Molecular mechanisms of preeclampsia

scientific article

Molecular mechanisms of preeclampsia is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MVR.2007.04.009
P932PMC publication ID2241748
P698PubMed publication ID17553534
P5875ResearchGate publication ID6282354

P50authorS Ananth KarumanchiQ69022759
P2093author name stringWalter P Mutter
P2860cites workExcessive placental secretion of neurokinin B during the third trimester causes pre-eclampsiaQ22254337
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptorQ24320710
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cellsQ24337230
Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?Q24561702
Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental developmentQ24669641
Circulating levels of immunoreactive cytokines in women with preeclampsiaQ77384781
VASCULAR REACTIVITY TO ANGIOTENSIN II AND NOREPINEPHRINE IN PREGNANT WOMENQ78231835
Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentaeQ78881775
Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsiaQ80496353
Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia developQ80914460
The fetal vascularisation of term human placental villi. I. Peripheral stem villiQ93656368
Expression of inflammatory cytokines in placentas from women with preeclampsiaQ73992120
Oxidative stress and altered endothelial cell function in preeclampsiaQ74757937
Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patientsQ74788028
Obesity and preeclampsia: the potential role of inflammationQ77156957
Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblastsQ28186129
Pre-eclampsia and thrombophiliaQ28196374
What we have learned about preeclampsiaQ28196892
Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2Q28221171
Soluble endoglin contributes to the pathogenesis of preeclampsiaQ28244053
Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic reviewQ28281326
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United StatesQ33349406
Implantation and the placenta: key pieces of the development puzzleQ33367178
High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancyQ33746742
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.Q33930029
Pathogenesis and genetics of pre-eclampsiaQ33934445
Long term mortality of mothers and fathers after pre-eclampsia: population based cohort studyQ33947553
Pre-eclampsiaQ34079933
Hypoxia induces endothelin gene expression and secretion in cultured human endotheliumQ34200622
A study of angiotensin II pressor response throughout primigravid pregnancyQ34512573
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancerQ34530109
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseasesQ34835409
Vascular endothelial growth factor localization in the adult.Q35087955
The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasationQ35157745
Glomerular endothelial cell differentiation.Q36102370
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancerQ36509678
Pre-eclampsia in pregnancy and subsequent risk for breast cancerQ36624347
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?Q37366512
Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohortQ37515561
Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsiaQ38311843
Control of vascular reactivity in pregnancyQ39766605
Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?Q40268212
Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsiaQ40530224
Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective studyQ40802999
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.Q41091104
High plasma cellular fibronectin levels correlate with biochemical and clinical features of preeclampsia but cannot be attributed to hypertension aloneQ41171718
Preeclampsia: an endothelial cell disorderQ41281924
Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placentaQ41385756
Fetal vasculogenesis and angiogenesis in human placental villi.Q42490918
Association of maternal endothelial dysfunction with preeclampsiaQ43553727
Pregnancy, preeclampsia, and the endothelial cellQ43778881
Placental characteristics and reduced risk of maternal breast cancerQ44069259
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsiaQ44434565
Adverse pregnancy outcomes in snuff usersQ44982635
A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasiaQ45271925
Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-CQ46130400
Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptorsQ46258674
Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1.Q46339760
Preeclampsia and subsequent risk of cancer in UtahQ46341131
Regulation of human placental development by oxygen tensionQ46733260
Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsivenessQ46841539
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
Endothelial dysfunction in preeclampsiaQ47879591
Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsiaQ47915288
Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsiaQ47945074
Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity.Q47974115
Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator AwardQ48348609
Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1.Q51037240
Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum.Q51582611
Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia.Q52940276
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
The fetal vascularisation of term human placental villi. II. Intermediate and terminal villi.Q53889480
First trimester insulin resistance and subsequent preeclampsia: a prospective study.Q53974694
Glomerular endothelial cells are maintained by vascular endothelial growth factor in the adult kidney.Q54695121
Urinary Placental Growth Factor and Risk of PreeclampsiaQ56619498
Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with PreeclampsiaQ56619500
Soluble fms-Like Tyrosine Kinase 1 Is Increased in Preeclampsia But Not in Normotensive Pregnancies with Small-for-Gestational-Age Neonates: Relationship to Circulating Placental Growth FactorQ56619503
Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1Q57105968
Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort studyQ57408925
Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces ProteinuriaQ58214894
Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsiaQ58778301
Plasma of Preeclamptic Women Stimulates and Then Inhibits Endothelial ProstacyclinQ59367817
Plasma endothelin levels in preeclampsia: elevation and correlation with uric acid levels and renal impairmentQ68053902
The role of the spiral arteries in the pathogenesis of preeclampsiaQ69446253
Elevated circulating thrombomodulin in severe preeclampsiaQ70465980
Uteroplacental blood flow in pregnancy induced hypertensionQ70962358
[Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values]Q71166954
Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDRQ71530460
Proteases and their inhibitors are indicative in gestational diseaseQ71716172
Preeclampsia -- a state of sympathetic overactivityQ71723202
Abnormal endothelial cell function of resistance arteries from women with preeclampsiaQ72077460
Biochemical corroboration of endothelial involvement in severe preeclampsiaQ72524938
Nitric oxide-mediated vasodilation in human pregnancyQ73281658
Tie-2 and angiopoietin-2 expression at the fetal-maternal interface: a receptor ligand model for vascular remodellingQ73302523
Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsiaQ73399793
Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsiaQ73595868
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
P433issue1
P921main subjectmaternal healthQ6786626
pre-eclampsiaQ61335
P304page(s)1-8
P577publication date2007-05-06
P1433published inMicrovascular ResearchQ15752704
P1476titleMolecular mechanisms of preeclampsia
P478volume75

