Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy

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Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2174/187152910790780096
P8608Fatcat IDrelease_6dnd4hyka5cnpalzr6fn3iepay
P932PMC publication ID2855626
P698PubMed publication ID20041838
P5875ResearchGate publication ID40818831

P2093author name stringRaouf A Khalil
Stephanie J Sheppard
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Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
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Alteration of serum soluble endoglin levels after the onset of preeclampsia is more pronounced in women with early-onset.Q51865183
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Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2Q57670256
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Placental growth factor is a potent vasodilator of rat and human resistance arteries.Q34052025
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Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertensionQ34293890
Angiotensin and cytoskeletal proteins: role in vascular remodelingQ34492824
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Maternal vitamin D deficiency increases the risk of preeclampsiaQ34579840
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsiaQ34656275
Digibind attenuates cytokine TNFalpha-induced endothelial inflammatory response: potential benefit role of digibind in preeclampsiaQ34707051
Hyperglycemia and adverse pregnancy outcomesQ34777029
1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin systemQ34793842
Nutrient involvement in preeclampsiaQ35121229
The genetics of pre-eclampsia: a feto-placental or maternal problem?Q35177399
Enhanced expression of Ang-(1-7) during pregnancyQ35845564
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Angiotensin II and vascular inflammation.Q36140047
Preeclampsia: recent insightsQ36288757
Could antioxidant supplementation prevent pre-eclampsia?Q36325124
Fetal programming of hypertensionQ36341270
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Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsiaQ36618406
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Gestational diabetes, pregnancy hypertension, and late vascular diseaseQ36862954
Diet during pregnancy and risk of preeclampsia or gestational hypertensionQ36867915
The glomerular injury of preeclampsiaQ36883342
Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.Q36948563
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunctionQ37022723
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.Q37072792
Recent progress toward the understanding of the pathophysiology of hypertension during preeclampsiaQ37079628
Endoglin in angiogenesis and vascular diseasesQ37088038
Inflammatory cytokines in the pathophysiology of hypertension during preeclampsiaQ37119326
Altered global gene expression in first trimester placentas of women destined to develop preeclampsiaQ37155561
Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsiaQ37221219
Searching for genetic factors underlying pre-eclampsia: recent progress and persistent challenges.Q37293822
Obesity, gestational diabetes and pregnancy outcomeQ37300560
Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant ratsQ37436219
Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant ratsQ37449704
Human-specific expression of Siglec-6 in the placentaQ38300677
Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathwaysQ38351435
The impact of maternal obesity on maternal and fetal healthQ40007232
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cellsQ40418046
Paradoxical Elevation in Adiponectin Concentrations in Women With PreeclampsiaQ40559156
Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsiaQ41092408
Mechanisms of smooth muscle contractionQ41169589
Resistance artery smooth muscle function in pregnancy and preeclampsiaQ42516324
Nitric oxide synthase activity in placentae from women with pre-eclampsiaQ42520050
Alterations in the renin-angiotensin system in a rat model of human preeclampsiaQ43218182
Stabilization of hypoxia-inducible factor-1{alpha} by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells.Q43413808
Association of maternal endothelial dysfunction with preeclampsiaQ43553727
Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide.Q43576536
Regulation of prostacyclin synthesis by angiotensin II and TNF-alpha in vascular smooth muscleQ43577316
Elevated levels of S-nitrosoalbumin in preeclampsia plasmaQ43633772
High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsiaQ43717221
The role of endothelium-derived hyperpolarizing factor in the regulation of the uterine circulation in pregnant ratsQ43745798
Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsiaQ43872581
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in ratsQ43888051
Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsiaQ44048792
Folic acid supplementation in early second trimester and the risk of preeclampsiaQ44054579
Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant ratsQ44130345
Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressureQ44185600
Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsiaQ44218040
Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndromeQ44401791
Pulmonary vascular endothelial growth factor and nitric oxide interaction during total cardiopulmonary bypass in neonatal pigsQ44456864
Tumor necrosis factor alpha in the bovine oviduct during the estrous cycle: messenger RNA expression and effect on secretion of prostaglandins, endothelin-1, and angiotensin II.Q44475138
Pre-eclampsia (EPH-gestosis)-induced decrease of MMP-s content in the umbilical cord arteryQ44555376
The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort studyQ44632633
Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant ratsQ44715072
Low socioeconomic status is a risk factor for preeclampsia: the Generation R StudyQ44750267
Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsiaQ44897228
The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal bloodQ44929427
Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsiaQ64377002
Pre-eclampsia and trisomy 13Q67592481
Plasma endothelin levels in preeclampsia: elevation and correlation with uric acid levels and renal impairmentQ68053902
Pre-eclampsia and trisomy 13: a possible associationQ69904752
Protein kinase C in uterine and systemic arteries during ovarian cycle and pregnancyQ70116950
Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilationQ71465109
Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibitionQ73087551
Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after deliveryQ73258662
Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsiaQ73399793
Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesisQ73426782
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
Matrix metalloproteinase-2 is elevated in the plasma of women with preeclampsiaQ74226798
Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancyQ74253964
Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant ratsQ74518978
Nitric oxide production with preeclampsiaQ74601245
Circulating levels of immunoreactive cytokines in women with preeclampsiaQ77384781
Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and non-pregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiationQ77519168
Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expressionQ77684136
Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious ratsQ77755765
Differential expression of renal nitric oxide synthase isoforms during pregnancy in ratsQ77945719
Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) dietQ78009520
Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cellsQ78018453
Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancyQ78117582
Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigsQ78396702
Angiotensin-(1-7) in normal and preeclamptic pregnancyQ78568866
Racial disparity in hypertensive disorders of pregnancy in New York State: a 10-year longitudinal population-based studyQ79397360
Evaluation of physiological alterations of the placenta through analysis of cell-free messenger ribonucleic acid concentrations of angiogenic factorsQ80425329
Serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in pre-eclamptic and normal pregnancyQ80454204
Pre-eclampsia: clinical manifestations and molecular mechanismsQ80482285
Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseasesQ80551190
The immunohistochemical evaluation of VEGF in placenta biopsies of pregnancies complicated by preeclampsiaQ80821578
Relationship between increased blood lead and pregnancy hypertension in women without occupational lead exposure in Tehran, IranQ80991877
Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblastQ81086992
Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnanciesQ81236313
Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunctionQ81305565
Tumor necrosis factor-alpha in the placenta is not elevated in pre-eclamptic patients despite its elevation in peripheral bloodQ81432957
Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsiaQ81878607
Calcium supplementation for the prevention of pre-eclampsiaQ82283234
P433issue1
P921main subjecthypertensionQ95566669
P304page(s)33-52
P577publication date2010-03-01
P1433published inCardiovascular & hematological disorders drug targetsQ26867051
P1476titleRisk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy
P478volume10

Reverse relations

cites work (P2860)
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Q33760840eNOS activation and NO function: pregnancy adaptive programming of capacitative entry responses alters nitric oxide (NO) output in vascular endothelium--new insights into eNOS regulation through adaptive cell signaling

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