Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

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Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI119387
P3181OpenCitations bibliographic resource ID1794291
P932PMC publication ID508044
P698PubMed publication ID9151786

P2093author name stringY Zhou
S J Fisher
O Genbacev
C H Damsky
E Dejana
M Janatpour
M Wheelock
P2860cites workDiversity of the cadherin family: evidence for eight new cadherins in nervous tissueQ24337166
A novel endothelial-specific membrane protein is a marker of cell-cell contactsQ24642987
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assemblyQ24657591
Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during developmentQ24678731
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Cell adhesion: the molecular basis of tissue architecture and morphogenesisQ28276573
Morphogenetic roles of classic cadherinsQ29614941
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vesselsQ29619679
Requirement of vascular integrin alpha v beta 3 for angiogenesisQ29619681
Isolation and purification of microvascular endothelium from human decidual tissue in the late phase of pregancyQ33341324
Implantation and the placenta: key pieces of the development puzzleQ33367178
Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblastsQ33893072
Involvement of integrin alpha V gene expression in human melanoma tumorigenicityQ34222036
Integrin switching regulates normal trophoblast invasionQ34293110
VasculogenesisQ34387300
Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivoQ35596525
Adhesive and degradative properties of human placental cytotrophoblast cells in vitroQ36221270
The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin)Q36235299
92-kD type IV collagenase mediates invasion of human cytotrophoblastsQ36529534
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsiaQ37350668
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?Q37366512
Current topic: pre-eclampsia and the placentaQ37492460
E-cadherin as a tumor (invasion) suppressor geneQ40523997
Extracellular matrix 5: adhesive interactions in early mammalian embryogenesis, implantation, and placentationQ40773858
Expression and inducibility of vascular adhesion receptors in development.Q41332769
Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placentaQ41385756
A class I antigen, HLA-G, expressed in human trophoblastsQ41737375
Anatomical aspects of implantationQ42125498
Early stages of trophoblastic invasion of the maternal vascular system during implantation in the macaque and baboonQ42469220
Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro.Q42484777
Immunohistochemical localization of vascular endothelial growth factor in the human placentaQ42520710
Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissueQ44798802
Trophoblastic invasion and the development of uteroplacental arteries in the macaque: immunohistochemical localization of cytokeratins, desmin, type IV collagen, laminin, and fibronectinQ46874330
Trophoblastic invasion and modification of uterine veins during placental development in macaquesQ46941126
Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.Q52208921
Catenin-dependent and -independent Functions of Vascular Endothelial CadherinQ59282003
Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancyQ61484920
Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progressionQ68547014
Soluble 80-kd fragment of cell-CAM 120/80 disrupts cell-cell adhesionQ69140550
Cell-specific metallothionein gene expression in mouse decidua and placentaeQ69426224
Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation stepsQ71735196
Development and structure of the human placenta from the end of the 3rd month of gestationQ72214464
Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblastQ72297496
Immunoelectron characterisation of the inter-endothelial junctions of human term placentaQ72789209
The anatomy of the maternal side of the placentaQ72873414
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)2139-51
P577publication date1997-05-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleHuman cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?
P478volume99

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cites work (P2860)
Q366735965-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo
Q51903620A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation.
Q52552806A novel in vitro model of trophoblast-mediated decidual blood vessel remodeling.
Q40107144A novel three-dimensional in vitro system to study trophoblast-endothelium cell interactions.
Q35745811A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation
Q41684338A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation
Q34258271A review of trafficking and activation of uterine natural killer cells
Q35057672A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia
Q44327248A role for alphavbeta3 integrin during implantation in the rabbit model
Q42500317A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta
Q28139978A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells
Q51336360A systematic approach to the development of a safe live attenuated Zika vaccine.
Q38010711A variety of opportunities for immune interactions during trophoblast development and invasion.
Q40616036ACOG technology assessment. Genetics and molecular diagnostic testing. Number 1, July 2002. American College of Obstetrics and Gynecology
Q36751530ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.
Q61873092ADAM8 localizes to extravillous trophoblasts within the maternal-fetal interface and potentiates trophoblast cell line migration through a β1 integrin-mediated mechanism
Q36824901AT1, AT2, and AT(1-7) receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy
Q50778864Aberrant placenta gene expression pattern in bovine pregnancies established after transfer of cloned or in vitro produced embryos.