Reverse relations

cites work (P2860)
Q37257615A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia
Q33418645ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies
Q46491999Abnormal Placentation Associated with Infertility as a Marker of Overall Health
Q33946049Abnormal oxidative stress responses in fibroblasts from preeclampsia infants
Q46277807Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia
Q51785852Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia.
Q38841519Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells
Q28109684An Integrative Analysis of Preeclampsia Based on the Construction of an Extended Composite Network Featuring Protein-Protein Physical Interactions and Transcriptional Relationships
Q54613364Angiogenic factors in maternal circulation and the risk of severe fetal growth restriction.
Q43939628Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction
Q93088427Assessment of the SFlt-1 and sFlt-1/25(OH)D Ratio as a Diagnostic Tool in Gestational Hypertension (GH), Preeclampsia (PE), and Gestational Diabetes Mellitus (GDM)
Q34705582Association between Angiotensinogen M235T Polymorphism and Preeclampsia in Iranian Pregnant Women.
Q28749412Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
Q37153701Association of Gestational Hypertensive Disorders with Retinopathy of prematurity: A Systematic Review and Meta-analysis
Q33762529Autonomic circulatory control during pregnancy in humans
Q37156676Biomarkers for the management of pre-eclampsia in pregnant women.
Q38542456Cardiac Physiology of Pregnancy
Q36428404Cardiovascular mortality after pre-eclampsia in one child mothers: prospective, population based cohort study
Q28081588Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy
Q34670638Circulating angiogenic and antiangiogenic factors in women with eclampsia
Q26801503Combined Screening for Early Detection of Pre-Eclampsia
Q35567911Diagnostic accuracy of the soluble Fms-like tyrosine kinase-1/placental growth factor ratio for preeclampsia: a meta-analysis based on 20 studies
Q37157819Diagnostic and prognostic significance of serum soluble endoglin levels in preeclampsia and eclampsia
Q36120785Difference of concentration of placental soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in severe preeclampsia and normal pregnancy
Q33801203Dysregulation of promyelocytic leukemia (PML) protein expression in preeclamptic placentae.
Q36407107Elevated Soluble Fms-Like Tyrosine Kinase-1 and Placental-Like Growth Factor Levels Are Associated With Development and Mortality Risk in Heart Failure
Q33813477Endothelin-dependent vasoconstriction in human uterine artery: application to preeclampsia
Q35824650Epigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway
Q53203097Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women.
Q92980466Evaluation of Serum Biomarkers and Other Diagnostic Modalities for Early Diagnosis of Preeclampsia
Q35930887Expression Profile of MicroRNAs and mRNAs in Human Placentas From Pregnancies Complicated by Preeclampsia and Preterm Labor
Q36317661Expression and significance of miR155 and vascular endothelial growth factor in placenta of rats with preeclampsia
Q37703260Fetal growth restriction - from observation to intervention
Q37474300Fetal origins of autism spectrum disorders: the non-associated maternal factors
Q34984367Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats
Q82038267Haptoglobin phenotype in women with preeclampsia
Q54360704How placental growth factor detection might improve diagnosis and management of pre-eclampsia.
Q38400715Hypertension in pregnancy: natural history and treatment options
Q40885494Hypertensive disorders of pregnancy and subsequent risk of solid cancer--A nationwide cohort study.
Q37173281Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells
Q37850374Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia
Q34436853Lipid peroxidation is not associated with adipocytokines in preeclamptic women
Q35060531LncRNAs expression in preeclampsia placenta reveals the potential role of LncRNAs contributing to preeclampsia pathogenesis
Q92647905Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia
Q37748773Markers of preeclampsia and the relationship to cardiovascular disease: review of the twenty-first century literature
Q35827036Maternal angiogenic profile in pregnancies that remain normotensive
Q34797328Maternal peripheral blood gene expression in early pregnancy and preeclampsia.
Q36910638Matrix metalloproteinases as drug targets in preeclampsia
Q38120774MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results
Q47643595MoM cutoffs for variables, an important tool for multivariate analysis and accurate interpretation of preeclampsia risk in high-risk pregnancy at 11-13+6 weeks gestation
