Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

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Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans is …
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scholarly articleQ13442814

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P819ADS bibcode2010PNAS..107.3770S
P356DOI10.1073/PNAS.0915162107
P932PMC publication ID2840514
P698PubMed publication ID20133713
P5875ResearchGate publication ID41408565

P50authorRino RappuoliQ2154243
Mariagrazia PizzaQ100420770
Alessia BiolchiQ101409696
Marzia Monica GiulianiQ104482851
Laura SantiniQ104482853
Maria ScarselliQ114320978
Silvana SavinoQ114320980
Beatrice AricòQ114321062
Laura CiucchiQ114738870
Davide SerrutoQ114738872
Tiziana SpadafinaQ114738878
Marta TontiniQ114738879
Francesco BertiQ117835530
Kate L SeibQ42328606
Paolo CostantinoQ44846314
P2093author name stringAndrew G Plaut
J Simon Kroll
Jiazhou Qiu
Richard Moxon
Sanjay Ram
Lisa A Lewis
John J Donnelly
Clíona O'Dwyer
P2860cites workHuman milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzaeQ22003949
Identification of a heparin-binding hemagglutinin present in mycobacteriaQ28486374
Heparin and heparan sulfate: structure and functionQ31097715
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.Q33892877
Localization of the heparin-binding site on complement factor HQ67902469
Identification of multiple sites of interaction between heparin and the complement systemQ70699961
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal diseaseQ71538870
Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigensQ81560667
Prevalence and sequence variations of the genes encoding the five antigens included in the novel 5CVMB vaccine covering group B meningococcal diseaseQ83222896
Functional significance of factor H binding to Neisseria meningitidisQ83918204
Interlaboratory standardization of the measurement of serum bactericidal activity by using human complement against meningococcal serogroup b, strain 44/76-SL, before and after vaccination with the Norwegian MenBvac outer membrane vesicle vaccineQ33910760
Sulfated polysaccharide-directed recruitment of mammalian host proteins: a novel strategy in microbial pathogenesisQ34001696
Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonanceQ34068498
Autotransported serine protease A of Neisseria meningitidis: an immunogenic, surface-exposed outer membrane, and secreted protein.Q34127907
Enhanced bacterial virulence through exploitation of host glycosaminoglycansQ34611457
Epidemic meningitis, meningococcaemia, and Neisseria meningitidisQ34644525
Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sitesQ34648253
Heparin protects Opa+ Neisseria gonorrhoeae from the bactericidal action of normal human serumQ35409397
Microbial adherence to and invasion through proteoglycansQ35533138
Progress towards the development of new vaccines against whooping coughQ35624976
A universal vaccine for serogroup B meningococcusQ36101910
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistanceQ36470692
Vaccine-induced opsonophagocytic immunity to Neisseria meningitidis group B.Q36672529
Conquering the meningococcusQ36711456
Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine developmentQ37531325
Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processesQ37671601
Sulfated glycoconjugate receptors for the Bordetella pertussis adhesin filamentous hemagglutinin (FHA) and mapping of the heparin-binding domain on FHA.Q38302979
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcusQ39981028
Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulatorQ40387262
Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptorsQ41046627
Characterization of fHbp, nhba (gna2132), nadA, porA, sequence type (ST), and genomic presence of IS1301 in group B meningococcal ST269 clonal complex isolates from England and WalesQ41845489
Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activityQ42173007
Many carried meningococci lack the genes required for capsule synthesis and transportQ43450474
Analysis of transcriptional control mechanisms of capsule expression in Neisseria meningitidisQ43811753
A Neisserial autotransporter NalP modulating the processing of other autotransportersQ44655589
Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activityQ46121635
Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005.Q53252856
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectNeisseria meningitidisQ154625
P304page(s)3770-3775
P577publication date2010-02-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleNeisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans
P478volume107

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