Q47175696Aberrant processing of plasma vitronectin and high-molecular-weight kininogen precedes the onset of preeclampsia
Q46491999Abnormal Placentation Associated with Infertility as a Marker of Overall Health
Q37248439Accumulation of uterine CD16(-) natural killer (NK) cells: friends, foes, or Jekyll-and-Hyde relationship for the conceptus?
Q35221788Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor
Q24674988Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast
Q33330007Affinity purified human antiphospholipid antibodies bind normal term placenta
Q73492106Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: indicators of disturbed placentation in absence of evidence of endothelial dysfunction?
Q47169552Amniotic Fluid Arginine from Gestational Weeks 13 to 15 Is a Predictor of Birth Weight, Length, and Head Circumference
Q24298379An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development
Q36938141An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling
Q36287399Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia
Q34714082Angiogenic factors and preeclampsia
Q36526596Angiogenic factors in preeclampsia and related disorders
Q36339288Angiogenic factors in the pathogenesis of preeclampsia
Q33908967Angiogenin expression during early human placental development; association with blood vessel formation
Q35699115Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
Q33441187Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model
Q28213303Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules
Q26999710Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment
Q29147510Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion
Q42489800Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic milieu in cultured cytotrophoblast cells
Q35681804Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
Q35171667Autoimmune disease as a cause of reproductive failure
Q38836115Benzo(a)pyrene inhibits migration and invasion of extravillous trophoblast HTR-8/SVneo cells via activation of the ERK and JNK pathway
Q33835366Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.
Q36752130Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia
Q37156676Biomarkers for the management of pre-eclampsia in pregnant women.
Q51976566Cadherins in maternal-foetal interactions: red queen with a green beard?
Q24294977Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development
Q36544044Calcium homeostasis in human placenta: role of calcium-handling proteins
Q37406706Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents
Q52611946Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice.
Q33901191Cellular and molecular regulation of spiral artery remodelling: lessons from the cardiovascular field
Q33801683Chapter 12. Placental remodeling of the uterine vasculature
Q74509509Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta
Q28208656Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells
Q34996675Collagen type IV at the fetal-maternal interface.
Q37237709Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas
Q37638376Complement activation and pregnancy failure
Q39182724Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26.
Q28218814Control of human trophoblast function
Q34258295Coordinate Regulation of Lymphocyte-Endothelial Interactions by Pregnancy-Associated Hormones
Q35070793Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation
Q40602864Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction
Q34280644Critical growth factors and signalling pathways controlling human trophoblast invasion
Q60047012Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
Q90514495Current Anti-HPA-1a Standard Antibodies React with the β3 Integrin Subunit but not with αIIbβ3 and αvβ3 Complexes
Q33441520Current perspectives on fetal and neonatal alloimmune thrombocytopenia - increasing clinical concerns and new treatment opportunities
Q36355613Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model
Q73400011Cytotrophoblasts: masters of disguise
Q37361953DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts.
Q52010655Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.
Q37149069Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia
Q37077537Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium
Q35227748Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia
Q28207790Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors
Q73320492Detection of placental growth hormone variant and chorionic somatomammotropin-L RNA expression in normal and diabetic pregnancy by reverse transcriptase-polymerase chain reaction
Q38184164Development of the hemochorial maternal vascular spaces in the placenta through endothelial and vasculogenic mimicry
Q98302973Developmental potential of aneuploid human embryos cultured beyond implantation
Q35857373Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta
Q34102747Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
Q35743580Differential Effects of Sodium Butyrate and Lithium Chloride on Rhesus Monkey Trophoblast Differentiation
Q92890550Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains
Q33806626Differential methylation of genes associated with cell adhesion in preeclamptic placentas.
Q35155618Discovery of a cell: reflections on the checkered history of intermediate trophoblast and update on its nature and pathologic manifestations
Q35599094Disorders of the fetomaternal unit: hematologic manifestations in the fetus and neonate
Q34731047Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia
Q37462447Diverse functions of HBEGF during pregnancy.
Q89461646Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization
Q35818449Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia
Q51075847E-selectin expression and function in a unique placental trophoblast population at the fetal-maternal interface: regulation by a trophoblast-restricted transcriptional mechanism conserved between humans and mice.
Q28384159Effect of Bisphenol A on invasion ability of human trophoblastic cell line BeWo
Q36825271Endoglin: a critical mediator of cardiovascular health
Q35698707Endothelial cell hyperproliferation and stratification in uteroplacental blood vessels of the black mastiff bat, Molossus rufus
Q35079406Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
Q37109332Epithelial-mesenchymal transition during extravillous trophoblast differentiation.
