Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

scientific article published on 14 November 2018

Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIADV.AAU9859
P932PMC publication ID6235539
P698PubMed publication ID30443600

P50authorMark H. TuszynskiQ21856455
Michael J CastleQ57021514
Aravind AsokanQ91787026
P2093author name stringYuhsiang Cheng
P2860cites workGene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialQ28296434
Sleep drives metabolite clearance from the adult brainQ29620065
Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cellsQ33584088
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's diseaseQ33726762
Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouseQ33732656
Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar punctureQ33975660
Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic miceQ34651703
Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primatesQ35086714
Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primatesQ35153080
Gene therapy for pain: results of a phase I clinical trialQ35154100
The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputsQ35420341
Stereological estimates of the basal forebrain cell population in the rat, including neurons containing choline acetyltransferase, glutamic acid decarboxylase or phosphate-activated glutaminase and colocalizing vesicular glutamate transportersQ35697190
Differential expression of CaMKII isoforms and overall kinase activity in rat dorsal root ganglia after injuryQ35798313
Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primatesQ35892068
Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primatesQ36745664
Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primatesQ36848703
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic miceQ37196325
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brainQ37277317
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brainQ37382030
Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of catsQ39415889
Evaluation of intrathecal routes of administration for adeno-associated virus vectors in large animals.Q40083638
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systemsQ40137101
Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disordersQ40235080
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.Q40693796
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.Q40906363
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brainQ44686125
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.Q45324243
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.Q45859568
Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate ratsQ45872026
Single-Dose Gene-Replacement Therapy for Spinal Muscular AtrophyQ45873849
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseQ45883058
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeysQ48325968
Arterial vascularisation of the anterior perforated substance.Q49086405
The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice.Q50083826
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)eaau9859
P577publication date2018-11-14
P1433published inScience AdvancesQ19881044
P1476titlePhysical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
P478volume4

Reverse relations

cites work (P2860)
Q92666846AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice
Q90002291Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery
Q64245388The Application of Adeno-Associated Viral Vector Gene Therapy to the Treatment of Fragile X Syndrome

Search more.