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases
Q43113417Neuroanatomy and transgenic technologies.
Q64082902On the development of optical peripheral nerve interfaces
Q92522172Optogenetic recruitment of spinal reflex pathways from large-diameter primary afferents in non-transgenic rats transduced with AAV9/Channelrhodopsin 2
Q59137624Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
Q92487813Progress and challenges of gene therapy for Pompe disease
Q41126219Proof-of-concept: neonatal intravenous injection of adeno-associated virus vectors results in successful transduction of myenteric and submucosal neurons in the mouse small and large intestine
Q54245962Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space.
Q38811165Stacking up CRISPR against RNAi for therapeutic gene inhibition
Q37351327Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.
Q26767363Targeted approaches to induce immune tolerance for Pompe disease therapy
Q38963728Targeting the gastrointestinal tract with viral vectors: state of the art and possible applications in research and therapy
Q38737932Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology
Q38746238Viral vectors for therapy of neurologic diseases