Q55689625Mutual Balance between Vasohibin-1 and Soluble VEGFR-1 in Endothelial Cells.
Q34075184Myocardial late gadolinium enhancement cardiovascular magnetic resonance in patients with cirrhosis.
Q90751181Nitric oxide and the biology of pregnancy
Q35721088Nitric oxide generation affects pro- and anti-angiogenic growth factor expression in primary human trophoblast
Q26746049No Hypertensive Disorder of Pregnancy; No Preeclampsia-eclampsia; No Gestational Hypertension; No Hellp Syndrome. Vascular Disorder of Pregnancy Speaks for All
Q40561932Novel "omics" approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta
Q37465594Novel approaches for mechanistic understanding and predicting preeclampsia
Q33738656Oxidative injury of the pulmonary circulation in the perinatal period: Short- and long-term consequences for the human cardiopulmonary system
Q50352405Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study
Q34617481Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1
Q26865332Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology
Q33693037Pathophysiology of ischemic placental disease
Q30408297Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth
Q38089817Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: possible relation to preeclampsia and preterm delivery
Q38272641Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia
Q37483999Placental ischemia and breast cancer risk after preeclampsia: tying the knot
Q35860239Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
Q37991228Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature
Q46302568Pre-eclampsia: Molecular events to biomarkers
Q35853166Prediction of Fetal Growth Restriction by Analyzing the Messenger RNAs of Angiogenic Factor in the Plasma of Pregnant Women
Q35051099Preeclampsia and diabetes
Q35798781Preeclampsia in pregnancy and later use of antihypertensive drugs
Q27000388Preeclampsia, hypoxia, thrombosis, and inflammation
Q35153313Pregnancy after kidney transplantation
Q37392711Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature
Q34255236Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women
Q35671379Proteases and sFlt-1 release in the human placenta
Q28080015Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia
Q43568059Quitting smoking during early versus late pregnancy: the risk of preeclampsia and adverse birth outcomes
Q34404445Recent insights into the pathophysiology of preeclampsia
Q35683468Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice
Q52319477Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia.
Q33793455Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy
Q33783531Role of biomarkers in early detection of preeclampsia
Q46823568Serial multimodal monitoring of cerebral manifestations in eclampsia and comparison with normal pregnancy: a clinical study
Q37377138Serum 25(OH) Vitamin D Levels in Polish Women during Pregnancies Complicated by Hypertensive Disorders and Gestational Diabetes.
Q41475835Serum magnesium and calcium in preeclampsia: A comparative study at the Korle-Bu Teaching Hospital, Ghana
Q35071433Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Q50485046Spatial Memory in the Progeny of Rats Subjected to Different Types of Experimental Preeclampsia.
Q40438431Symptoms of Depression Predict Negative Birth Outcomes in African American Women: A Pilot Study
Q91892304Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Q34056273Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity
Q30438979Systems biology of vascular endothelial growth factors
Q35043430The association between hypertensive disorders in pregnancy and bronchopulmonary dysplasia: a systematic review
Q26798193The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia
Q33634903The maternal brain: an organ with peripartal plasticity
Q53443775The outcome of pregnancy with new onset proteinuria without hypertension: retrospective observational study.
Q37041658The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia
Q33668328The therapeutic potential of antioxidants, ER chaperones, NO and H2S donors, and statins for treatment of preeclampsia
Q35107355The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2
Q33389435Thrombotic microangiopathies: multimers, metalloprotease, and beyond
Q51332754Use of serum and urinary soluble sFlt-1 and PLGF in the diagnosis of preeclampsia.
Q38124456Vascular dysfunction in preeclampsia
Q54355512Vascular endothelial growth factor (VEGF) and the VEGF soluble receptor-1 (sFlt-1) in chorionic villus tissue from Chinese women with early recurrent spontaneous abortion.
Q37353319Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression
Q37616832Vascular pool of releasable soluble VEGF receptor-1 (sFLT1) in women with previous preeclampsia and uncomplicated pregnancy
Q34173305Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model

Search more.