NextGen protein design

scientific article

NextGen protein design is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BST20130112
P932PMC publication ID4051282
P698PubMed publication ID24059497
P5875ResearchGate publication ID256982726

P50authorLynne ReganQ4814622
P2093author name stringNicholas Sawyer
Elizabeth B Speltz
P2860cites workDesign of Stable α-Helical Arrays from an Idealized TPR MotifQ27641184
High-affinity single-domain binding proteins with a binary-code interfaceQ27644389
A designed ankyrin repeat protein evolved to picomolar affinity to Her2Q27644627
Structure of wild-type Plk-1 kinase domain in complex with a selective DARPinQ27650241
Design of protein function leaps by directed domain interface evolutionQ27650480
A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein InterfacesQ27651036
Redesign of a protein - peptide interaction: Characterization and applicationsQ27654279
Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldQ27676439
Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineeringQ27677231
Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target ProteinQ27677469
WW and SH3 domains, two different scaffolds to recognize proline-rich ligandsQ28209648
High-affinity binders selected from designed ankyrin repeat protein librariesQ28257550
Recognition of unique carboxyl-terminal motifs by distinct PDZ domainsQ29547580
SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef.Q30175321
Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.Q30341679
Recombinant human factor VIII-specific affinity ligands selected from phage-displayed combinatorial libraries of protein A.Q30698098
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.Q30979207
CIS display: In vitro selection of peptides from libraries of protein-DNA complexesQ31049812
Directed evolution of high-affinity antibody mimics using mRNA displayQ31106575
Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteinsQ31162756
The fibronectin type III domain as a scaffold for novel binding proteinsQ31962422
Tumor imaging using a picomolar affinity HER2 binding affibody moleculeQ33240101
Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shufflingQ33349284
High-affinity lamprey VLRA and VLRB monoclonal antibodiesQ33485795
Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsisQ33509524
Phase I and pharmacokinetic study of CT-322 (BMS-844203), a targeted Adnectin inhibitor of VEGFR-2 based on a domain of human fibronectinQ34158482
A combinatorial library of an alpha-helical bacterial receptor domainQ34368637
Designed Armadillo repeat proteins: library generation, characterization and selection of peptide binders with high specificity.Q34417035
Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domainQ34435244
Selection of a high-affinity WW domain against the extracellular region of VEGF receptor isoform-2 from a combinatorial library using CIS displayQ34573507
DARPins: a new generation of protein therapeutics.Q34795228
68Ga-DOTA-affibody molecule for in vivo assessment of HER2/neu expression with PETQ36085489
Structure and specificity of lamprey monoclonal antibodies.Q36890908
A modular approach to the design of protein-based smart gelsQ39397597
All repeats are not equal: a module-based approach to guide repeat protein designQ39462698
In vitro characterization of a bivalent anti-HER-2 affibody with potential for radionuclide-based diagnosticsQ40403332
Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II studyQ45148015
Design of an optimized scaffold for affibody moleculesQ45323800
Characterization and further stabilization of designed ankyrin repeat proteins by combining molecular dynamics simulations and experimentsQ46874746
Computer-aided design of a PDZ domain to recognize new target sequences.Q52037989
Designed TPR modules as novel anticancer agentsQ80920492
P433issue5
P921main subjectprotein designQ410814
P304page(s)1131-1136
P577publication date2013-10-01
P1433published inBiochemical Society TransactionsQ864226
P1476titleNextGen protein design
P478volume41

Reverse relations

cites work (P2860)
Q38620529A designed repeat protein as an affinity capture reagent
Q30360904CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Q50797554Designed Proteins as Novel Imaging Reagents in Living Escherichia coli.
Q38302293Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.
Q35575065Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage
Q50107904PyFolding: Open-Source Graphing, Simulation, and Analysis of the Biophysical Properties of Proteins
Q38141055Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.
Q38827102The future of protein scaffolds as affinity reagents for purification.

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