Q28067753Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
Q34031959Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis
Q39507002Establishment of human trophoblast progenitor cell lines from the chorion
Q93163214Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts
Q38979136Establishment of the Human Uteroplacental Circulation: A Historical Perspective
Q36455267Estradiol Elicits Proapoptotic and Antiproliferative Effects in Human Trophoblast Cells
Q56449490Evaluation of inflammatory mediators in the deciduas of pregnant women with pre-eclampsia/eclampsia
Q35048713Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia
Q36535966Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry
Q52100421Expression and secretion of the vascular cell adhesion molecule-1 in human placenta and its decrease in fetal growth restriction.
Q58197425Expression of E-cadherin and its repressor Snail in placental tissue of normal, preeclamptic and HELLP pregnancies
Q55270146Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site: Implications for Preeclampsia, Spontaneous Abortion, and Intrauterine Growth Restriction.
Q44809214Expression of alphav, alpha4, alpha5 and beta3 integrin subunits, fibronectin and vitronectin in goat peri-implantation
Q34979775Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry
Q40604750Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells
Q80435064Expression of the blood-group-related antigens Sialyl Lewis a, Sialyl Lewis x and Lewis y in term placentas of normal, preeclampsia, IUGR- and HELLP-complicated pregnancies
Q78760813Expression of the high-mobility group protein HMGI(Y) in human trophoblast: potential role in trophoblast invasion of maternal tissue
Q28289706Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
Q36026812Extravillous trophoblast and decidual natural killer cells: a remodelling partnership.
Q35163753Factors regulating trophoblast migration and invasiveness: possible derangements contributing to pre-eclampsia and fetal injury
Q39238961Feeding Your Baby In Utero: How the Uteroplacental Circulation Impacts Pregnancy.
Q48031180Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies
Q35918344Feto-maternal immune interaction at the placental level.
Q35849581Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells
Q34476756Functional regulation of human trophoblast differentiation
Q42465854Gestational age-dependent extravillous cytotrophoblast osteopontin immunolocalization differentiates between normal and preeclamptic pregnancies
Q52650367Gestational bisphenol S impairs placental endocrine function and the fusogenic trophoblast signaling pathway.
Q37673149HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex
Q40862721HLA-G inhibits the transendothelial cell migration of human NK cells: a strategy for inhibiting xenograft rejection
Q35190892HLA-G, pre-eclampsia, immunity and vascular events
Q35134502Haemostatic mechanisms in human placenta
Q28204797Heme Oxygenases in Pregnancy II: HO‐2 is Downregulated in Human Pathologic Pregnancies
Q57177754Hemochorial placentation: development, function, and adaptations
Q40596618Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Q35041440Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide
Q33806360Histopathologies, immunolocalization, and a glycan binding screen provide insights into Plasmodium falciparum interactions with the human placenta
Q34446646Human cytomegalovirus infection dysregulates the canonical Wnt/β-catenin signaling pathway
Q33808573Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis
Q36510278Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro
Q34227634Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
Q46064223Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype
Q46130400Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C
Q91719656Human placenta and trophoblast development: key molecular mechanisms and model systems
Q33581645Human placental microRNAs and preeclampsia
Q37199588Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling.
Q36462510Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification
Q35842147Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction
Q38074928Human trophoblast progenitors: where do they reside?
Q24306183Hypoxia up-regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts
Q91968277Hypoxia-induced Downregulation of SRC-3 Suppresses Trophoblastic Invasion and Migration Through Inhibition of the AKT/mTOR Pathway: Implications for the Pathogenesis of Preeclampsia
Q33734575Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression
Q33939664Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
Q40756189Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat.
Q27009441If we know so much about preeclampsia, why haven't we cured the disease?
Q36662338Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
Q36725906In vitro and in vivo evidence for lack of endovascular remodeling by third trimester trophoblasts.
Q82950530In vitro spheroid model of placental vasculogenesis: does it work?
Q37630076Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function.
Q89860687Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia
Q74234864Influence of the human endogenous retrovirus-like element HERV-E.PTN on the expression of growth factor pleiotrophin: a critical role of a retroviral Sp1-binding site
Q33853208Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.
Q36912340Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation
Q38991662Integrin α8 Is Abundant in Human, Rat, and Mouse Trophoblasts
Q33199751Interaction of cocultured decidual endothelial cells and cytotrophoblasts in preeclampsia.
Q77707578Interaction of interstitial trophoblast with placental bed capillaries and venules of normotensive and pre-eclamptic pregnancies
Q33766409Interleukin 11 inhibits human trophoblast invasion indicating a likely role in the decidual restraint of trophoblast invasion during placentation.
