Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression

scientific article

Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E04-12-1082
P932PMC publication ID1073670
P698PubMed publication ID15689487

P50authorValerie M WeaverQ67221999
P2093author name stringSarah E Robertson
Karen D Cowden Dahl
M Celeste Simon
P2860cites workActivation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?Q24561702
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?Q37366512
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.Q38315198
Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoterQ38333714
Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWoQ40589869
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.Q40633683
Expression of cell adhesion molecules in murine placentas and a placental cell lineQ40827744
Integrin expression in human melanoma cells with differing invasive and metastatic propertiesQ41638856
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancerQ42481577
ARNT-deficient mice and placental differentiationQ43703428
Expression, regulation, and function of alpha V integrins in hepatocellular carcinoma: an in vivo and in vitro studyQ44080054
Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cellsQ44116702
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.Q52195684
Integrin trafficking regulates adhesion to fibronectin during differentiation of mouse peri-implantation blastocystsQ58803684
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1Q63565692
Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinomaQ71379886
Beta 1- and beta 3-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts. Regulation by ligand-induced mobilization of stored receptorQ71692356
Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2Q73205748
Hypoxia induces differential expression of the integrin receptors alpha(vbeta3) and alpha(vbeta5) in cultured human endothelial cellsQ73911982
Intratumoral oxygen tension in metastatic melanomaQ74040495
Alphav integrins mediate adhesion and migration of breast carcinoma cell linesQ74313522
Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cellsQ74525502
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic developmentQ24595910
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular developmentQ24681396
Integrin signalingQ28142010
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alphaQ28259513
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrinsQ28289706
Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migrationQ28507241
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature miceQ28508637
58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminaseQ28570016
HIF-1 alpha is required for solid tumor formation and embryonic vascularization.Q28588778
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alphaQ28591038
Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cellsQ28591734
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodelingQ28592049
Developmental regulation of integrin expression at the time of implantation in the mouse embryoQ28593415
Promotion of trophoblast stem cell proliferation by FGF4Q29614847
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Q29615241
HIF-1alpha is essential for myeloid cell-mediated inflammationQ29617581
The PAS superfamily: sensors of environmental and developmental signalsQ29622907
Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryoQ30308507
Mechanisms of implantation in the mouse: differentiation and functional importance of trophoblast giant cell behaviorQ30310926
Why do so many stimuli induce tyrosine phosphorylation of FAK?Q33784269
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.Q33835366
Vascular function in preeclampsia.Q33951685
Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapyQ34275617
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydratesQ34332106
Regulation of trophoblast invasion: from normal implantation to pre-eclampsiaQ34623467
Multilineage embryonic hematopoiesis requires hypoxic ARNT activityQ35207418
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responsesQ35209175
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancerQ35578323
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectinQ35606876
An unexpected role for hypoxic response: oxygenation and inflammationQ35623785
Integrins: roles in cancer development and as treatment targetsQ35647842
HIF at the crossroads between ischemia and carcinogenesisQ35770296
Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesisQ36640851
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expressionQ36672331
P433issue4
P921main subjecthypoxiaQ105688
P304page(s)1901-1912
P577publication date2005-02-02
P1433published inMolecular Biology of the CellQ2338259
P1476titleHypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression
P478volume16

Reverse relations

cites work (P2860)
Q33936945A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition
Q35207572Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy
Q38288371An Integrin-Targeting RGDK-Tagged Nanocarrier: Anticancer Efficacy of Loaded Curcumin
Q33926952An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Q45986472Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
Q39973056Canstatin gene electrotransfer combined with radiotherapy: preclinical trials for cancer treatment
Q36290081Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts
Q37631589Cell adhesion molecules: role and clinical significance in cancer
Q36621149Cobalt chloride inhibits tumor formation in osteosarcoma cells through upregulation of HIF-1α
Q35763195Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis
Q40320858Differential effects of cytohesins 2 and 3 on beta1 integrin recycling.
Q39462744Dynamic alterations in integrin α4 expression by hypoxia are involved in trophoblast invasion during early implantation
Q34599786ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement
Q48004345Engineered myocardium model to study the roles of HIF-1α and HIF1A-AS1 in paracrine-only signaling under pathological level oxidative stress
Q47096520Evaluating the Usefulness of a Novel 10B-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy
Q41670915Exploring the Role of RGD-Recognizing Integrins in Cancer
Q30539170HIF1α and HIF2α independently activate SRC to promote melanoma metastases
Q37992688Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success
Q28281337Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells
Q41015404Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis
Q36157832Hypoxia and HIFs in regulating the development of the hematopoietic system
Q89834942Hypoxia and Placental Development
Q100694543Hypoxia and proangiogenic proteins in human ameloblastoma
Q38989120Hypoxia and the modulation of the actin cytoskeleton - emerging interrelations
Q39556460Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface
Q35178270Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation
Q47916975Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary-like tube formation
Q39144797Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis
Q38108833Hypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases
Q28585983Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation
Q37629893Hypoxia-inducible factors in stem cells and cancer
Q40098490In vivo imaging of tumour angiogenesis in mice with the alpha(v)beta (3) integrin-targeted tracer 99mTc-RAFT-RGD.
Q37845642Influence of stress on extracellular matrix and integrin biology.
Q39096530Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
Q28066805Integrins in the Spotlight of Cancer
Q91743168Integrins: Moonlighting Proteins in Invadosome Formation
Q44411444Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update
Q40257917Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells
Q34646945LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia
Q42572026Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice
Q41626926Low thyroid hormone levels improve survival in murine model for ocular melanoma
Q42009996Mechanical characterization of adult stem cells from bone marrow and perivascular niches
Q37615286Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking?
Q39959902Multifunctional polymeric micelles for enhanced intracellular delivery of doxorubicin to metastatic cancer cells
Q35605710Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis
Q38217758Osteopontin as a therapeutic target for cancer
Q26824421Oxygen levels and the regulation of cell adhesion in the nervous system: a control point for morphogenesis in development, disease and evolution?
Q36757465Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease
Q56887737Physiological Hypoxia (Physioxia) Impairs the Early Adhesion of Single Lymphoma Cell to Marrow Stromal Cell and Extracellular Matrix. Optical Tweezers Study
Q40737024Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation.
Q36513149Progesterone and interferon tau regulate hypoxia-inducible factors in the endometrium of the ovine uterus.
Q35826582Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1alpha-mediated tumor apoptotic switch
Q37660895Regulation of cell signalling by uPAR.
Q64999397Role of glycosylation in hypoxia-driven cell migration and invasion.
Q35879045Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, hypoxia-inducible factor 1α, a disintegrin and metalloproteinase 12, and heparin-binding epidermal growth factor.
Q34286796Targeted genes and interacting proteins of hypoxia inducible factor-1.
Q60916221Tetrac Delayed the Onset of Ocular Melanoma in an Orthotopic Mouse Model
Q28728396The hTERT promoter enhances the antitumor activity of an oncolytic adenovirus under a hypoxic microenvironment
Q37111021Three-dimensional context regulation of metastasis
Q33390467Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas
Q38396834αv-Integrin isoform expression in primary human tumors and brain metastases

Search more.