Obesity and high fat diet induce distinct changes in placental gene expression and pregnancy outcome.

scientific article published on 9 February 2018

Obesity and high fat diet induce distinct changes in placental gene expression and pregnancy outcome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/EN.2017-03053
P932PMC publication ID6456933
P698PubMed publication ID29438518

P50authorDavid García-GalianoQ51322774
P2093author name stringSusan J Allen
Carol F Elias
Mark J Hoenerhoff
Xingfa Han
Beatriz C Borges
Erica B Mahany
Sanseray da Silveira Cruz-Machado
Nicole H Bellefontaine
P2860cites workHuman cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?Q24561702
Insights into obesity and diabetes at the intersection of mouse and human geneticsQ26852866
Inflammation and metabolic disordersQ27860923
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptinQ28115346
A frameshift mutation in MC4R associated with dominantly inherited human obesityQ28117916
A frameshift mutation in human MC4R is associated with a dominant form of obesityQ28285286
Targeted disruption of the melanocortin-4 receptor results in obesity in miceQ28302831
Prevalence and trends in obesity among US adults, 1999-2008Q29547759
Obesity as a medical problemQ29616305
Placental development: lessons from mouse mutantsQ29618167
Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal stateQ30352449
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.Q30433558
Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002.Q30819235
Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic womenQ31889884
Topological properties and spatial organization of villous capillaries in normal and diabetic placentas.Q32148794
Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.Q33779029
Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletonsQ33795191
Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.Q33888360
Maternal body mass index and congenital anomaly risk: a cohort study.Q34021962
Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and miceQ34359200
Association between outcome of pregnancy and glycaemic control in early pregnancy in type 1 diabetes: population based studyQ34360780
Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentationQ34506096
Leptin signaling in Kiss1 neurons arises after pubertal developmentQ34626000
Leptin mediates the increase in blood pressure associated with obesityQ34655110
Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placentaQ34824188
Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutritionQ35001389
Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysisQ35500790
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in miceQ35780266
Sexual differences in the control of energy homeostasisQ35896671
Leptin in pregnancy: an updateQ36305240
Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanismsQ36422496
The known and unknown of leptin in pregnancyQ36491152
Activation of NF-κB in placentas of women with preeclampsiaQ36525564
Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controlsQ36672096
Animal models of human placentation--a reviewQ36695431
Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth.Q36699655
Obesity in women: a life cycle of medical riskQ36984914
Diet before and during Pregnancy and Offspring Health: The Importance of Animal Models and What Can Be Learned from ThemQ37044817
High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 miceQ37061691
Obese melanocortin-4 receptor-deficient rats exhibit augmented angiogenic balance and vasorelaxation during pregnancyQ37244977
Leptin targets in the mouse brainQ37260766
Placental vascularity and markers of angiogenesis in relation to prenatal growth status in overnourished adolescent ewesQ37337005
Adiponectin in insulin resistance: lessons from translational researchQ37474736
Obesity in pregnancy: prevalence and metabolic consequencesQ37629198
Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis.Q37670103
Maternal obesity is associated with a lipotoxic placental environmentQ37689149
Obesity and the risk and detection of fetal malformationsQ37734754
Toll-like receptors: linking inflammation to metabolismQ37796144
Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth.Q37804549
Maternal obesity and stillbirthQ37959652
Role of leptin in pregnancy: consequences of maternal obesityQ38075214
Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysisQ38204943
Unresolved controversies in gestational diabetes: implications on maternal and infant healthQ38220866
Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance stateQ38330911
Endocrine and metabolic adaptations to pregnancy; impact of obesityQ38650329
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.Q38700457
Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortionQ38795516
Dual-cutoff of sFlt-1/PlGF ratio in the stratification of preeclampsia: a systematic review and meta-analysisQ39185536
Significance of platelet endothelial cell adhesion molecule-1 (PECAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions in preeclamptic placentaeQ39643991
Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cellsQ39820857
Corrigendum: Gene expression profiling of pre-eclamptic placentae by RNA sequencingQ43101948
Maternal obesity and risk of preterm deliveryQ44316782
Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments.Q44357240
Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?Q44668801
An allelic series for the leptin receptor gene generated by CRE and FLP recombinaseQ45076042
HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia: a longitudinal prospective study in high risk populationQ46314287
Pre-pregnancy weight and the risk of stillbirth and neonatal deathQ46344748
Regulation of human placental development by oxygen tensionQ46733260
Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity.Q47801247
Nuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case-cQ47885023
AMPKα2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female MiceQ47983321
Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF levelQ48117226
Body composition during normal pregnancy: reference ranges.Q52008007
Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.Q52186881
Adipose tissue as an endocrine organQ57257904
Fibroblast growth factor-2 and fibroblast growth factor receptor-1 mRNA expression and peptide localization in placentae from normal and diabetic pregnanciesQ74456008
Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentrationQ74603140
Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsiaQ79763571
Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesityQ84538745
Relationship between TLR4 and CCL2 expression and recurrent spontaneous abortionQ87357436
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpregnancy outcomeQ66057507
P304page(s)1718-1733
P577publication date2018-04-01
P1433published inEndocrinologyQ3054009
P1476titleObesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome
P478volume159

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cites work (P2860)
Q92921158Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis
Q61801051The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease
Q50422282The War on the Placenta: The Differing Battles of High-Fat Diet and Obesity.

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