Q36857971Intrauterine trophoblast migration: A comparative view of humans and rodents
Q54394520Kisspeptin/KISS1R signaling potentiates extravillous trophoblast adhesion to type-I collagen in a PKC- and ERK1/2-dependent manner.
Q34646945LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia
Q35547012Life Cycle of Decidual Cells
Q36767568Local and systemic factors and implantation: what is the evidence?
Q38698740Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro.
Q36002985MUC1 is involved in trophoblast transendothelial migration
Q46328097Macaque trophoblast migration is regulated by RANTES.
Q24302083Magic roundabout, a tumor endothelial marker: expression and signaling
Q33332320Management of severe alloimmune thrombocytopenia in the newborn
Q73642484Marginal transfer of ReoPro (Abciximab) compared with immunoglobulin G (F105), inulin and water in the perfused human placenta in vitro
Q35088214Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
Q36494058Maternal hypoxia activates endovascular trophoblast cell invasion
Q35629442Maternal neoangiogenesis during pregnancy partly derives from fetal endothelial progenitor cells.
Q36990967Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction
Q55231005Mechanism of maternal vascular remodeling during human pregnancy.
Q36577103Mechanisms of disease: Pre-eclampsia
Q90643526MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling
Q36790358MicroRNAs in Human Placental Development and Pregnancy Complications
Q59333215Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia
Q37538164Models for study of human embryo implantation: choice of cell lines?
Q89812634Molecular and cellular underpinnings of normal and abnormal human placental blood flows
Q24800983Molecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells
Q35842085Molecular determinants of ovarian cancer plasticity
Q33344105Molecular mechanisms of preeclampsia
Q36360384N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility
Q48134839N-cadherin knockdown leads to disruption of trophoblastic and endothelial cell interaction in a 3D cell culture model - New insights in trophoblast invasion failure
Q36294742N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
Q90382714Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas
Q33993285Noninvasive and quantitative assessment of in vivo fetomaternal interface angiogenesis using RGD-based fluorescence.
Q36135078Notch signaling pathway and human placenta
Q37473736Notch1 controls development of the extravillous trophoblast lineage in the human placenta.
Q37465594Novel approaches for mechanistic understanding and predicting preeclampsia
Q50041471Obesity and high fat diet induce distinct changes in placental gene expression and pregnancy outcome.
Q24681648Overexpression of carcinoma and embryonic cytotrophoblast cell-specific Mig-7 induces invasion and vessel-like structure formation
Q37155806Oxygen modulates human decidual natural killer cell surface receptor expression and interactions with trophoblasts
Q46462966Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia
Q37543521Oxygen: a master regulator of pancreatic development?
Q35693520Pathogens and the placental fortress
Q26865332Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology
Q24649934Pathophysiology of placentation abnormalities in pregnancy-induced hypertension
Q38796954Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction
Q36742274Pathophysiology of tumor neovascularization
Q33848380Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor
Q24650730Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells
Q90397386Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates
Q37079540Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements.
Q37451544Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia
Q35196227Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey
Q33527000Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes
Q34908922Placentation abnormalities in the pathophysiology of preeclampsia
Q34173981Placentation, antiphospholipid syndrome and pregnancy outcome
Q28343517Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro
Q58778301Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia
Q36500617Positive selection in the evolution of cancer
Q36857964Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta.
Q33419126Pre-eclampsia has an adverse impact on maternal and fetal health
Q47304850Pre-eclampsia is associated with the failure of melanoma cell adhesion molecule (MCAM/CD146) expression by intermediate trophoblast
Q77321024Pre-eclampsia: a disorder of placental mitochondria?
Q35911954Pre-eclampsia: is it all in the placenta?
Q91815900Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Q37362662Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection
Q37428029Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2.
Q34920271Preeclampsia and the Anti-Angiogenic State
Q37366512Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?
Q35787199Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall
Q33597119Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions
Q37723245Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state
Q37512886Preeclampsia: the role of angiogenic factors in its pathogenesis
Q33858363Preeclampsia: what we know and what we do not know
Q52717823Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia.
