Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy

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Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy is …
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scholarly articleQ13442814

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P356DOI10.1517/14728222.2015.1067684
P932PMC publication ID4640938
P698PubMed publication ID26294111

P2093author name stringRaouf A Khalil
Sajjadh M J Ali
P2860cites workGeneration of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnanciesQ81236313
Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expressionQ81411178
Tumor necrosis factor-alpha in the placenta is not elevated in pre-eclamptic patients despite its elevation in peripheral bloodQ81432957
Pre-eclampsiaQ81446389
Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsiaQ81813556
First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsiaQ81931104
Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasmaQ83351931
Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in ratsQ84560562
Interleukin 10 gene promoter polymorphisms in women with early-onset pre-eclampsiaQ88149610
STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health StudyQ24339395
VEGF inhibition and renal thrombotic microangiopathyQ24632792
Primary, secondary, and tertiary prevention of pre-eclampsiaQ28176253
Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2Q28221171
Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnanciesQ28222709
Soluble endoglin contributes to the pathogenesis of preeclampsiaQ28244053
Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expressionQ28573546
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
[Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS.Q31732247
STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentasQ33392665
Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancyQ33665037
Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancyQ33793455
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancyQ34051646
Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatmentQ34565651
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsiaQ34656275
Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentasQ34707016
STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardationQ34735623
CD4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancyQ35130793
Subclassification of preeclampsiaQ35196220
Enhanced expression of Ang-(1-7) during pregnancyQ35845564
Abnormal placentation and the syndrome of preeclampsiaQ35941005
Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newbornQ36105461
Preeclampsia: recent insightsQ36288757
The role of the immune system in preeclampsiaQ36791219
The glomerular injury of preeclampsiaQ36883342
Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.Q36948563
Preeclampsia and angiogenic imbalanceQ36971766
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunctionQ37022723
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.Q37072792
Altered global gene expression in first trimester placentas of women destined to develop preeclampsiaQ37155561
Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant ratsQ37200099
Searching for genetic factors underlying pre-eclampsia: recent progress and persistent challenges.Q37293822
Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayersQ37298028
Maternal serum and amniotic fluid inhibin A levels in women who subsequently develop severe preeclampsiaQ37313333
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancyQ37328814
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.Q37447371
Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: effect of tumor necrosis factor-alpha blockadeQ37459545
Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsiaQ37868905
Human-specific expression of Siglec-6 in the placentaQ38300677
Genetic variants in pre-eclampsia: a meta-analysis.Q39489329
Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective studyQ40802999
Intolerance to volume expansion: a theorized mechanism for the development of preeclampsiaQ40847041
Expression of endothelial nitric oxide synthase by extravillous trophoblast cells in the human placentaQ42484206
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant ratsQ42515767
Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide.Q43576536
Neutrophil activation induced by placental factors in normal and pre-eclamptic pregnancies in vitroQ43664278
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in ratsQ43888051
Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressureQ44185600
Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsiaQ44218040
Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndromeQ44401791
The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort studyQ44632633
Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant ratsQ44715072
Paternal and maternal components of the predisposition to preeclampsiaQ45084472
Maternal ethnicity, paternal ethnicity, and parental ethnic discordance: predictors of preeclampsia.Q45961711
GRP78 as a marker of pre-eclampsia: an exploratory study.Q45989281
TNF α G308A gene polymorphism has an impact on renal function, microvascular permeability, organ involvement and severity of preeclampsia.Q46315711
Possible gene-gene interaction of KIR2DL4 with its cognate ligand HLA-G in modulating risk for preeclampsia.Q46333261
Pregnancy outcome and fibrinolytic, endothelial and coagulation markers in women undergoing uterine artery Doppler screening at 23 weeksQ46334260
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretionQ46344658
Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsiaQ46440312
Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia conditionQ46454719
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteinsQ46789404
Uterine vascular function in a transgenic preeclampsia rat modelQ46808246
Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisitesQ46886600
Angiotensinogen genotype and plasma volume in nulligravid womenQ47703792
Association of -634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm deliveryQ47836743
Vascular contraction and preeclampsia: downregulation of the Angiotensin receptor 1 by hemopexin in vitroQ47884975
Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsiaQ47915288
Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat.Q50514586
Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha.Q51359651
Evaluation of metalloproteinases 2 and 9 and their inhibitors in physiologic and pre-eclamptic pregnancy.Q51767630
Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors.Q53538854
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
Systemic hemodynamics and regional blood flow during chronic nitric oxide synthesis inhibition in pregnant rats.Q54148277
Cellular mRNA expressions of anti-oxidant factors in the blood of preeclamptic women.Q54485033
Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?Q54551217
Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats.Q54661322
Soluble fms-like Tyrosine Kinase 1Q56619509
Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2Q57670256
Polymorphisms of FAS and FAS ligand genes in preeclamptic womenQ61851339
Plasma level of soluble c-Met is tightly associated with the clinical risk of preeclampsiaQ61964340
Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesisQ73426782
Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant ratsQ74518978
Nitric oxide production with preeclampsiaQ74601245
Is preeclampsia an infectious disease?Q77153770
Circulating levels of immunoreactive cytokines in women with preeclampsiaQ77384781
Activation of leukocytes during the uteroplacental passage in preeclampsiaQ77513220
Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expressionQ77684136
Microalbuminuria after pregnancy complicated by pre-eclampsiaQ77799245
Trial of prophylactic administration of TXA2 synthetase inhibitor, ozagrel hydrochloride, for preeclampsiaQ78220660
Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxinQ79278420
Renal angiotensin-II receptors expression changes in a model of preeclampsiaQ80238082
Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertensionQ80361560
Serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in pre-eclamptic and normal pregnancyQ80454204
Circulating angiogenic factors in singleton vs multiple-gestation pregnanciesQ80564650
Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsiaQ80812036
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmaternal healthQ6786626
P304page(s)1495-1515
P577publication date2015-08-21
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleGenetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy
P478volume19

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cites work (P2860)
Q48133399Antihypertensive methyldopa, labetalol, hydralazine, and clonidine reversed tumour necrosis factor-α inhibited endothelial nitric oxide synthase expression in endothelial-trophoblast cellular networks.
Q92528205Association of circulating saturated fatty acids with the risk of pregnancy-induced hypertension: a nested case-control study
Q51000408Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy.
Q38670775Differential responses of mesenteric arterial bed to vasoactive substances in L-NAME-induced preeclampsia: Role of oxidative stress and endothelial dysfunction
Q38720237Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α.
Q46342648Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia
Q47223491Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease
Q37136212Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia
Q95840724Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function
Q58589187Molecular Determinants of Microvascular Dysfunction in Hypertensive Pregnancy and Preeclampsia
Q88609514Neonatal outcomes of extremely preterm infants exposed to maternal hypertension and cigarette smoking
Q54119733Placental Growth Factor Reverses Decreased Vascular and Uteroplacental MMP-2 and -9 and increased MMP-1 and -7 and Collagen I and IV in Hypertensive Pregnancy.
Q57815317Response Gene to Complement 32 Maintains Blood Pressure Homeostasis by Regulating α-Adrenergic Receptor Expression

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