Q37879823Pregnancy-associated homeostasis and dysregulation: lessons from genetically modified animal models
Q34229262Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins
Q38994831Presence of Telocytes in a Non-innervated Organ: The Placenta
Q47674689Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia
Q36005842Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro
Q59329268Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment
Q24796713Regulation of trophoblast beta1-integrin expression by contact with endothelial cells
Q34623467Regulation of trophoblast invasion: from normal implantation to pre-eclampsia
Q97524520Renal cell tumors convert natural killer cells to a proangiogenic phenotype
Q30576991Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia
Q39825445Role of EG-VEGF in human placentation: Physiological and pathological implications
Q39247973Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre-eclampsia
Q41718143Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
Q57811281Shifting perspectives from "oncogenic" to oncofetal proteins; how these factors drive placental development
Q35196410Signaling pathways in mouse and human trophoblast differentiation: a comparative review
Q41912386Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface
Q44637309Smoking during pregnancy is associated with alterations in markers of endothelial function
Q28244053Soluble endoglin contributes to the pathogenesis of preeclampsia
Q92710103Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia
Q41132048Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells
Q37218199Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies
Q37089056Targeting cancer stem cells to modulate alternative vascularization mechanisms.
Q34662474Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro
Q35087258The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface
Q92068774The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review
Q54680284The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.
Q35810026The adhesion molecule CEACAM1 (CD66a, C-CAM, BGP) is specifically expressed by the extravillous intermediate trophoblast
Q35037064The biology of preeclampsia
Q33591058The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia
Q34733899The differential expression of Kiss1, MMP9 and angiogenic regulators across the feto-maternal interface of healthy human pregnancies: implications for trophoblast invasion and vessel development
Q48002775The effects of magnesium sulfate on placental vascular endothelial growth factor expression in preeclampsia
Q36875734The feto-maternal interface: setting the stage for potential immune interactions
Q36858003The hydatidiform mole
Q37541519The multidrug-resistance transporter ABCB5 is expressed in human placenta
Q35007371The physiologic and therapeutic role of heparin in implantation and placentation
Q24795491The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia
Q50102668The profiles of soluble adhesion molecules in the "great obstetrical syndromes".
Q34119195The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion
Q36290177The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy.
Q39455660The regulation of trophoblast migration across endothelial cells by low shear stress: consequences for vascular remodelling in pregnancy
Q38532645The role of arginine, homoarginine and nitric oxide in pregnancy
Q37210602The role of decidual natural killer cells in normal placentation and in the pathogenesis of preeclampsia
Q36205605The role of interleukin-1β in human trophoblast motility.
Q41469726The solid state environment orchestrates embryonic development and tissue remodeling
Q35107355The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2
Q34267491The vascular endothelial growth factor family in adverse pregnancy outcomes.
Q41688710The vitronectin receptor plays a role in the adhesion of human cytotrophoblast cells to endothelial cells
Q47304098Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies
Q42505478Tissue kallikrein in human placenta in early and late gestation
Q36091978Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy
Q26829478Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer
Q38742215Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts
Q37311390Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein.
Q24798593Trophoblast 'pseudo-tumorigenesis': significance and contributory factors
Q35889634Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface
Q46258674Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors
Q52613197Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.
Q42623660Trophoblast stem cells
Q37305058Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development
Q35172646Trophoblastic remodeling in normal and preeclamptic pregnancies: implication of cytokines.
Q34390117Trophoblasts, invasion, and microRNA.
Q37056248Tumor-homing peptides as tools for targeted delivery of payloads to the placenta.
Q34460699Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation
Q37682271Up-regulation of CD81 inhibits cytotrophoblast invasion and mediates maternal endothelial cell dysfunction in preeclampsia
Q35868968Uric acid as a pathogenic factor in preeclampsia.
Q37298028Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers
Q34492106Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions.
Q34098892Uteroplacental blood flow. The story of decidualization, menstruation, and trophoblast invasion
Q41581040VE-cadherin Regulates Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Sensitivity to Apoptosis
Q39703856VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers
Q33868524Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma
Q33874221Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry
Q35750283Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
Q30498765Vasculogenic mimicry and tumor angiogenesis
Q35141769Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
Q41696819Vitronectin receptors are expressed by macaque trophoblast cells and play a role in migration and adhesion to endothelium
Q34235439Wnt signalling in implantation, decidualisation and placental differentiation--review
Q43046795Zika Virus Replicates in Proliferating Cells in Explants from First-trimester Human Placentas, Potential Sites for Dissemination of Infection
Q26252081Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission
Q25253584Zika Virus in the Human Placenta and Developing Brain: Cell Tropism and Drug Inhibition
Q74563640[The 2 differentiation pathways of the human trophoblast]
Q52620583miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal.
Q34647008p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state

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